<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20416

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHATNCTSAVNNSAVGGSLGRDSSRAESSALSSNFPVNSRRSSQLASYKLRCEKEPLNSRLPPPDFHPPTANCPEETLTKDYVLAGYRETVEGLEESREISLSQIQTFSKPVILKCKEAIRKYHRAINESRAQKRKAGQVYGVPLTGNLLSKPGVYPEQKASSEDFRKKWIEGLSQQHKRLRSLADHVPHGYRRKSLFEVLIRNNVPLLRATWYIKVTYLNQVRPGSSSTSSGSPDKTRLSRSDQWTKDVIEYLQYLLDEFVSKNNSQSTMHTKDRSPQFAYTGSIQHKSDSVLALVDGEEPSLHFKWWYVVRIIQWHYAEGLLLPSLIIDWVLTQLQEKESLGILQLLLPIIYGVIETIVLSQSYVRTLVGIAIRFIQEPSPGGSDLVDNSRREYTISALVEILRYLILAVPDTFVALNCFPLPSRVVSNATNDGSLITRATIEGGNKGLEGQGHSMSIDSVVTSIQKCAVNLSRAARPGQSGHNVAKAVHELDKSLTHGDITIAYKCMFEDFCDEAADKRWITEVSTYLRSSLKWVGTVSSSFMCSVFFVCEWATCDFRDFRTTPPHGVKFSGKRDFSQIYVATRLLEMKMRNMRSSRKSGRNVNEVENKSKVGIRKVKDLSHFFQSPGPLHDIIVCWLDQHQTQNGEGFKRVQLLINELIRSGIFYPQAYVRELIVSGIMGRNGSMADFDRRRRHYKLLKHLSGSYIHKALEEAQIAEAPLISEAMHIYSNERRLLLHELLDHTKNTNLSQKQKNYHKSGKDGSWKLPSSPASDSVSSKNINRTSKNEELMNSIATLLHFPNSLSTPVGNGLDESQGIKKPTGPMAIRSDLGEGTPGCEECRRAKRQKVEERSPYQSSNLSDDEDVWWVKKGHKSLDSFRVDPPVKPVKQATRGRQKMVRKTSSLAQLAAARIEGSQGASTSHVCDSRVNCPHHRNGNDNDVLKTADPIRTAHSVDISSIGKVLKRLPLDEKRVVVVWLMGIVRQLVDEAGKVSETAAKAGQYGRNLPPVDDKGLAKWKLGEDELSTILYVMDVCDDLVSAVRFLVWLLPKVPINPVPTVHGGRNVMIVPRNVENQLFAVGEAYILSSLRRYENILAAADLIPETLSAMMQRASVVMASNGRVSGSVALVFARQMLKKYGHVASVVEWIKNFKTTSDKRLVMELESGRSSDGEFGFPLGVPAGVQDFDEYLRQKINGVRFSRVGINMRDTVQRLVDEAIPSFYGQDKKSFSGGPLKRHSTEKSDDGHSIAQQVVKGLLDCMRQTGGAAQEGDPTLVAFAVSAIVNNVGLVIGKIPDITPLSLNFARHILRIHLTCLSLLKDALGERQSRVFEIALATEASSALAQVFSPPKASRGQLQLSPETRDSMSNENLNSTGKTFSKAAKTTGAISALVVGAVLQGIATLERMVTVFRLKEGLNVIQFVRGTRSSSNGNVRTIGDLKMDSLVEVSVHWFRVLVGNCRSVSDGFIVELLGESSVVALSRIQRMLPINLVVPPAFAIFGFLVWRRFVLSASVMARDNISQLFQSLTLAINDAIKHLPFRDVCLRETAALYDIVAADPSDSEFASMLDLSGPDMHSKIAAFVPLRARIFLNSIIDCHLPTEILVHDDGNRGSGHTEIKSLHAENETKLLDKLVLILDTLQPAKFHWQWVELRLLLNEQALLEKVEARDASLVEALSSFSPNNDNVGTKENENNFIQMVLTRLLVRPDAAPLFSEVVHLLGRSLEDEVLLQAKWFLKGHDVLFGRKSIRQRLTNIAENKGLSFKTQFSKPWGWCNSAPELPPKRGNKKRKFESGSLEEGEVVDDGTDSKRHGRTFSQVSDIEALIVSQQHVTEKALVELLLPCIDQSSDDSRVTFASDLIKLMNEIEQQISTVTHGVTKQAGTVASGIEGPVSKVNTRKGIRGGSPGLARRPAAPVEMMLPSPSALRASMSLRLQLLLRLLPVICVDGEPSARNMRHMLASVVLRLLGSRVVHEDADLSNPSSRFSVKREAGSTIESSSAVDLGESLFDRLLLVLHALLSSSQPYWLRPKSLSKSTPESTRDSTLYDREVAESLQNELDGMQLPDTVRWRIQTAMPFVFPSVKLSISCEPPNVPLSALGFLQPSISIPGPHPVSLRNNQVSSSRSISNGPSKATKPLSSQPDSDIEIDPWTVLEDGAGSGPSSLNAAAIAGSDHANMKASSWLKGAVRVRRMDLTYIGAIDDDS
Length2210
PositionKinase
OrganismArtemisia annua (Sweet wormwood)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae> Artemisiinae> Artemisia.
Aromaticity0.06
Grand average of hydropathy-0.264
Instability index48.18
Isoelectric point9.07
Molecular weight244681.61
Publications
PubMed=29703587

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20416
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     351.35|      88|     352|      91|     178|       1
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   91-  178 (144.13/115.26)	RET.VE....GLE.ESREISLSQIQTFSKPVILKCK..EAIRKYHRAINESRAQKRKAGQVYGVPLT.GNL.LSKPG.........VYPEQKASSEDFRKKWIEGLS
  444-  531 (107.57/83.48)	RAT.IEggnkGLEgQGHSMSIDSVVT....SIQKCA..VNLSRAARP.GQSGHNVAKAVHELDKSLThGDItIAYKC.........MFEDFCDEAAD..KRWITEVS
  567-  657 (99.64/76.58)	RTTpPH....GVK.FSGKRDFSQIYVATRLLEMKMRnmRSSRKSGRNVNEVE.NKSKVG.IRKVKDL.SHF.FQSPGplhdiivcwLDQHQTQNGEGFKR.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     346.69|     109|     354|    1659|    1768|       2
---------------------------------------------------------------------------
 1659- 1768 (171.86/127.86)	RLLLNEQALLEKVEA...RDASLVEALSSfSPNNDNVGTKE......NENNFIQMVLTRLLVRPDAAPLFSEVVHLLGRSLEDEVLLQAKWFLKGHDVLFGRKSIRQRLTNIAENKGLS
 2016- 2133 (174.83/124.94)	RLLLVLHALLSSSQPywlRPKSLSKSTPE.STRDSTLYDREvaeslqNELDGMQLPDTVRWRIQTAMPFVFPSVKLSISCEPPNVPLSALGFLQPSISIPGPHPVSLRNNQVSSSRSIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.28|      38|     354|     815|     921|       3
---------------------------------------------------------------------------
  823-  863 (61.63/76.20)	GIKKPTGPMAIRSDLGEGTPGCeeCRRAKrQKVEERSPYQS
 1893- 1930 (68.66/14.81)	GIEGPVSKVNTRKGIRGGSPGL..ARRPA.APVEMMLPSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     219.24|      76|     413|    1086|    1184|      10
---------------------------------------------------------------------------
 1096- 1184 (101.26/138.56)	RRYenILAAADLIPETLSAMMQraSVVMASNGRVSgsvALVFARQMLKKYGHVASVVEwiknfKTTSDKRLVMELE.SG...RSSDGEFgFPL
 1512- 1591 (117.98/86.30)	RRF..VLSASVMARDNISQLFQ..SLTLAINDAIK...HLPFRDVCLRETAALYDIVA.....ADPSDSEFASMLDlSGpdmHSKIAAF.VPL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20416 with Med12 domain of Kingdom Viridiplantae
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