<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20415

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMQRYHATNCTSAVNNSAVGGSLGRDSSRAESSALSSNFPVNSRRSSQLASYKLRCEKEPLNSRLPPPDFHPPTANCPEETLTKDYVLAGYRETVEGLEESREISLSQIQTFSKPVILKCKEAIRKYHRAINESRAQKRKAGQVYGVPLTGNLLSKPGVYPEQKASSEDFRKKWIEGLSQQHKRLRSLADHVPHGYRRKSLFEVLIRNNVPLLRATWYIKVTYLNQVRPGSSSTSSGSPDKTRLSRSDQWTKDVIEYLQYLLDEFVSKNNSQSTMHTKDRSPQFAYTGSIQHKSDSVLALVDGEEPSLHFKWWYVVRIIQWHYAEGLLLPSLIIDWVLTQLQEKESLGILQLLLPIIYGVIETIVLSQSYVRTLVGIAIRFIQEPSPGGSDLVDNSRREYTISALVEILRYLILAVPDTFVALNCFPLPSRVVSNATNDGSLITRATIEGGNKGLEGQGHSMSIDSVVTSIQKCAVNLSRAARPGQSGHNVAKAVHELDKSLTHGDITIAYKCMFEDFCDEAADKRWITEVSTYLRSSLKWVGTVSSSFMCSVFFVCEWATCDFRDFRTTPPHGVKFSGKRDFSQIYVATRLLEMKMRNMRSSRKSGRNVNEVENKSKVGIRKVKDLSHFFQSPGPLHDIIVCWLDQHQTQNGEGFKRVQLLINELIRSGIFYPQAYVRELIVSGIMGRNGSMADFDRRRRHYKLLKHLSGSYIHKALEEAQIAEAPLISEAMHIYSNERRLLLHELLDHTKNTNLSQKQKNYHKSGKDGSWKLPSSPASDSVSSKNINRTSKNEELMNSIATLLHFPNSLSTPVGNGLDESQGIKKPTGPMAIRSDLGEGTPGCEECRRAKRQKVEERSPYQSSNLSDDEDVWWVKKGHKSLDSFRVDPPVKPVKQATRGRQKMVRKTSSLAQLAAARIEGSQGASTSHVCDSRVNCPHHRNGNDNDVLKTADPIRTAHSVDISSIGKVLKRLPLDEKRVVVVWLMGIVRQLVDEAGKVSETAAKAGQYGRNLPPVDDKGLAKWKLGEDELSTILYVMDVCDDLVSAVRFLVWLLPKVPINPVPTVHGGRNVMIVPRNVENQLFAVGEAYILSSLRRYENILAAADLIPETLSAMMQRASVVMASNGRVSGSVALVFARQMLKKYGHVASVVEWIKNFKTTSDKRLVMELESGRSSDGEFGFPLGVPAGVQDFDEYLRQKINGVRFSRVGINMRDTVQRLVDEAIPSFYGQDKKSFSGGPLKRHSTEKSDDGHSIAQQVVKGLLDCMRQTGGAAQEGDPTLVAFAVSAIVNNVGLVIGKIPDITPLSLNFARHILRIHLTCLSLLKDALGERQSRVFEIALATEASSALAQVFSPPKASRGQLQLSPETRDSMSNENLNSTGKTFSKAAKTTGAISALVVGAVLQGIATLERMVTVFRLKEGLNVIQFVRGTRSSSNGNVRTIGDLKMDSLVEVSVHWFRVLVGNCRSVSDGFIVELLGESSVVALSRIQRMLPINLVVPPAFAIFGFLVWRRFVLSASVMARDNISQLFQSLTLAINDAIKHLPFRDVCLRETAALYDIVAADPSDSEFASMLDLSGPDMHSKIAAFVPLRARIFLNSIIDCHLPTEILVHDDGNRGSGHTEIKSLHAENETKLLDKLVLILDTLQPAKFHWQWVELRLLLNEQALLEKVEARDASLVEALSSFSPNNDNVGTKENENNFIQMVLTRLLVRPDAAPLFSEVVHLLGRSLEDEVLLQAKWFLKGHDVLFGRKSIRQRLTNIAENKGLSFKTQFSKPWGWCNSAPELPPKRGNKKRKFESGSLEEGEVVDDGTDSKRHGRTFSQVSDIEALIVSQQHVTEKALVELLLPCIDQSSDDSRVTFASDLIKLMNEIEQQISTVTHGVTKQAGTVASGIEGPVSKVNTRKGIRGGSPGLARRPAAPVEMMLPSPSALRASMSLRLQLLLRLLPVICVDGEPSARNMRHMLASVVLRLLGSRVVHEDADLSNPSSRFSVKREAGSTIESSSAVDLGESLFDRLLLVLHALLSSSQPYWLRPKSLSKSTPESTRDSTLYDREVAESLQV
Length2062
PositionKinase
OrganismArtemisia annua (Sweet wormwood)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae> Artemisiinae> Artemisia.
Aromaticity0.06
Grand average of hydropathy-0.263
Instability index47.66
Isoelectric point9.15
Molecular weight228989.14
Publications
PubMed=29703587

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20415
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     397.40|     137|     365|      19|     186|       1
---------------------------------------------------------------------------
   19-  186 (192.32/188.76)	GGSLGRDSSRAES..SALssnfpVNSRRSSQLA...SY.KLRCekEPLNSRLpppdfhPPTANCPEETLTkdyvlagyRETVEG....LE.ESREISLSQIQTfskpVILKCKEAIRKYHRAiNESRAQKRKAGQVYGVPLT.GNL.LSKPGVYPEQKASSEDfrKKWIEGLSQQhkrLRS
  387-  536 (205.08/126.27)	GGSDLVDNSRREYtiSAL.....VEILRYLILAvpdTFvALNC..FPLPSRV......VSNATNDGSLIT........RATIEGgnkgLEgQGHSMSIDSVVT....SIQKCAVNLSRAARP.GQSGHNVAKAVHELDKSLThGDItIAYKCMFEDFCDEAAD..KRWITEVSTY...LRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.28|      38|     483|     257|     296|       2
---------------------------------------------------------------------------
  257-  296 (62.20/45.18)	LQYLLDEFVSKNNS..QSTMHTKDRSPQFAYTGSiqHKSDSV
  743-  782 (63.08/39.63)	LHELLDHTKNTNLSqkQKNYHKSGKDGSWKLPSS..PASDSV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.11|      24|     483|    1301|    1337|       6
---------------------------------------------------------------------------
 1310- 1334 (37.78/41.76)	FARHILRIHLTCLSLLKDAlGERQS
 1596- 1619 (44.33/15.85)	FLNSIIDCHLPTEILVHDD.GNRGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.33|      26|     367|     785|     820|       7
---------------------------------------------------------------------------
  795-  820 (45.13/17.94)	ELMNSIATLLHFPNSLSTPVG.NGLDE
 1169- 1195 (42.20/20.41)	ELESGRSSDGEFGFPLGVPAGvQDFDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.65|      16|     413|    1291|    1306|      18
---------------------------------------------------------------------------
 1291- 1306 (29.08/22.55)	NN.VGLVIGKI...PDITPL
 1699- 1718 (19.57/12.02)	NNfIQMVLTRLlvrPDAAPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20415 with Med12 domain of Kingdom Viridiplantae
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