<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20414

Description Mediator of RNA polymerase II transcription subunit 19a
SequenceMDPESKKFGKGPRELTGAVDLISYYKLLPHHEFFCKKSLPLSISDTHYLHNVVGESEIRKGEGMQLDQLIQNTSFPRDTNTRILPFDMGILGEAFQLRETAPVDLPSSEKGTPTVAGKSKSESKDKEKKHRKHKDKDREKDREHKKHKHRHKDRSKDKDKEKKRDKSSNLDSGAESSKKHHEKKRKHDGDEDLNDIHRHKKSKHKSSKMDEMGAMKLTA
Length219
PositionHead
OrganismArtemisia annua (Sweet wormwood)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae> Artemisiinae> Artemisia.
Aromaticity0.04
Grand average of hydropathy-1.460
Instability index38.09
Isoelectric point9.56
Molecular weight25278.26
Publications
PubMed=29703587

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20414
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.37|      15|      15|     132|     146|       1
---------------------------------------------------------------------------
  132-  146 (28.44/11.79)	KHKDKDREKDREHKK
  148-  162 (25.93/10.11)	KHRHKDRSKDKDKEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.29|      21|      32|      61|      81|       2
---------------------------------------------------------------------------
   61-   81 (37.77/26.37)	GEGMQLDQL..IQNTSFPRDTNT
   92-  114 (31.51/20.97)	GEAFQLRETapVDLPSSEKGTPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.65|      11|      37|     164|     174|       5
---------------------------------------------------------------------------
  164-  174 (19.12/ 9.21)	RDKSSNLDSGA
  187-  197 (16.54/ 7.05)	HDGDEDLNDIH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20414 with Med19 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LRETAPVDLPSSEKGTPTVAGKSKSESKDKEKKHRKHKDKDREKDREHKKHKHRHKDRSKDKDKEKKRDKSSNLDSGAESSKKHHEKKRKHDGDEDLNDIHRHKKSKHKSSKMDEMGAMKLTA
2) VVGESEIRKGEGMQLDQLIQNTSFPRDTNTRI
97
52
219
83










Molecular Recognition Features






MoRF SequenceStartStop




1) KDKEKKHRKHKDKDREKDREHKKHKHRHKDRSKDKDKEKKRDKSSNLDSGAESSKKHHEKKRKHDGDEDLNDIHRHKKSKHKSSKMDEMGAMKLTA
124
219