<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20401

Description Cyclin-dependent kinase E-1
SequenceMSNRSSGGNNRPEWLQQYDLIGKIGEGTYGLVFLAKIKSNRTKSIAIKKFKQSKDGDGVSPTAIREIMLLREINHENVVKLVNVHINHIDMSLYLAFDYAEHDLYEIIRHHRDKVNQAINQYTVKSILWQLLNGLNYLHSNWIMHRDLKPSNILVMGDGEEQGVVKIADFGLARIYQAPLKPLSDNGVVVTIWYRAPELLLGGKHYTSAVDMWAVGCIFAELLTLKPLFQGQEVKATPNPFQLDQLDKIFKVLGHPTVDKWPTLANLPHWQSDQQHIQGHKYDSPGLYSVVHLSPKNPAYDLLSKMLEYDPRKRITAAQALDHEYFRMEPLPGRNALVPPQPGEKIVNYPTRPVDTNTDFEGTASLQPAPQASGNQVAGGMGGPHVMGNRNIPRPMHMAGVQRMQQQNMAAYNLASQAGMGGTMNNPGNIPMQRGVAAQPHQQQQQQQQLRRKDGMGMPGYPQQKSRRF
Length469
PositionKinase
OrganismArtemisia annua (Sweet wormwood)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> campanulids> Asterales> Asteraceae> Asteroideae> Anthemideae> Artemisiinae> Artemisia.
Aromaticity0.08
Grand average of hydropathy-0.522
Instability index46.59
Isoelectric point9.35
Molecular weight52764.77
Publications
PubMed=29703587

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein serine/threonine kinase activity	GO:0004674	IEA:UniProtKB-KW

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20401
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.69|      36|      37|     372|     407|       1
---------------------------------------------------------------------------
  335-  369 (35.34/15.70)	...NALV.PPQPGEKIV....NYP.tRPVDtntdFEGTASLQPA
  372-  407 (69.37/37.37)	ASGNQVA.GGMGGPHVMGNR.NIP..RPMH....MAGVQRMQQQ
  410-  447 (48.97/24.38)	AAYNLASqAGMGGT..MNNPgNIPmqRGVA....AQPHQQQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     389.42|     122|     130|      14|     141|       2
---------------------------------------------------------------------------
   14-  141 (193.12/148.72)	WLQQYDL....IGKIGEG.TYGLVFLAKIKSNRTKSIAIKKFkqSKDGDGVSPTAIREIMLLREINHENVVKLVNVHINHID.MSLYLAFD....YAEHDLYEIirHHRDKVNQAINQYTVKSilWQLLNGLNYLHSN
  142-  273 (196.30/133.46)	WIMHRDLkpsnILVMGDGeEQGVVKIADFGLARIYQAPLKPL..SDNGVVVTIWYRAPELLLGGKHYTSAVDMWAVGCIFAElLTLKPLFQgqevKATPNPFQL..DQLDKIFKVLGHPTVDK..WPTLANLPHWQSD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20401 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) EPLPGRNALVPPQPGEKIVNYPTRPVDTNTDFEGTASLQPAPQASGNQVAGGMGGPHVMGNRNIPRPMHMAGVQRMQQQNMAAYNLASQAGMGGTMNNPGNIPMQRGVAAQPHQQQQQQQQLRRKDGMGMPGYPQQKSRRF
329
469










Molecular Recognition Features






MoRF SequenceStartStop




1) KSIAIKKFK
2) QQQLRRKDGMGMPGYPQQKSRRF
43
447
51
469