<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20351

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMVELGREINLIDEVSGCPFEVVYEVCVFDLDRPWEEFRVTTVSVPVAYMRWDPSGSHLLIVDAGGTFTVWIMKDYLINTWEEYGSTALPGEEVLILAWLHNGIQVLFNPEKHDQVAYNDKFQRSKFNPTVTHFGNKPLDGWMAVTATGLVTVGLLQEPGQKLIMGKQCLAPGYLRLTQADIAFMASGEVMVAASDGTVGSAIQCFIISVKLENNACKITTHPGASFFLKSTAEYSNRDLHLHVSKICFLNRENSDILLVCCAGPNHSSVEVWHLLEQTMPLNRIFQSVANPELACKTPKWMHKASIVHNAHLTDIARPKLPMNRTYNIETTAFVAYFACTYRDGVIKIIHRQSYQVIHTSSMETLGGPVSSVPGDHLLTSSPHLMSCVQTSTGCGLVGQSQGSLCVFRVFNSRDGCLQLLPGFLVLLLEYTMFVGHDIWDVLLAVRQGMVEGLAQQIIDNFQKQTPSFQELIRMRLLRLRMALCSIVPSGRQRAAECRALLTLFSISTVLRSIFRPKAVSVQEKTPAEKLTAHCSISTETDIDALIKNLDPEEFIVESVKKEKGSQASLQMLQPFIQWVADFVLHLLSSVPLIQNGHNMPGMGLLRDVSVLVMLRDLLAIMRLWGSINPACLPTFSTTSFHDCLGHIFKLLTRVWQIRKEGASMELEEGLVDECASLPSKVLIPDFHFSYGRDSCSFAVFTQPPPLRFSFGKEPDYLYAIRKTFHVYPAETAPDTKQCHDIVRHIHLGITPCEPVRECIRCGAFSLLRTMARSTLLESWEKRFIRNCVCGARWKLSNSDFKHVAKKRTK
Length809
PositionTail
OrganismPomacea canaliculata (Golden apple snail)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Mollusca> Gastropoda> Caenogastropoda> Architaenioglossa> Ampullarioidea> Ampullariidae> Pomacea.
Aromaticity0.09
Grand average of hydropathy0.045
Instability index42.95
Isoelectric point7.31
Molecular weight90715.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20351
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.30|      23|      40|     142|     164|       1
---------------------------------------------------------------------------
  142-  164 (38.72/26.91)	MAVTATGLVTV....GLLQEPGQKLIM
  181-  207 (34.58/23.25)	IAFMASGEVMVaasdGTVGSAIQCFII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     233.53|      71|     199|     273|     347|       2
---------------------------------------------------------------------------
  273-  347 (120.59/92.23)	HLLEQTMPLNRIFQSVANPELACKTPKWMHKASIVhnahLTDIARPKL..PMNRTYNIETTAFVAYFACTYRDGVIK
  475-  547 (112.94/76.18)	RLLRLRMALCSIVPSGRQRAAECRALLTLFSISTV....LRSIFRPKAvsVQEKTPAEKLTAHCSISTETDIDALIK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     147.85|      42|      97|     616|     659|       5
---------------------------------------------------------------------------
  616-  659 (73.27/48.34)	DLLAIMRLWGSINPA.CLPtfSTTSFHDCLGHIFKLLTRVWQIRK
  715-  757 (74.57/43.25)	DYLYAIRKTFHVYPAeTAP..DTKQCHDIVRHIHLGITPCEPVRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.74|      26|      44|      34|      59|       6
---------------------------------------------------------------------------
   34-   59 (48.98/32.34)	WEEFRVTTVSV.PVAYMRWDPSGSHLL
   80-  106 (42.76/27.31)	WEEYGSTALPGeEVLILAWLHNGIQVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20351 with Med16 domain of Kingdom Metazoa
Unable to open file!