<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20323

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAVELGQQTVELGAVVRRAAEESYLALRELVEKSQAEAEGKGIGAGANGGWQRSDTEKKIDLLKFITRTRQRMLRLHVLAKWCQQVPLVHYCQQLGSTLNSHETCFTQTADWLFFMRDDLEKLRAPMFDVPSATEVMLTGGYQRLPRCIEDIGSQNKLSPDEQKRALRKLDASVRYKVLVTPRPKEVSNVSVTDGIAVFRVDGEFKVLLTLGYRGNVDLWRILHMELLVGEKKGPIKLDESRRFALGDDIERRMAASDNPFTVLYAILHEFCISLAMDTIIRQANVLRQGRWKDAIRSELISDSATGQTGNASLMQLVQDGEFDSSGFKIPGLKVNYWLDGKSTSTAEPDSSPFIKIEAGQEMQIKCQHSSFVLDPFTDKEANLSLDLSCIDVEQLILWAIACNRHTRLLTIQRQLCKNVQISQSPKDVILKRDVAAAKDTNKNAGKKGFSDCFGNEVLQVRAYGQAYISLGINIRSGRFLLQSPENILPPAALTDCEETLNKGSTSATEVFSSLRTRSILHLFAAAGRFFGLKVFQQSQGTLKIPETILHGSDLMVMGFPHCANAYYLLMQLDKDFRPVFHLLESQCDASDKTKPNANADAKEVIRCNKINVGQMQVLKNESNTNPFDVKLQALQSIMSSTDLMESDIPVQNGIEPLPLFPACSPSFSSIVDEVFEYECGSTAAHNHSVPPSSLPSTSHLNSLSVGIQGINPRAASPMHDGGGSRTQAINTLKVHPSVSLHSYLPSNFRHIQDINKSLQLVPSSNNNSNQIPVQSSHSGILGNSVSNHLVRPSTTTGGLEKLITAGSDGASRKRSLSDFLPSIPSLQGLQPSEPRKRRKISQSVQSPLPLPAYSSNLQSRASLTCGDVHEERNNYVPATIYASVLLHVIRHCSLCIKHAQLTAQMDSLAIPYVEEVGLRTPSSTLWLRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFRELWELNGGSTMTQWGVGIRIANTSEMDSHISFDSDGVVLTYNTVEADSVPKLVSDLRRLSNARSFACGMRRLIGVKVDDKVDDNQLSTEMKPQSVNKSNSDASEKLSEQMRKMFRIEAVGLMSLWFSYGTMPMVHIVVEWEIAKGGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSSGYSTMPKQANIPTQGPLANGSSSSTIHHAPVPSNAAAAHLGSHNLHAAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPNFMNATQASVHLNNNAGAPQTAPGASRLSATPGVSMSRPTSGVANHVAASLSRAGNAMLASSALASGIGGASVRLTPGAGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELVAAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGFSQAHGDIATAQRARIELCLENHSGSVSADNTESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCISVRLRYSFGDNNHIAFLAMDGSHGGRACWLQLEEWERCKQKVARAVETVNGSAVAGDVGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1738
PositionTail
OrganismPanicum hallii var. hallii
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum> Panicum sect. Panicum.
Aromaticity0.07
Grand average of hydropathy-0.165
Instability index49.76
Isoelectric point8.30
Molecular weight189917.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20323
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.71|      17|      18|    1162|    1179|       1
---------------------------------------------------------------------------
 1162- 1179 (26.35/21.34)	PVTVSSGYSTMpKQANIP
 1183- 1199 (31.36/19.54)	PLANGSSSSTI.HHAPVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      85.72|      21|      24|     728|     751|       2
---------------------------------------------------------------------------
  709-  726 (28.42/11.43)	QGIN.PRAASP...MHD.GGGSR
  728-  748 (36.52/18.57)	QAIN.TLKVHPSVSLHS.YLPSN
  753-  775 (20.78/10.94)	QDINkSLQLVPSSNNNSnQIPVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.36|      17|      18|    1410|    1427|       3
---------------------------------------------------------------------------
 1410- 1427 (26.52/18.38)	Y.GGGWVpLAALKKVLRGI
 1430- 1447 (26.84/13.31)	YlGVLWL.FAQLPELLKEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.66|      17|      18|    1316|    1333|       4
---------------------------------------------------------------------------
 1316- 1332 (31.78/20.55)	ASVHLNNNAGAPQTAPG
 1379- 1395 (31.88/15.53)	ASVRLTPGAGLPVHMKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.45|      14|      18|     985|     998|       5
---------------------------------------------------------------------------
  985-  998 (26.31/15.94)	NTSEMDSHISFDSD
 1005- 1018 (24.14/14.02)	NTVEADSVPKLVSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.47|      23|      23|     935|     957|       7
---------------------------------------------------------------------------
  907-  930 (20.66/ 8.26)	.DSLaipyvEEVGLR..TPSSTL.W.LRL
  935-  957 (43.61/26.07)	DDSW.....KHICLRLGKAGSMS.WDVRI
  959-  981 (36.19/20.32)	DPHF.....REL.WELNGGSTMTqWGVGI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.77|      23|      58|    1280|    1306|       8
---------------------------------------------------------------------------
 1280- 1306 (38.52/36.11)	PSVGGSLPCPQfrpfIMEHVAQGL....NAL
 1340- 1366 (36.25/21.81)	PGVSMSRPTSG....VANHVAASLsragNAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.27|      38|     404|    1228|    1271|       9
---------------------------------------------------------------------------
 1228- 1271 (58.07/62.74)	LVP.......SSLLPFDVSVVLRgpYWI....RIIYrkkFSVDmRCFAGDQVWLQ
 1628- 1676 (63.20/44.69)	LIPhmnvaggAAWLPYCISVRLR..YSFgdnnHIAF...LAMD.GSHGGRACWLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.13|      30|     163|     305|     352|      11
---------------------------------------------------------------------------
  202-  241 (43.36/16.95)	DGEFKvllTLGYR..G.NVDLWrilhmelLVGEKKGPIKLDES
  320-  352 (46.77/30.75)	DGEFD...SSGFKipGlKVNYW.......LDGKSTSTAEPDSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     126.27|      38|     189|     635|     681|      13
---------------------------------------------------------------------------
  547-  567 (32.02/10.88)	ETILHGSDLMVMG............FPHCANAY.............
  636-  681 (64.91/50.59)	QSIMSSTDLMESDipvqngiePLPLFPACSPSFSSIVDEVFEYECG
  848-  867 (29.34/ 9.66)	.....................PLPL.....PAYSSNLQSRASLTCG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.80|      21|      28|     787|     814|      14
---------------------------------------------------------------------------
  787-  814 (26.21/29.46)	SNHLvrPS.TTTGGLEKlitagSDGASRK
  818-  839 (34.59/18.49)	SDFL..PSiPSLQGLQP.....SEPRKRR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20323 with Med14 domain of Kingdom Viridiplantae
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