<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20296

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLGRLVGCCPSDLVRQVYPSKSSAASLPGFTQPTVCQLRGQSYYVEVALGFPAASGDKVSESEHIQIKEEMDSAKDSQLGADGQRKVESPDSLPVLERTFIYPPEAVLVPMVHQAFVRFSSKRMCLQGLLGGSLWEAWPFWNFSPSSYFQNSSFLGSSRGLGVNSNFLRLRRKKNKCNGTASSISSVSSTSDGSERAVATEGDLLADADSMACRQSDMPSNNDNAGSKMVSKRPRSEITEVSSHAGKDVSENVRGANGQVGRPWGWDDEGVVMDINILLSEFGDFSDFFQEEELDFGEPPGTAESHALVIPASDFGDVTFTDSPSTAMDIPEQRLSPVGFTSMDAFDHQTMAPAQDAVSKVQEPQKDIATPAQSQSLVLSSGRFDYLTKAEAMLTFAPEYAAVEVSVAEMPTSLFTNPYLPRSKKPGSSSFSSRVYSYDVTQSSQIEPAGDKPEKPSKLTSGNPLRDVDSSNLYTLVQGRKKESEKSLNSTDMQPSKGEKSPPISGVTSFSSSLVSQKKSDSMFNAGYLLLSMKTALATEIECITFQAALCRIRHTLLSLRSKASAEFNSTMSSFMQTDVSNKSDLTPKYDIRKKEMMPIRLSSDVEHETHDRSLMESVGIWRPIVTPKGSNSLEPLSAKTLTGASPSLSMQRQPVVDLLFAMALLVQQSTSFVDISLDMDDGDGSFFWLSLDEQKRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLCAEVSESSMFSLLQSDIRTALKAAFVNMDGPLSVTDWCRGRSNPAESASSGDAYSFQYSTGDIREPSSTMSIGGDSMSPPQPTSSNRGTSELEHQKGYHRVRPTIAVLPSPSVLVGYQDDWLKASVNGLKTWEKAPFEPYASPKPVTYYALCPDIDMLTSAATDFFLQLGTVYEVCKLGTHSPQNSGGQMELSPGKYLPSGLVLVECPDQLKKVGNNYLSPISSISDYLQAFSKHWSVKSFVTSVSRILRDIKLTSSISTNQKESSSGPCTVIYVVCPFPDPCAILQTLVESSVALGYVILSPERERKSLYFQVAKAQNSSASADEASASNVVMLSGFSIPKLVLQIVTIETVLRIDKPSNELAVLKDIAFTVYNKARRIPRAVSTNDMFQSPTYLGRSQSTMMHVTSPAPTLWKECLVPRMSGPTLSRETDYDAPMRSATWDNSWQPARAGGLLDPSKIPDLFAQDDRKYAFEPLFILADPGSVDPNASMESSKSGSDAGGSGVYGSISGSTSDSSVSPLLDGSESDRAASLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNMRPRDVIITRTGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPEGIPSNSNGPTLQQQDMALIQDRNMPSSPNPLYSPHSKASYMKGGLGQSGNKKQILVEQTGMDSSRGSLHLVRSISLVAVSQDHSLHLTCQADLLTRPASGEGNQGGSGPSSYLEGFTPVKSIGSMPASHSYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTAIPLAMGYVISKAVPPIRRDSAQVTREDRTSVLSVSIIDHYGGSIGTVQEKMSRGPGGSNMSKQARNFTQETSTRDYEMEMHNVLETVAAELHSLSWLTASPVYTERRTALPFHCDMVLRLRRLLHYADRHLTQPAEKGETA
Length1690
PositionKinase
OrganismPanicum hallii var. hallii
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum> Panicum sect. Panicum.
Aromaticity0.07
Grand average of hydropathy-0.318
Instability index57.70
Isoelectric point5.62
Molecular weight183854.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20296
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.09|      28|      60|    1399|    1427|       1
---------------------------------------------------------------------------
 1399- 1427 (48.13/28.92)	QDR..NMPSSPNPLYSPHSKASyMKGGLGQS
 1460- 1489 (47.97/24.42)	QDHslHLTCQADLLTRPASGEG.NQGGSGPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.08|      17|      17|     295|     311|       2
---------------------------------------------------------------------------
  295-  311 (32.38/21.50)	DFGEPP.GTAESHALVIP
  314-  331 (27.70/17.06)	DFGDVTfTDSPSTAMDIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     263.08|      80|     126|     990|    1078|       3
---------------------------------------------------------------------------
  990- 1078 (123.20/92.62)	ISTN...QKESSSGPCTVIYVVCPFPDPCAILQTLVESsvalgyvILSPERERKSLYFQVAKAQNSSASADEASASNvvMLSGFSIPKLVLQ
 1116- 1198 (139.88/85.61)	VSTNdmfQSPTYLGRSQSTMMHVTSPAPTLWKECLVPR.......MSGPTLSRETDYDAPMRSATWDNSWQPARAGG..LLDPSKIPDLFAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     500.34|     160|     729|      36|     249|       5
---------------------------------------------------------------------------
   36-  211 (244.47/163.84)	CqlRGQSYYVEV.....ALGFPAASGDKVSESEHIQIKEEMDSAKDSQLGADGQRKVESPDSLPVLERTF.IYPPEAVLVPMvHQAFVRFSskrmcLQGLlggSLWEAWPFWNFS...PSSYF...QNSSFLGSSrglGVNSnFLRLRRKKNKCN.GTASSISSvSSTSDGSERAVATEGDLLAD.ADSM
  770-  943 (255.88/131.99)	C..RGRSNPAESassgdAYSFQYSTGDIREPSSTMSIGGDSMSPPQPTSSNRGTSELEHQKGYHRVRPTIaVLPSPSVLVGY.QDDWLKAS.....VNGL...KTWEKAPFEPYAspkPVTYYalcPDIDMLTSA...ATDF.FLQLGTVYEVCKlGTHSPQNS.GGQMELSPGKYLPSGLVLVEcPDQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.58|      17|      56|     644|     660|       9
---------------------------------------------------------------------------
  642-  658 (29.23/18.82)	LTGASPSLSMQRQPVVD
  659-  675 (27.35/17.05)	LLFAMALLVQQSTSFVD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20296 with Med13 domain of Kingdom Viridiplantae
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