<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20286

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMEKGDVLVDLDKLPIKRLEAIDEAGNEHYPPDTSNEEQRLAAIRRIDFSWVIEKDAKKAKKAAEADTAQQAWPWQGLMESLQQAQQELSVVIDLIGTVEANDAVAVASTTKPKSQPNEILVDMAVSAATKLQRLRHLSRYFKQSAKTMEQQFQKETRFYNSLIRLQQNWKVKRQRVVGSGPGSEGFLFDLVDSYQLDTTTMPRISPLSLVPIDQDSSGTLSVQIPQKSFRSLSLQFYGDSTYSAESSASKKKEGTLSSTSSEAEKDSLENDDVNKSVKQAHSILRDIHKTIFEEQVFDMVIRETFTQSQGINVTGMCEDFLQLAIGQECSLCLSLVPFGQNSDSETVGQEDHMDTEYSGDLAVATVNGKHDSLNKDLRRFPNPKSLEIYLLHMFHENIVRKIREKSRLVVRYQSPALAAPEECGLLGHFCMTVAHKIFSNKVHLELESVVSRVPYLHLRSLPTWHSRTSSWSLCLKVPQPILAADQITKPSDNNDPKYKSRSQFNTKVILKDGQIRLMGEGSPSIAGSLTGKPSDGRLINCYNCDLEDLPMMLLQQVASQVIHWLHEEAMVLGMNVTRDFLCVYFDLDQGETLGLVAHVDPDDAYGCISWYLTVDHPTEEGKMPADNQELDKRRFLGYLSLEVLYSTLMDLIKMCSTGVQH
Length661
PositionHead
OrganismPanicum hallii var. hallii
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum> Panicum sect. Panicum.
Aromaticity0.07
Grand average of hydropathy-0.394
Instability index48.94
Isoelectric point5.48
Molecular weight74316.45
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblPlants

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
production of miRNAs involved in gene silencing by miRNA	GO:0035196	IEA:EnsemblPlants
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20286
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.19|      23|     139|     330|     357|       1
---------------------------------------------------------------------------
  331-  357 (35.88/31.72)	LClslVPFGQNsDSETVGQEDHMDTE..Y
  581-  605 (39.31/20.85)	LC...VYFDLD.QGETLGLVAHVDPDdaY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     341.25|     113|     252|     203|     320|       2
---------------------------------------------------------------------------
  203-  320 (171.55/127.80)	RISPLSLVPI....DQDSSGTLSVQIPQKSFRSLSLQ...fYGDSTYSAESSASKK...KEG..TLSSTSSEAEKDSLENDDVNKSVKQAHSI.LRDIHKTIFeEQVFDMVIRETFTQSQ..GINVTgmcEDF
  452-  580 (169.70/108.96)	RVPYLHLRSLptwhSRTSSWSLCLKVPQPILAADQITkpsdNNDPKYKSRSQFNTKvilKDGqiRLMGEGSPSIAGSLTGKPSDGRLINCYNCdLEDLPMMLL.QQVASQVIHWLHEEAMvlGMNVT...RDF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.85|      31|     252|     358|     388|       4
---------------------------------------------------------------------------
  358-  388 (55.45/46.88)	SGDLAV..ATVNGKHDSLNKDL..RRFPNPKSLEI
  609-  643 (48.40/39.83)	SWYLTVdhPTEEGKMPADNQELdkRRFLGYLSLEV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20286 with Med17 domain of Kingdom Viridiplantae
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