<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20276

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMHDGLQQARAPIFDVPFATEVLRTGSYRRLPKCIEEIGTQSMLFQDERRPTLKKLNSLVRAKLLETSVPKEISEVSVTDGIANLRVDGEFHVLLTLGYRGHFSHWRLLHMELLVGEKTGPIKLEETRRYALGDDIERRMANTGNPFMILYTVLHELCISLVMDTAIRQANVLRQGRWKDAIKSELISDSSAAQGGNASVQLGQDGELDLSGFRIPGLKLNYWLDENSSGSAEPDLSPFISIEVGKDMQINCLHSSFMLDPLTDKEAYLSIDLSCIDVEALILKAIACNRHTRLLEIQRELSKNGQLLQSPTDVVLKREVNEEGLGKKVDGKNFQNSCTNEVLQVRAYGESYIHLGINIRSGRLLLQSSKNILLPSVLLESEEALNKGSLTPNEVFVNLRIKSILHLFAATGRFLGLKVFSQSQVTLKIPKSVLYGSDFMVMGFPQCTNAYYFLIQLDNNLRPVFHLLETQSDESNSSNADANQVIRFNRIDISCIQTGEDEYSVNLFDTGKALQGIEGGSLRPSGNEKLVPLTPSLSSSFSSLVDEVFEHSTSSSTIENQHFPPSSLPSTHVSSFQVGPEGLCGTACLPELRNSIHSDINTSEVTHDVSLNSDLLSSSSGPARISPMPSDCKSGHGLSSLSSLRGHDISRGGKSLQLVSSDGQRVLGNISTTKLGGPSRKRSLSEIVLNIPSLQQSRISDGPRKRRKASEIMKDSALSKEYSSGKPLTYGNIFTEENRCVTSAIYASVLCHAIKHCSLCIKYAQLTTQMDSLGIPYAEEAELGTPSSNLWLRLPFLKEDSWKHVCLRLGKTGHMSWDVRITDPYYGSLWKVYGGSTTTEWGIGVRIANTSEIDSHITFDDDGVVLTYHTVEAASVHRLVSDLRRLSNTRAFSCGMRRLIGIKVDDKRDEKVTSAETNLHPTTKGSKHRLSEQIRKIFRIEAVGLMSLWFSYVSAPKVHFVVEWEAGNDRCAIHVSPDQLWPHTKFLEDFVNVGEVASFLDSIRLTAGPLLALSIAIRPAKMPVTTTGYSSVPKQNNFRAQGQPANDSSSTTMQNVCAPLSPSGAHPNYHNLQSSMLSATGRGGPGLVPSPSLPFDVTVVLRGPYWIRVIYRKIISVDIRCFSGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNAFEPSYMSARHSGAQLKANANTASGSQQSAPALNRFHGAHGVAISRPTPNVGNQVAPSFTRAGSAMVASSKFASGIAGHPSHLSPGTNLPVHMKGELSSAFTGLGDDGGYGGAWVPLAALKKVLRVILKYLGVLWLFSQFPELLKEILGSVLKENEGALLNLDQEQPALRFFVGGYVFAVSVQRAQLLLQVLNVKRFHHQQQKQQQQAQSPAQEELAISEINEICDYFSRRVACEPYDASRVASFITLLTLPISVLREFISLIAWKKSQSRAHGDIASAQRVRVELCLEKHHVSDSSDHAESSSSSRSNIKHDRANRSVDFGLTFVLDHGLKHHTNIGGAAWLPYCVSVRLRYNFGDNGHVMFLAMEGSHGGKACWLQYEDWERCKQAVVRAMESANGSPAPGETGQGRLRLVAEMIHKQLQLSLQQLRNGPLSAS
Length1598
PositionTail
OrganismPanicum hallii var. hallii
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum> Panicum sect. Panicum.
Aromaticity0.07
Grand average of hydropathy-0.224
Instability index51.20
Isoelectric point8.20
Molecular weight175623.66
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20276
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     182.93|      47|     219|    1231|    1278|       1
---------------------------------------------------------------------------
  563-  589 (41.74/16.33)	................PPSSLP...S.THVSS.FQ.V.GPEGLCGTACLP
  611-  652 (57.22/25.34)	NSDLLSSSSG.PARISP...MPSDCKsGHGLSSLSSLrGHDISRGG....
 1231- 1278 (83.97/44.44)	SSKFASGIAGhPSHLSPGTNLPVHMK.GELSSAFTGL.GDDGGYGGAWVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.41|      21|      25|    1184|    1205|       3
---------------------------------------------------------------------------
 1184- 1205 (32.96/22.74)	TASGSQQSAPALNRfHGAHGVA
 1210- 1230 (37.45/21.03)	TPNVGNQVAPSFTR.AGSAMVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.21|      19|      25|     295|     317|       4
---------------------------------------------------------------------------
  302-  320 (32.02/26.55)	KNGQLLQSPTDVVLK.REVN
 1365- 1384 (27.19/11.30)	KQQQQAQSPAQEELAiSEIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.52|      21|      26|     794|     819|       5
---------------------------------------------------------------------------
  794-  819 (32.78/36.42)	PFLkEDSWKhvclRLGKTGHMSW..DVR
  823-  845 (35.74/21.53)	PYY.GSLWK....VYGGSTTTEWgiGVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     197.94|      57|     114|    1002|    1059|       6
---------------------------------------------------------------------------
 1002- 1059 (95.56/72.23)	IRLTAGPLLALSIAIRPAKMPvTTTGYSSVPKQNNF....RAQGQPANDSSSTTMQNVCAPL
 1118- 1178 (102.37/72.95)	IRCFSGDQVWLQPATPPKGGP.SVGGSLPCPQFRPFimehVAQGLNAFEPSYMSARHSGAQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.72|      52|     878|     400|     454|      13
---------------------------------------------------------------------------
  400-  454 (86.98/58.47)	IKSILHLFAatgRFLG.LKVFSQSQVTLK.IPKSVLYGSDFMVMGFPQCTNAYYFLI
 1282- 1335 (78.74/45.80)	LKKVLRVIL...KYLGvLWLFSQFPELLKeILGSVLKENEGALLNLDQEQPALRFFV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20276 with Med14 domain of Kingdom Viridiplantae
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