<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20274

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVELGAMVRLAAEESYLALRELVERSRAEAEAEAQGKEGVRLRSDTEKKIDLLKFVDRTRQRMLRLHVLAKWCQQVPLVNYCRQLASTLSNHETCFTQTADSLFFMHDGLQQARAPIFDVPFATEVLRTGSYRRLPKCIEEIGTQSMLFQDERRPTLKKLNSLVRAKLLETSVPKEISEVSVTDGIANLRVDGEFHVLLTLGYRGHFSHWRLLHMELLVGEKTGPIKLEETRRYALGDDIERRMANTGNPFMILYTVLHELCISLVMDTAIRQANVLRQGRWKDAIKSELISDSSAAQGGNASVQLGQDGELDLSGFRIPGLKLNYWLDENSSGSAEPDLSPFISIEVGKDMQINCLHSSFMLDPLTDKEAYLSIDLSCIDVEALILKAIACNRHTRLLEIQRELSKNGQLLQSPTDVVLKREVNEEGLGKKVDGKNFQNSCTNEVLQVRAYGESYIHLGINIRSGRLLLQSSKNILLPSVLLESEEALNKGSLTPNEVFVNLRIKSILHLFAATGRFLGLKVFSQSQVTLKIPKSVLYGSDFMVMGFPQCTNAYYFLIQLDNNLRPVFHLLETQSDESNSSNADANQVIRFNRIDISCIQTGEDEYSVNLFDTGKALQGIEGGSLRPSGNEKLVPLTPSLSSSFSSLVDEVFEHSTSSSTIENQHFPPSSLPSTHVSSFQVGPEGLCGTACLPELRNSIHSDINTSEVTHDVSLNSDLLSSSSGPARISPMPSDCKSGHGLSSLSSLRGHDISRGVLGNISTTKLGGPSRKRSLSEIVLNIPSLQQSRISDGPRKRRKASEIMKDSALSKEYSSGKPLTYGNIFTEENRCVTSAIYASVLCHAIKHCSLCIKYAQLTTQMDSLGIPYAEEAELGTPSSNLWLRLPFLKEDSWKHVCLRLGKTGHMSWDVRITDPYYGSLWKVYGGSTTTEWGIGVRIANTSEIDSHITFDDDGVVLTYHTVEAASVHRLVSDLRRLSNTRAFSCGMRRLIGIKVDDKRDEKVTSAETNLHPTTKGSKHRLSEQIRKIFRIEAVGLMSLWFSYVSAPKVHFVVEWEAGNDRCAIHVSPDQLWPHTKFLEDFVNVGEVASFLDSIRLTAGPLLALSIAIRPAKMPVTTTGYSSVPKQNNFRAQGQPANDSSSTTMQNVCAPLSPSGAHPNYHNLQSSMLSATGRGGPGLVPSPSLPFDVTVVLRGPYWIRVIYRKIISVDIRCFSGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNAFEPSYMSARHSGAQLKANANTASGSQQSAPALNRFHGAHGVAISRPTPNVGNQVAPSFTRAGSAMVASSKFASGIAGHPSHLSPGTNLPVHMKGELSSAFTGLGDDGGYGGAWVPLAALKKVLRVILKYLGVLWLFSQFPELLKEILGSVLKENEGALLNLDQEQPALRFFVGGYVFAVSVQRAQLLLQVLNVKRFHHQQQKQQQQAQSPAQEELAISEINEICDYFSRRVACEPYDASRVASFITLLTLPISVLREFISLIAWKKSQSRAHGDIASAQRVRVELCLEKHHVSDSSDHAESSSSSRSNIKHDRANRSVDFGLTFVLDHGLKHHTNIGGAAWLPYCVSVRLRYNFGDNGHVMFLAMEGSHGGKACWLQYEDWERCKQAVVRAMESANGSPAPGETGQGRLRLVAEMIHKQLQLSLQQLRNGPLSAS
Length1698
PositionTail
OrganismPanicum hallii var. hallii
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum> Panicum sect. Panicum.
Aromaticity0.07
Grand average of hydropathy-0.226
Instability index49.98
Isoelectric point8.08
Molecular weight187163.83
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20274
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     226.34|      47|     218|    1331|    1378|       1
---------------------------------------------------------------------------
  676-  702 (39.31/15.97)	................P..PSSLP...STHVSS.FQ.VG...PEG.....LCGT.ACLP
  741-  775 (43.58/18.78)	PSDCKSG.HGL.SSLSSlrGHDISRGVLGNIST..TKLG....................
 1331- 1378 (86.33/48.15)	SSKFASGiAGHPSHLSP..GTNLPVHMKGELSSAFTGLG...DDG.....GYGG.AWVP
 1558- 1606 (57.12/26.93)	SSDHA......ESSSSS..RSNIK.HDRANRSVDF.GLTfvlDHGlkhhtNIGGaAWLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.52|      21|      26|     894|     919|       6
---------------------------------------------------------------------------
  894-  919 (32.78/33.73)	PFLkEDSWKhvclRLGKTGHMSW..DVR
  923-  945 (35.74/19.94)	PYY.GSLWK....VYGGSTTTEWgiGVR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20274 with Med14 domain of Kingdom Viridiplantae
Unable to open file!