<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20273

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMHDGLQQARAPIFDVPFATEVLRTGSYRRLPKCIEEIGTQSMLFQDERRPTLKKLNSLVRAKLLETSVPKEISEVSVTDGIANLRVDGEFHVLLTLGYRGHFSHWRLLHMELLVGEKTGPIKLEETRRYALGDDIERRMANTGNPFMILYTVLHELCISLVMDTAIRQANVLRQGRWKDAIKSELISDSSAAQGGNASVQLGQDGELDLSGFRIPGLKLNYWLDENSSGSAEPDLSPFISIEVGKDMQINCLHSSFMLDPLTDKEAYLSIDLSCIDVEALILKAIACNRHTRLLEIQRELSKNGQLLQSPTDVVLKREVNEEGLGKKVDGKNFQNSCTNEVLQVRAYGESYIHLGINIRSGRLLLQSSKNILLPSVLLESEEALNKGSLTPNEVFVNLRIKSILHLFAATGRFLGLKVFSQSQVTLKIPKSVLYGSDFMVMGFPQCTNAYYFLIQLDNNLRPVFHLLETQSDESNSSNADANQVIRFNRIDISCIQTGEDEYSVNLFDTGKALQGIEGGSLRPSGNEKLVPLTPSLSSSFSSLVDEVFEHSTSSSTIENQHFPPSSLPSTHVSSFQVGPEGLCGTACLPELRNSIHSDINTSEVTHDVSLNSDLLSSSSGPARISPMPSDCKSGHGLSSLSSLRGHDISRGVLGNISTTKLGGPSRKRSLSEIVLNIPSLQQSRISDGPRKRRKASEIMKDSALSKEYSSGKPLTYGNIFTEENRCVTSAIYASVLCHAIKHCSLCIKYAQLTTQMDSLGIPYAEEAELGTPSSNLWLRLPFLKEDSWKHVCLRLGKTGHMSWDVRITDPYYGSLWKVYGGSTTTEWGIGVRIANTSEIDSHITFDDDGVVLTYHTVEAASVHRLVSDLRRLSNTRAFSCGMRRLIGIKVDDKRDEKVTSAETNLHPTTKGSKHRLSEQIRKIFRIEAVGLMSLWFSYVSAPKVHFVVEWEAGNDRCAIHVSPDQLWPHTKFLEDFVNVGEVASFLDSIRLTAGPLLALSIAIRPAKMPVTTTGYSSVPKQNNFRAQGQPANDSSSTTMQNVCAPLSPSGAHPNYHNLQSSMLSATGRGGPGLVPSPSLPFDVTVVLRGPYWIRVIYRKIISVDIRCFSGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNAFEPSYMSARHSGAQLKANANTASGSQQSAPALNRFHGAHGVAISRPTPNVGNQVAPSFTRAGSAMVASSKFASGIAGHPSHLSPGTNLPVHMKGELSSAFTGLGDDGGYGGAWVPLAALKKVLRVILKYLGVLWLFSQFPELLKEILGSVLKENEGALLNLDQEQPALRFFVGGYVFAVSVQRAQLLLQVLNVKRFHHQQQKQQQQAQSPAQEELAISEINEICDYFSRRVACEPYDASRVASFITLLTLPISVLREFISLIAWKKSQSRAHGDIASAQRVRVELCLEKHHVSDSSDHAESSSSSRSNIKHDRANRSVDFGLTFVLDHGLKHHTNIGGAAWLPYCVSVRLRYNFGDNGHVMFLAMEGSHGGKACWLQYEDWERCKQAVVRAMESANGSPAPGETGQGRLRLVAEMIHKQLQLSLQQLRNGPLSAS
Length1585
PositionTail
OrganismPanicum hallii var. hallii
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum> Panicum sect. Panicum.
Aromaticity0.07
Grand average of hydropathy-0.219
Instability index51.18
Isoelectric point8.11
Molecular weight174267.18
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20273
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     168.61|      41|     218|    1218|    1265|       1
---------------------------------------------------------------------------
  563-  589 (43.11/18.01)	................PPSSLP...STHVSS.FQ.VG...PEG.....LCGT.ACLP
 1218- 1265 (68.01/51.09)	SSKFASgiaghpSHLSPGTNLPvHMKGELSSAFTGLG...DDG.....GYGG.AWVP
 1445- 1493 (57.49/28.63)	SSDHAE......SSSSSRSNIK.HDRANRSVDF.GLTfvlDHGlkhhtNIGGaAWLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.58|      32|     218|     907|     941|       2
---------------------------------------------------------------------------
  907-  941 (49.82/39.55)	PTTKGSKHrlSEQIRKiFRIEAV..GLMSLWFSYVSA
 1125- 1158 (58.76/35.66)	PSVGGSLP..CPQFRP.FIMEHVaqGLNAFEPSYMSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.03|      19|      23|     652|     673|       3
---------------------------------------------------------------------------
  655-  673 (30.90/19.16)	NISTTKLG.GPSRKRSLSEI
  679-  698 (26.13/ 8.05)	SLQQSRISdGPRKRRKASEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.52|      21|      26|     781|     806|       5
---------------------------------------------------------------------------
  781-  806 (32.78/31.45)	PFLkEDSWKhvclRLGKTGHMSW..DVR
  810-  832 (35.74/18.59)	PYY.GSLWK....VYGGSTTTEWgiGVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     120.56|      39|     233|     600|     644|       6
---------------------------------------------------------------------------
  600-  644 (59.22/46.82)	NTSEVTHDVSLNSD...LLSSSSGPARISPMPSDcksghgLSSLSSLR
  835-  876 (61.34/34.69)	NTSEIDSHITFDDDgvvLTYHTVEAASVHRLVSD......LRRLSNTR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.41|      21|      23|    1171|    1192|      14
---------------------------------------------------------------------------
 1171- 1192 (32.96/20.87)	TASGSQQSAPALNRfHGAHGVA
 1197- 1217 (37.45/19.29)	TPNVGNQVAPSFTR.AGSAMVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     165.72|      52|     865|     400|     454|      16
---------------------------------------------------------------------------
  400-  454 (86.98/68.89)	IKSILHLFAatgRFLG.LKVFSQSQVTLK.IPKSVLYGSDFMVMGFPQCTNAYYFLI
 1269- 1322 (78.74/54.00)	LKKVLRVIL...KYLGvLWLFSQFPELLKeILGSVLKENEGALLNLDQEQPALRFFV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20273 with Med14 domain of Kingdom Viridiplantae
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