<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20271

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAAELGQQTVELGAMVRLAAEESYLALRELVERSRAEAEAEAQGKEGVRLRSDTEKKIDLLKFVDRTRQRMLRLHVLAKWCQQVPLVNYCRQLASTLSNHETCFTQTADSLFFMHDGLQQARAPIFDVPFATEVLRTGSYRRLPKCIEEIGTQSMLFQDERRPTLKKLNSLVRAKLLETSVPKEISEVSVTDGIANLRVDGEFHVLLTLGYRGHFSHWRLLHMELLVGEKTGPIKLEETRRYALGDDIERRMANTGNPFMILYTVLHELCISLVMDTAIRQANVLRQGRWKDAIKSELISDSSAAQGGNASVQLGQDGELDLSGFRIPGLKLNYWLDENSSGSAEPDLSPFISIEVGKDMQINCLHSSFMLDPLTDKEAYLSIDLSCIDVEALILKAIACNRHTRLLEIQRELSKNGQLLQSPTDVVLKREVNEEGLGKKVDGKNFQNSCTNEVLQVRAYGESYIHLGINIRSGRLLLQSSKNILLPSVLLESEEALNKGSLTPNEVFVNLRIKSILHLFAATGRFLGLKVFSQSQVTLKIPKSVLYGSDFMVMGFPQCTNAYYFLIQLDNNLRPVFHLLETQSDESNSSNADANQVIRFNRIDISCIQTGEDEYSVNLFDTGKALQGIEGGSLRPSGNEKLVPLTPSLSSSFSSLVDEVFEHSTSSSTIENQHFPPSSLPSTHVSSFQVGPEGLCGTACLPELRNSIHSDINTSEVTHDVSLNSDLLSSSSGPARISPMPSDCKSGHGLSSLSSLRGHDISRGGKSLQLVSSDGQRVLGNISTTKLGGPSRKRSLSEIVLNIPSLQQSRISDGPRKRRKASEIMKDSALSKEYSSGKPLTYGNIFTEENRCVTSAIYASVLCHAIKHCSLCIKYAQLTTQMDSLGIPYAEEAELGTPSSNLWLRLPFLKEDSWKHVCLRLGKTGHMSWDVRITDPYYGSLWKVYGGSTTTEWGIGVRIANTSEIDSHITFDDDGVVLTYHTVEAASVHRLVSDLRRLSNTRAFSCGMRRLIGIKVDDKRDEKVTSAETNLHPTTKGSKHRLSEQIRKIFRIEAVGLMSLWFSYVSAPKVHFVVEWEAGNDRCAIHVSPDQLWPHTKFLEDFVNVGEVASFLDSIRLTAGPLLALSIAIRPAKMPVTTTGYSSVPKQNNFRAQGQPANDSSSTTMQNVCAPLSPSGAHPNYHNLQSSMLSATGRGGPGLVPSPSLPFDVTVVLRGPYWIRVIYRKIISVDIRCFSGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNAFEPSYMSARHSGAQLKANANTASGSQQSAPALNRFHGAHGVAISRPTPNVGNQVAPSFTRAGSAMVASSKFASGIAGHPSHLSPGTNLPVHMKGELSSAFTGLGDDGGYGGAWVPLAALKKVLRVILKYLGVLWLFSQFPELLKEILGSVLKENEGALLNLDQEQPALRFFVGGYVFAVSVQRAQLLLQVLNVKRFHHQQQKQQQQAQSPAQEELAISEINEICDYFSRRVACEPYDASRVASFITLLTLPISVLREFISLIAWKKSQSRAHGDIASAQRVRVELCLEKHHVSDSSDHAESSSSSRSNIKHDRANRSVDFGLTFVLDHGLKHHTNIGGAAWLPYCVSVRLRYNFGDNGHVMFLAMEGSHGGKACWLQYEDWERCKQAVVRAMESANGSPAPGETGQGRLRLVAEMIHKQLQLSLQQLRNGPLSAS
Length1711
PositionTail
OrganismPanicum hallii var. hallii
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> PACMAD clade> Panicoideae> Panicodae> Paniceae> Panicinae> Panicum> Panicum sect. Panicum.
Aromaticity0.07
Grand average of hydropathy-0.230
Instability index50.00
Isoelectric point8.16
Molecular weight188520.32
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20271
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     182.93|      47|     219|    1344|    1391|       1
---------------------------------------------------------------------------
  676-  702 (41.74/19.32)	................PPSSLP...S.THVSS.FQ.V.GPEGLCGTACLP
  724-  765 (57.22/29.93)	NSDLLSSSSG.PARISP...MPSDCKsGHGLSSLSSLrGHDISRGG....
 1344- 1391 (83.97/52.41)	SSKFASGIAGhPSHLSPGTNLPVHMK.GELSSAFTGL.GDDGGYGGAWVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.41|      21|      25|    1297|    1318|       3
---------------------------------------------------------------------------
 1297- 1318 (32.96/24.13)	TASGSQQSAPALNRfHGAHGVA
 1323- 1343 (37.45/22.31)	TPNVGNQVAPSFTR.AGSAMVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.59|      22|      25|     408|     430|       4
---------------------------------------------------------------------------
  408-  429 (37.55/27.07)	EIQRE.LSK..NGQLLQ.SPTDVVLK
  431-  456 (26.04/11.21)	EVNEEgLGKkvDGKNFQnSCTNEVLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.52|      21|      26|     907|     932|       5
---------------------------------------------------------------------------
  907-  932 (32.78/38.63)	PFLkEDSWKhvclRLGKTGHMSW..DVR
  936-  958 (35.74/22.83)	PYY.GSLWK....VYGGSTTTEWgiGVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.58|      32|     219|    1033|    1067|       6
---------------------------------------------------------------------------
 1033- 1067 (49.82/37.76)	PTTKGSKHrlSEQIRKiFRIEAV..GLMSLWFSYVSA
 1251- 1284 (58.76/34.03)	PSVGGSLP..CPQFRP.FIMEHVaqGLNAFEPSYMSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.19|      38|     744|     827|     868|       8
---------------------------------------------------------------------------
  827-  868 (58.18/57.66)	DSALSKEYSSGkplTYGNI.FTEENRCVTSAIyASVLCHAIKH
 1570- 1608 (63.01/46.17)	DSSDHAESSSS...SRSNIkHDRANRSVDFGL.TFVLDHGLKH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.38|      18|     576|      43|      60|      10
---------------------------------------------------------------------------
   43-   60 (31.95/27.62)	QGKEGVRLR.SDTEKKIDL
  627-  645 (28.43/23.39)	QGIEGGSLRpSGNEKLVPL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.59|      10|      21|    1395|    1404|      15
---------------------------------------------------------------------------
 1395- 1404 (15.63/ 8.85)	LKKVLRVILK
 1419- 1428 (15.96/ 9.19)	LKEILGSVLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.26|      19|      26|     509|     529|      25
---------------------------------------------------------------------------
  509-  529 (26.93/24.23)	VNLRI.KSIlhLFAATGRFLGL
  537-  556 (29.32/18.45)	VTLKIpKSV..LYGSDFMVMGF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.43|      35|    1372|     281|     316|      26
---------------------------------------------------------------------------
  281-  316 (53.51/40.46)	QANVLRQGRWkDAIKSELISDSSAAQGGNASVQLGQ
 1648- 1682 (64.93/44.92)	KACWLQYEDW.ERCKQAVVRAMESANGSPAPGETGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20271 with Med14 domain of Kingdom Viridiplantae
Unable to open file!