<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20231

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMESPETCLTNVFKIENLSRIPYTLYRNPPPSTPFSIRHAERTLRSEGHIVLGDRESNALWVFQVECFSNGAPRGHGGEGEGGEGRVEGEVQAQIAEESTEGKWKSLERRIREEWGLTESSSGVFLAASLASSTKGGGDIFSPIQLGRSTPVTPAVPTSRPGIFSPSPQDVATIDLTDDPPGEPKEDHLLPYKQFLAAVLSSISFNLSLHNGYTALNIRTLVSPSSLVPHVTESKEDKGDLLPSAPITLPGLLRPSILALEAYLTTSGTFLVTPHTHVQAALRRVSSSLSSSLDKRDVFIAPWGEWGRLVSEEGLKIGAREERWKTSVREYLQDCGILSAPSRQWEEKSILEEAIDGGRWRRVEIWVPIKDHPSEGMGMLVKILWPDTLLFLRTSEGDTDRLRSGDEGCDAFWKKVFDAPEYARFASGRLSRSLAVGVKDKRELGAEWWDIPSAVDWAEEWMDGKDDREKIVMARREEKKRQQQEQERIKREAEAEKEQQSKADEPIPEVKEDGSVKGKLKLLDEAKKDGLATGGNAGVYPTPPDGGQQQQQQQQQPQQQQQQQLPEPSSISSGSSAPNTTSNTTSATAATDMDLDWIDGVMPDAVPDPTRKQSDATGGVGLAGGTGEADLFGGDMDEDMFGGGVTEDDFAFFDNPGQLEGFGGGGDVDMGLDVDFGGGGTVDLAMESPEVTLKEDMLTLVNTPGMPTQNMDQSAEESKTAEPSASDKTEPHIQTPPLSPHRAIRLLVPEYASNPTNSSQHLTPPTTVSAMKTPQKNGGLAPLSGGVNEAKRRMSLYSPITFTTKVEMADRKYAPGGRFFLPESIKEKEQKELEKEQNITTIGLKRKRGGSMFMRSMVVEEATAPEMAEVVLGDEDAVMDDSDGATGEGDDESELYSGDETSSESDADDETDEEEEEPGGGAYYTSPVAVAYGGGIARRKRKRAYEDEDQEMELAPPIPDPTKRDVGVGADEEVGVSGELAPPPWEVMVPDLTESDLVGIFSNISLETEAISLAGLGDNEFATVSRLVRDQIVYGTTKPLGDLMEMTSVETTGEDDDEEWCAIRQRRGKDEGVVEDAVKSLFGKTGVARCTLETYVAIADAVIEPPPLLGRAAAMRPMPQSRRGGIASALAKRPEVEVNTAVFKLPPPHVHIHRAESALEILPPALHFWETFGFGPCSGAKNVIAFCLHPDSRLMEEAADAFLERVSGAYESGRYGVHIRAKLDGVVENGGYGVKGRDIKAVIEAMEDFGSVLANVADEGCNIVVYVVNPFEHPSTLVDICVGFSKLKKVYESRLGGIKGNNLVLQVVRAGFLARKMGAVGTAQAEWARLAAEVYNRCVPSDGVSSLEEAQKIFSPSIYLSRPPPKSIEFKLTTEPSPALLLENSVLHIAYSQSLDERWVSVAWTDNWGTIQSTELYSLGRKNTTILRPFDEVCRDIWNKTLEITSTRKVHWRLVLIKVGEPLQDEINTWTTLASTTTHSLAILSADLNPPVYLIPSLPAPIPTAFNHQVSVYTTPPVTTPTPGSIVSPDQFGNAANTPSADPTPDLDPDSYLVDVCDETWGVILPHRRRLPPDYASGAMAYLIKRGGINDGDELRVLKIELIVAENRGGTIPLLKEVLGWYRDLACLALWKGVVGDGKGNGAPWHLAVAWKAVEGVGWVM
Length1660
PositionKinase
OrganismTuber borchii (White truffle)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Tuberaceae> Tuber.
Aromaticity0.07
Grand average of hydropathy-0.414
Instability index51.01
Isoelectric point4.77
Molecular weight180715.59
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20231
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.11|      20|      28|     872|     891|       2
---------------------------------------------------------------------------
  872-  891 (35.97/20.44)	GDEDAVMDDSDGATGEGDDE
  897-  916 (34.14/18.99)	GDETSSESDADDETDEEEEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.86|      20|      28|     626|     647|       3
---------------------------------------------------------------------------
  626-  645 (41.46/22.36)	GEADLFGGDMDEDM.....FGGGVT
  656-  680 (34.41/12.38)	GQLEGFGGGGDVDMgldvdFGGGGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.38|      29|      30|     702|     731|       5
---------------------------------------------------------------------------
  702-  730 (49.65/31.17)	TPGM.PTQNMDQSAEESKTAEPSASDKTEP
  734-  763 (46.72/23.85)	TPPLsPHRAIRLLVPEYASNPTNSSQHLTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.79|      28|      30|    1583|    1612|       6
---------------------------------------------------------------------------
 1583- 1612 (42.30/29.28)	IKR..GGINDGDELRVLKieLIVAENRGGTIP
 1614- 1643 (47.49/27.19)	LKEvlGWYRDLACLALWK..GVVGDGKGNGAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.52|      17|      30|     811|     827|       7
---------------------------------------------------------------------------
  811-  827 (30.51/20.81)	KYAPGGRFFLPESIKEK
  844-  860 (30.00/20.32)	KRKRGGSMFMRSMVVEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.36|      12|      15|     477|     488|       8
---------------------------------------------------------------------------
  477-  488 (19.81/13.62)	EKKRQQQEQERI
  495-  506 (19.55/13.34)	EKEQQSKADEPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.32|      16|      23|    1508|    1529|       9
---------------------------------------------------------------------------
 1512- 1529 (26.68/20.36)	YTTPPVTTPTPGsiVSPD
 1534- 1549 (28.64/ 7.85)	AANTPSADPTPD..LDPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.26|      11|      28|     577|     587|      10
---------------------------------------------------------------------------
  577-  587 (19.04/12.36)	PNTTSNTTSAT
  606-  616 (20.22/13.68)	PDPTRKQSDAT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.12|      10|      29|    1437|    1447|      11
---------------------------------------------------------------------------
 1437- 1447 (14.71/13.17)	WNkTLEITSTR
 1469- 1478 (19.41/11.88)	WT.TLASTTTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     176.74|      55|     939|     251|     316|      12
---------------------------------------------------------------------------
  251-  312 (81.31/70.15)	LLRPSILALEAYLTTSGtflvTPHTHVQAALRRVssSLSSSLDKRDVFIApWGE.WGRLVSEE
 1359- 1414 (95.43/52.57)	LSRPPPKSIEFKLTTEP....SPALLLENSVLHI..AYSQSLDERWVSVA.WTDnWGTIQSTE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.02|      17|      31|    1177|    1193|      13
---------------------------------------------------------------------------
 1177- 1193 (30.39/21.13)	SGAKNVIAFCLHPDSRL
 1206- 1222 (29.64/20.40)	SGAYESGRYGVHIRAKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.80|      30|      31|     374|     404|      14
---------------------------------------------------------------------------
  374-  404 (48.11/35.22)	EGMGMLVKILWpDTLLFLRTSEGDTDR.LRSG
  406-  436 (49.69/30.96)	EGCDAFWKKVF.DAPEYARFASGRLSRsLAVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.66|      10|      15|     508|     517|      17
---------------------------------------------------------------------------
  508-  517 (16.88/ 6.20)	EVKEDGSVKG
  524-  533 (16.78/ 6.12)	EAKKDGLATG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20231 with Med13 domain of Kingdom Fungi
Unable to open file!