<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20228

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMENGFGVDDLFQDETIPRLSSRRRVDARLDELRLSGCNSKIAWSKVGSIAIINSAGTGVETRHLACNPEDGRWVLSNAYPIANVSRYHENQRLVHVTWNSGAELAVVDVLGRVSFYTVFLAVNHLTATRSQILDQDDDLSALVGFWWLPLEKPYALYRPAARQEDRNFRYQALSYKPFGPFHPIVNKVAAIGITRGGTVKMWYQDGQGRYQEVTAELEGFASLDDLFSHASISCSKDHAAVLAAYTLSKQLRVYRIVINWPQPNQPNQPHTVLPNPPTLVIKHLKIEDCACPADSSTHDVSRAQLTHLETLAPTPAPPDIHTAPGVLAVFTNKKADGEAFSVICRWSLKETPCTLHPSFDQMGVRRTSVSSPTISELYRMDDVVMDKCIIGVSQVTSGTVIALAFSDGSLELRDRYVSQLRDQSTNKNVVMNMMQAGFAFPPGEPCINLALSPNNAVAIRLGPDNDISLIIMEYINGPMEQNDNLEIACVALAHQHAYSCNNLINNDDLLLVAQKYRNPTFNNTFLSEAHRALNLKMDFATESPNERLFRNPLLQRCLSLQNSLDFRGERVNKRLSGKLAWATLHLRVASVAFALTFNNPQRQGQGRDASAASGSGSTSSDFDLRPEALQTLLGLVRWLMDIMSLTISDLFDLSKATKNHTSDLAYVRQKVISGNSPALFLALSSAPRALLRYNCRSLRGLETTAGKHLSSTLSTATDEETRATFRSLKVPIESCAVKISQFERIMTDIDGTIRAAYHNIPEAERAQAEKLLFVNNEIPPIFRVAVERLLNTTLPNLRNDLDIAKLFWHDVTWLGFHDDIASCEYRRRNRIDAIRKVVLPKDDDSSGAGGGKIRLRRCTRCCAVVEDIIPNKSPSQWFGSMQRMCFCGTLWMHIS
Length895
PositionTail
OrganismTuber borchii (White truffle)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Tuberaceae> Tuber.
Aromaticity0.08
Grand average of hydropathy-0.221
Instability index42.80
Isoelectric point7.80
Molecular weight99771.49
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20228
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.71|      25|      28|     521|     548|       1
---------------------------------------------------------------------------
  521-  548 (41.13/32.61)	FNNTFLseaHRALNLK..MDFATESPNERL
  549-  575 (41.59/25.23)	FRNPLL...QRCLSLQnsLDFRGERVNKRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.18|      28|      28|     678|     705|       2
---------------------------------------------------------------------------
  678-  705 (46.98/28.96)	ALFLALSSAPRALLRYNCRSLR.GLETTA
  708-  736 (43.20/26.05)	HLSSTLSTATDEETRATFRSLKvPIESCA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.38|      14|     214|       3|      16|       3
---------------------------------------------------------------------------
    3-   16 (26.80/17.05)	NGF.GVDDLFQDETI
  218-  232 (21.58/12.36)	EGFaSLDDLFSHASI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     138.70|      43|     661|     118|     162|       4
---------------------------------------------------------------------------
  118-  162 (74.24/55.08)	VF.LAVNHLTATRSQILDQDDDLSALvgFW....WLPLEKPYA..LYRPAAR
  781-  830 (64.46/41.25)	IFrVAVERLLNTTLPNLRNDLDIAKL..FWhdvtWLGFHDDIAscEYRRRNR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.23|      10|      28|     615|     624|       5
---------------------------------------------------------------------------
  615-  624 (17.98/11.46)	SGSTSSDFDL
  644-  653 (17.25/10.69)	SLTISDLFDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.59|      34|      39|     442|     478|       6
---------------------------------------------------------------------------
  444-  478 (56.34/44.66)	EPCINL.....ALSPNNAVAI.RLGPDNDISLIIMEYINgP
  480-  519 (50.25/27.47)	EQNDNLeiacvALAHQHAYSCnNLINNDDLLLVAQKYRN.P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20228 with Med16 domain of Kingdom Fungi
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