<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20221

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMTPGDLVDVPGKQTELALRNPRLPHITQGFIELRLLVSRLVQDSHNRLQGMIGLLAEGGRSDGDKKARIIEHMLERRKQFIKLLVLTMWAKNAPAVSEVIDLKVFLDTRQEIFHKVVWNLYEVRRKMSYARIPNPDLDTAVRVLSTGRANTAMTRRYVPPKKLTSRETLKILRDLNTLLSLRLALHEKLPPYFRDYTIASGRATFTVADEFEADLCIGDGDPTSQLYLVDFRFIFKPSAKTLPAGRIRDEVESRGNIILKQKGLEGIYDYLHEFVMTDKICTLFRQFQMMLSGRWTENLVVDMRKRTLVVQYWSGRVTEGATKSWIEVGIKRGTGGRPSHVGVRWIRDGKTVQDQEVPLDVAVLSAESLIKTVIAMHTKHILTLIRGRLAHSPVFPLSAMVLTTHPTDSFNSSLKLQLTPSRPIKFLIEPITGRFALHPPTMVSTQVELSMNNSPTGTEDLIIRLKFILTQEEVETRARSMGWEVLKMLNIRREELKGFFPNSTKYISYLRRKGWGKEWVVAMVLADTGQTWWVAKVHEAPSQWSMSMALEIPVHGEANATYSFLGNLEKMSSAMITLFVNQSMLVEKGVQHKLQPSKVADPKLVIPDLYIRFSSLIHANWGIDVLRLTFQGLGAEGKCIVTVLGRTKEPMTQLGSTNISAADSDVSFHPQSGSYAIRFNINVGESVIEPLIEKLHRIERLIRFVAVIRRFNLPCLDVSLGRIAFTYDTESNSSAEVSFSGDREMKLHLPPRSPHIRIKGFLEHKLNVSGLETVVMALTVTLPLLLAFEKIEAAIGDKSDGHIFVLSRSVDWFRVYYRRLGVVLDWQLQCRKSVLHWFVRDAVSSNSESEGEIVGGEGRRKADELKGIWSGEVEGDWEPLKSGAAARLREVGALAWKIHELIYAGQGAMP
Length910
PositionTail
OrganismTuber borchii (White truffle)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Tuberaceae> Tuber.
Aromaticity0.08
Grand average of hydropathy-0.133
Instability index44.03
Isoelectric point9.45
Molecular weight102827.08
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20221
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.90|      25|     576|     313|     345|       2
---------------------------------------------------------------------------
  313-  343 (32.87/35.15)	WSGRVtEGatkSWiEvGIKRGTGGRPSHVG.V
  869-  894 (44.03/22.18)	WSGEV.EG...DW.E.PLKSGAAARLREVGaL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.25|      33|     728|       7|      40|       4
---------------------------------------------------------------------------
    7-   40 (55.36/34.84)	VDVPGKQtELALR.NPRLPHI.TQGFIELRLLVSRL
  737-  771 (53.89/29.75)	VSFSGDR.EMKLHlPPRSPHIrIKGFLEHKLNVSGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.64|      18|      30|     405|     423|       5
---------------------------------------------------------------------------
  405-  423 (27.65/24.35)	HPTDSFNSSLKLQLTPSrP
  438-  455 (32.99/23.47)	HPPTMVSTQVELSMNNS.P
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20221 with Med14 domain of Kingdom Fungi
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