<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20220

Description Uncharacterized protein
SequenceMSNPHQWARPFQHTQARPQPWSNQPGQDAQNSLARSSRLDIPNVVRPPPARQPPPDPFFQQSHSRTATEKPPVIDLTGSNPSPFQRGLINTPKMDGVFNIPPVTPTVIETPVVVEPVRPYDGALCSRSSIQNSRTRKRLKFAPQACPPASPQFIQPSKVYQGAKNSSTPPALSRGNSSSRQKQIQPQPSKSDFSKPNPRRDNKPKPYLLEAPPGALMFPGSSCSDFFPWKGNHPEDRVTDAQARNGQYDKLYVGKGNASARSSLVPSLKGKSALPSLSSLFLTVLDKRQKYNRLTTPPTFKPPPRVTLPDMRREAWLRDLASPLVPLRRLSRTIPHGLKGPILLDQCAAKSIPTARAVWFARCVGANELRGLKRKGVGSFAVGSETKWLKEWTGQVTRFLERTISECGSSSDLWKQKMVYAVRLSAHLFGENLLDRTLFLEWYLSYLETCSLDMLPMAYLMLSIYWDELLKTRRLGRRLAEALLGKAEAILATEDKEIYAPLMQKLSILLTDILFSHRESLIVSNSWELYQSILEACVDKRCSIVRSCLQNISQRNKNLLSPMQARQNGSVSSGQRKLINMLDSIAMPYNIDEIWGKCRSLEVEEDQLVRCLCQWATTSLRVGKHRIYIIAGLLGCARRGGINVQDHMKSFLEGFGSNVKGSKDDAYLLVSELVRSKTFSVALYMKWLISRGILSEYTITQESPCHVRLLAEVSVTSAPSHIRNLRSILLSDHGFSVEDEARSLEVSKQILSSKMPRVFYGDSRAGVSVEKFTTEELGYFGSLNRAVIYELGLWIRENVRKHVVKGAPVGRDNWRDLSVEVGITAVRTEEFVMIRQLLEMFKDFLILAEVVKMVTSSDSSATLSSAADTVSYNIEVFSSLGAVKDNLQLLYNRYKKLQMRRTLEKYVLVSLVDLASFPGAQADIRRELESELANYDKRFPRASVTHSPVSENMGDMFEHGTADSNEEIDRLLRNGATIDKHNLSRLFETIVSRMETSFDDRESVGALSSSAAYLIKLRQFDPLVFDELMCGWVTRLLQSSSRPPLLQTLSVLVAGSCLQLDVIVQATLSVLRPQAKSSNPATGEIAAQTLDILVNDGTDGLSLSPFELYSLKRKRKLFTLKFVDKFVQLIRQSIQICAVASSPDTKNRVRGLILSPPVLEFLRGLATAQPDILISDIVEPLSKTAETSLLQWLRVLIDHLLDDQENGGLYPLFFPFESSVMVAYIGLDNTDLDPEVQVAHLIQYANDFSIGLCQLKMRIIFDAENKNASFRPSGDHTGSSENPLMKPFFQGIASTFKDRVTIWTDLVSVLNQECAYQVFHAHIRGYAEELVLNSPTFPPVRLCLGPLEPSLAEGRESGETLARALLSVIEATAYSIPKQGIASIATLLVDKLNMIIQSITLQEDELEKAEHAAVPEVFWNDSLAESRCWYVYFF
Length1434
PositionKinase
OrganismTuber borchii (White truffle)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Pezizomycetes> Pezizales> Tuberaceae> Tuber.
Aromaticity0.08
Grand average of hydropathy-0.215
Instability index51.12
Isoelectric point8.84
Molecular weight160498.35
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20220
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     156.82|      37|      39|      98|     134|       1
---------------------------------------------------------------------------
   53-   93 (44.20/19.20)	........PPPDPffqqshsrTATEKPPVID.LTGSNPSPFQRGLINTPK
   98-  134 (65.42/31.73)	FN.....IPPVTP........TVIETPVVVEPVRPYDGALCSRSSIQNSR
  139-  174 (47.20/20.97)	LKfapqaCPPASP........QFIQ......PSKVYQGAKNSSTPPALSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     217.96|      77|     217|     843|     925|       2
---------------------------------------------------------------------------
  843-  925 (113.84/97.21)	DFLILA..EVVKMVTSSDSSATLSSAADTvsYNIEVFSslGAvkDNLQL....LY..NRYKKLQMRRTLEKYV.L....VSLVDLASFPGAQADIR
 1061- 1150 (104.12/71.56)	DVIVQAtlSVLRPQAKSSNPATGEIAAQT..LDILVND..GT..DGLSLspfeLYslKRKRKLFTLKFVDKFVqLirqsIQICAVASSPDTKNRVR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     197.35|      41|      42|     434|     474|       3
---------------------------------------------------------------------------
  324-  368 (48.82/28.99)	LVPLRR...................LSRTIphGLKGPI.LLDQ..CAAKS..IPTAravW.FA..RCVGANE
  369-  427 (33.10/17.14)	LRGLKRkgvgsfavgsetkwlkewtGQVTR..FLERTISECGS..SS.DLwkQKMV...YaVR..LS...AH
  428-  468 (71.08/45.77)	LFGENL...................LDRTL..FLEWYLSYLET..CSLDM..LPMA...Y.LM..LSIYWDE
  469-  512 (44.36/25.62)	LLKTRR...................LGRRL...AEALLGKAEAilATEDK..EIYA...P.LMqkLSILLTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.04|      20|     107|     180|     213|       4
---------------------------------------------------------------------------
    9-   25 (27.41/ 8.34)	..RPFQH...TQARPQPW..S.NQP
  193-  213 (34.62/42.45)	FsKPNPR...RDNKPKPYLLE.APP
  300-  323 (29.01/ 6.75)	F.KPPPRvtlPDMRREAWLRDlASP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.61|      31|     503|     651|     688|       5
---------------------------------------------------------------------------
  651-  688 (39.63/45.97)	FLEGFGSnvkgSKDDayLLVSELVR..SKTFSVALyMKWL
 1161- 1193 (48.98/30.75)	FLRGLAT....AQPD..ILISDIVEplSKTAETSL.LQWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.47|      21|     293|    1024|    1044|       6
---------------------------------------------------------------------------
 1024- 1044 (40.67/22.01)	VFDELMCGWVTRL.LQSSSRPP
 1318- 1339 (35.80/18.57)	VFHAHIRGYAEELvLNSPTFPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.90|      12|      14|     243|     255|      11
---------------------------------------------------------------------------
  243-  255 (17.88/15.67)	ARNGQYDKLYvGK
  260-  271 (20.02/11.94)	ARSSLVPSLK.GK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20220 with Med12 domain of Kingdom Fungi
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