<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20211

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRVIDGFSNIYWRIYTEEQNATNTLADAPNNGHTILKHISRLKELELRLRSLGCLVLSYPRRLGLLIFSATSEFEHLLPLLANEGRDEPNRLLIGSTILKVWTSGSVTAGDLVKSLCPESQTPGVNSSTGSQRLQNGSMPPRRVDTSGGSAAIYASFISAVTAAFSLQLIRQNNAIPLGPRTLYNAVECDLYEGLDIVNNDPTSVSVLTTLQAQLTSVGKLTITLQTIAQTGLTRLSQPRDPLELSDVSPGTDLWLAPNGSIARLVTLSPVAGNTPNSLANSEGIGHDRASTKRWKSNALEWLSYFGLPVDCVEEENWVEVEVWEPFYAKLSGEAARPNEENPRIPLKRLLWPAIYCFRRTKSSISEPCDMMEGISPFACDPLEFAEKWCFTEIPKAILEPSVKLVPDHQDRQTNDQGTLSPGLPGFPDGIESLSRASLYPELQTASLVYPTPPDGAAGTGPSHPVSSDVFVEDLDHGSSFALKQTKPRLDSQPITRNRSDPDVTMGFGPSAGLVVGSGLYDTNGDDDLFGDMNERDFGTKGITDEDFSFFDEPGFENMGNNPPDDDIDGISDFVDPIKPEDIAHPEPDAPQSHEPPVEETYVRQPSPDEQKPLLPCEQPVPHDTAALPSPHDEQVQTISPPLSPVEVKKFLFPEPDAHDETSIKTGQPPSFYSPIKFKQNLSSWDQKYGAEGKFWFMSSGASRIKDSPSLSGDIPTVGLPRGRGRLNHAGIYLKARDAQGSPSSEMVQESPSSLGSSSETGDDSDDSGAENIMSPAVLSARKRKRARSNSGTSLALSSEKPPTTIDQDMSTPRTDDSVFLGNFLSTFADWSMTGFFSSTENQVFPVLTSRETQVQVAQLFVDQVTQSSLDHKLDGNFGVSCLQNQPFFLRGLLEGTEFLGGVEKLDLNGFVTLQETNSLSPPASNGPVVARQTPQRRDAGKGLIVKLSPPHLRVRRGKDFLETLPPAVSFWETFGLEPAHGPKNISAYCIHPNIAGKAADAFLERLGVIYSSCNLGNHARGDKSDAFEQGLRAWDVTSSGQSGYHSVMQHLKAICEELGTALLNGPPSKDNIVVYIINPFLHAASLVDICFAFWSLFRRYIADADKQQTKQFDELVLQVIPMSFVASPESLVVPPQPEYLSLALEVYSRCPPKPVQSSLLSCAPPVLIAEPLPGSIGFRLVSERSSPLQEGKCLHIACSRSQDQRWVSVAWSDNTGALQRSMSYCVRFRNSIAPRTIFTVRNEIWAATIDIMEKNQARWRVIIVSTENVDQDEHDTWLNFADQYNKIKSVPIELTVLSVNTTPDLFLSSPLPQIPMSIFNQHPSATPVTTPNPGIFSPDQLGNAPTPPGAGNFPANASTPTDALLEAEGESMLTDICDESWGIVLSHRLNSTLHLTEYRPALVSGYLLRRKGTSDSDGAFAMNVNLLYTQRPSSANETLLREILGMYRDLATLARARGTRIVQSSTLPWHIATAVRAQEILSYVL
Length1496
PositionKinase
OrganismAspergillus ochraceoroseus IBT 24754
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.08
Grand average of hydropathy-0.313
Instability index50.73
Isoelectric point4.99
Molecular weight163585.89
Publications
PubMed=29317534

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20211
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.25|      70|     144|    1116|    1197|       1
---------------------------------------------------------------------------
 1116- 1197 (99.72/98.11)	DKQQTKQfdelvlQVIpmsfVASPESLVVPPQPEYLSLAlEVYSRCPPKPVQSSLLS..CAPPVLIAEPLPgSIGFRLVSERSS
 1264- 1335 (113.53/75.47)	EKNQARW......RVI....IVSTENVDQDEHDTWLNFA.DQYNKIKSVPIELTVLSvnTTPDLFLSSPLP.QIPMSIFNQHPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     683.40|     144|     144|     460|     603|       2
---------------------------------------------------------------------------
  337-  452 (115.96/50.74)	...........................FYAKLS.GEA.ARPNEENPRI...PLKRllwpaiycfRRtkssiSEPcDMMEGI.SPFA....CDPL.....EFAEKWCF.TEI..P.......................KAILEPSVKLV..PDHQDRQTNDQ.GTLSP..GLPGFPDGIESLSRAslYPE
  454-  597 (237.49/112.03)	QTASLVYPTPPDGAAGTGPSHPVSSDVFVEDLDHGSS.FALKQTKPRLDSQPITR.........NR.....SDP.DVTMGF.GPSAGLVVGSGLY...DTNGDDDLF.GDM..NERDF.................GTKGITDEDFSFFDEPGFENMGNNPP.DDDID..GISDFVDPIKPEDIA..HPE
  598-  741 (158.13/72.01)	PDAPQSHEPPVEETYVRQPSP...........DEQKPlLPCEQPVPH.DTAALP..........SP.....HDE.QVQTIS.PPLSPVEVKKFLFpepDAH.DETSI.KTG..QPPSFyspikfkqnlsswdqkyGAEG....KF.WFMSSGASRIKDSPSlSGDIPtvGL.....PRGRGRLN..HAG
  747-  882 (171.82/78.91)	RDAQGS...PSSEMVQESPSSLGSSSETGDDSDDSGA.ENI.MSPAVLSARKRKR.........AR.....SNS.GTSLALsSEKPPTTIDQDMS...TPRTDDSVFlGNFlsTFADW.................SMTGF....FSSTENQVFPVLTSR...ETQVQ..VAQLFVDQVTQSSLD..H..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     461.93|     149|     892|      32|     197|       4
---------------------------------------------------------------------------
   32-  197 (218.01/144.49)	TNTLADAPNNGHTILKHISRLKElelrlRSLGCLV.LSYPR...RLG...LLIFSATSEFEHLLPLLANEGRDEPNRLLIGSTILKVWTSGSVTAGDLVKSLCpesqTPGvNSSTG..SQRLQNGsMPPRRVDTSGGSAaiYASFISAVtAAFSLQLirqNNAIPLGPRTLYNAV
  927- 1084 (243.92/124.08)	TNSLSPPASNGPVVARQTPQRRD.....AGKGLIVkLSPPHlrvRRGkdfLETLPPAVSFWETFGLEPAHGPKNISAYCIHPNIAGKAADAFLERLGVIYSSC....NLG.NHARGdkSDAFEQG.LRAWDVTSSGQSG..YHSVMQHL.KAICEEL...GTALLNGPPSKDNIV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20211 with Med13 domain of Kingdom Fungi
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