<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20203

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSAFLKSAAPLGTLNSELVNPPPRPEALITDVKSVSRGWRLQNFDAAANKLLKCAARLETEVQAETRYWNGVLAVKEKGWKVCRLPREGQALGVQYGFLEATPIFRDRGLAALRRTDDGNLVLDKGLMPQKAQAVRVRVKSRGRVTGCSKAYRPTKQAESIERRILQARDTLFEEELFHELVREARILGSQGVTTRQNLVQLPVSEEQEILLDLVDGEDMTSNEDASDSSEHDVLADVLAHSIRILLSYSHRQNHRRRTQPPPPISKNRRPAPEYHILRPIIAYLQHDSHVRWLESFMKDIHGVLNSAGLKCEFHATPFASIGTLQPNKSVPTVEALVRVFLTPFESTFSGNLVTPQSFFKVRVRTNPAVPPFGTHYDISINLPQNPDVQPPTRIGLQDEVAAVITHFIMLDITSAIALQSPQIGQDILNSHQETASKVSWEVAYPHHGELLAVTSTGQSKKMKVSLSRQELALQIYSSGRADDINQPIAAKSPTLQSQTWKPNLGGSHPSVMDFVARVSQT
Length522
PositionHead
OrganismAspergillus ochraceoroseus IBT 24754
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.06
Grand average of hydropathy-0.352
Instability index53.82
Isoelectric point9.01
Molecular weight58096.46
Publications
PubMed=29317534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20203
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.25|      21|      27|      53|      79|       1
---------------------------------------------------------------------------
   28-   50 (30.12/ 9.46)	LITDVKSVSRGWrlQNFDAAANK
   58-   78 (36.13/33.67)	LETEVQAETRYW..NGVLAVKEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.51|      22|      28|     375|     399|       3
---------------------------------------------------------------------------
  375-  399 (29.88/33.09)	THYdISINLPQNPDVQPPtRIGlQD
  406-  427 (39.63/25.84)	THF.IMLDITSAIALQSP.QIG.QD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.91|      24|      25|     452|     475|       4
---------------------------------------------------------------------------
  431-  467 (30.32/18.12)	SHQETASK.vswevayphhgelLAVTSTGQSKKMKVSL
  468-  505 (32.58/19.98)	SRQELALQiyssgraddinqpiAAKSPTLQSQTWKPNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.09|      15|      25|     125|     139|       5
---------------------------------------------------------------------------
  125-  139 (25.25/15.80)	KGLMPQK.AQAVRVRV
  150-  165 (20.84/11.86)	KAYRPTKqAESIERRI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20203 with Med17 domain of Kingdom Fungi
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