<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20199

Description Mediator of RNA polymerase II transcription subunit 6
SequenceMAGTQEPSSLEEILWRSPPHVQMMGGYLHSNNILFYFAESPFFDATSNNASLAIQANYNEAFRHFVETREAFEGRLKTMQGLEFVVAYDPLQAAAQSNTQFARDPSNIWVIRKQTRRKRAGLDDEVVVLATFFVVGDCIYMAPSVASVVGNRIVRELLLLGCFFFSTSAANIVLVLLSAVTSLTSLLKTASTLPIFTPSHGHTYLPPAPKSTDPSQPGVQSQGSKENTPMPDVDASSKAAAALVSSQAQQTSGSTFQDLKTLAESFNLLSRYGDEFMDENPLVGEPGSFILSKAGDTDRGATAKQPPPPSTIPGRVATPQVKVDTPGKTSEKAAPSGAEESKLRRKKSKLGS
Length352
PositionHead
OrganismAspergillus ochraceoroseus IBT 24754
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.08
Grand average of hydropathy-0.236
Instability index48.68
Isoelectric point6.54
Molecular weight37965.44
Publications
PubMed=29317534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
ECO:0000256	PIRNR:PIRNR013286
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20199
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.21|      18|      21|     253|     273|       1
---------------------------------------------------------------------------
  255-  273 (27.88/23.86)	TFQDLKTL.AE..SFnLLSRYG
  275-  295 (24.33/ 9.18)	EFMDENPLvGEpgSF.ILSKAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.88|      12|      21|     138|     149|       2
---------------------------------------------------------------------------
  138-  149 (21.91/15.94)	CIYMAPSVASVV
  162-  173 (21.97/16.00)	CFFFSTSAANIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.93|      21|      24|     199|     222|       3
---------------------------------------------------------------------------
  202-  222 (39.46/24.04)	HTYLPPAPKSTDPSQPGVQSQ
  227-  247 (34.47/13.10)	NTPMPDVDASSKAAAALVSSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.84|      12|      25|     296|     308|       4
---------------------------------------------------------------------------
  296-  308 (18.98/14.54)	DTDrGATAKQPPP
  324-  335 (21.86/11.67)	DTP.GKTSEKAAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20199 with Med6 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GDEFMDENPLVGEPGSFILSKAGDTDRGATAKQPPPPSTIPGRVATPQVKVDTPGKTSEKAAPSGAEESKLRRKKSKLGS
2) TYLPPAPKSTDPSQPGVQSQGSKENTPMPDVDASSKAAAALV
273
203
352
244










Molecular Recognition Features






MoRF SequenceStartStop




1) GRVATPQVKVDTPGKTSEKAAPSGAEESKLRRKKSKLGS
314
352