<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20197

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSNRASSASFRVGPPSPSSPAAFSLKENSLTASPPGQIPQTPTSPPLMSGSASNNASSFASLQASPSQATSQPANLSSPPSSTPMSTQASQQPTAGMTNSFPTPASSVDPDHIDKSFGASVSEIGAPSAASTSAAPSQQSEHRRTDHDRNFEGSQATTGVRDLANMASSTQAHHGDAMDIDTDNPNWPSLDSLQRDFSSAFHLCKSSHIATGPDPTLDLISLYGLGPVAKSVARMDPVTGEKINRLRKSYEGKLKGLGLAGRNKPVKIDSTTAGGLRHMTMWPEEEWQNQKVYGKEIKVADIDSALYNLQMKAMKMESGTVPNNDYWEDVLGHEKPAKHVSNGEVAKKVAAAPNGVRVPTQTNGSSAPTDQERSRPSRGRKRHYDDNSFVGYGEGYADDDDDGAYYSNGEGVGKKKRKKDHVSKISTPLPERGGSYGVGMFGIGAR
Length446
PositionHead
OrganismAspergillus ochraceoroseus IBT 24754
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.06
Grand average of hydropathy-0.757
Instability index47.52
Isoelectric point7.22
Molecular weight47291.52
Publications
PubMed=29317534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20197
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.47|      28|      31|      16|      46|       1
---------------------------------------------------------------------------
   16-   45 (47.31/28.65)	S..PSSPAAFSLKENSLTASPPgqIPQTPTSP
   81-  110 (44.16/17.00)	SstPMSTQASQQPTAGMTNSFP..TPASSVDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     130.39|      29|      31|     114|     142|       2
---------------------------------------------------------------------------
  114-  142 (48.49/22.37)	DKSFGASVSEIGAPSAAS.....TSAAPSQQSEH
  148-  174 (41.78/18.38)	DRNFEGSQATTGVRDLA.......NMASSTQAHH
  176-  208 (40.12/17.39)	D.AMDIDTDNPNWPSLDSlqrdfSSAFHLCKSSH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.26|      21|      32|     261|     281|       4
---------------------------------------------------------------------------
  261-  281 (37.81/23.21)	GRN.KPVKIDSTTAG.GLRHMTM
  294-  316 (27.45/15.07)	GKEiKVADIDSALYNlQMKAMKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.80|      13|      49|       2|      14|       5
---------------------------------------------------------------------------
    2-   14 (24.61/13.17)	SNRASS.ASFRVGP
   53-   66 (19.19/ 8.73)	SNNASSfASLQASP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20197 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDGAYYSNGEGVGKKKRKKDHVSKISTPLPERGGSYGVGM
2) MSNRASSASFRVGPPSPSSPAAFSLKENSLTASPPGQIPQTPTSPPLMSGSASNNASSFASLQASPSQATSQPANLSSPPSSTPMSTQASQQPTAGMTNSFPTPASSVDPDHIDKSFGASVSEIGAPSAASTSAAPSQQSEHRRTDHDRNFEGSQATTGVRDLANMASSTQAHHGDAMDIDTDNPNWPSLDS
3) PNNDYWEDVLGHEKPAKHVSNGEVAKKVAAAPNGVRVPTQTNGSSAPTDQERSRPSRGRKRHYDDNSFVGYG
400
1
322
440
192
393










Molecular Recognition Features






MoRF SequenceStartStop




NANANA