<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20195

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMGSAEQWGIFLHRCLIDRVDAGEFRDLTKLLSQRFPITEWALIDTLLETRLFTRIKWDPLVPLYVDCLCKMGKVQISTALTSLLKFSSIHDKPQSPGADANQLKKNSKCYTLMTDIRVIQDAMLSVSTGSATKTLTEAIHTFSAAVDWIQAVVSWHNNHIDPSQQTGGLMSSTDAVLLFESLGILLAALSGTAKGLEVLSADSHEALKIQLGQALSAYLPLCVEVSLPLRNRLDSLQKEFSLYGQPQSKSLEVSMMDNVHVNALQFEASVIDGPVISSRAGLYVYINSMLFGRPLVDDSILLSYLTNRYGGHYEVLIEEVITASFDVLSNAMYRNESGRTMFLFRSFLVNKLPTFFAAMLTVSMVSLPMEVCISHALSRLDPNAFPSFSQMFSMQGNTVLSDVRQEFLFSCASHKLIPESSIERLLGENPMQTLPVGGPYIKDDLVSQITSNPERAEQLISDIESTEGNASAIVGAITEVMHNLCNQRETMTLKNICNSLSRRPQSLDVILLFRSPKQVLQPLCALLDSWHWDEDQGESQPVYDEFGSILLLVLTFKYRYDLRPFDLGITSENSFVLRLIERGSCCQKLDELNEKQNKNLGEWIAALFIAEGISEETMSACSPQEFYMLVSTLFNQSLGACEAGKLEFDTLKGGFEFVDLLEPFLLPSLVFALTWLGNHIWESEQDPTIPLKTLQSLVNPSSISGEAREIHLTVLNITARSLEEQLKDVRARHPSRMDIKPILDALEPCLSFQRTGSCRRSELESWTTHSPGGLLGSIRSTFQSLVLWSTSPDVSMAPLSYTHRQVVAGIRMLGAPRVFNSLLEELKLQSEAGSGDLALDVAATIVCAPLAESFAVEQNNHHPVDPTKEPVPRTPILTLRDALNLQHENVPKMSEKDPLRAEVIVRLYRRVNSLMTPPAQVTNLDMSNIIQNMQLGVDTPAPMGLHTSGADGTGAQHATANINQIMDNAAAAVGMDSGQGMAGMAGMEGMGLDTSDEGLDPSIDDVLNAADMNPEFLDLDMEGMFQ
Length1026
PositionTail
OrganismAspergillus ochraceoroseus IBT 24754
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus> Aspergillus subgen. Nidulantes.
Aromaticity0.07
Grand average of hydropathy-0.027
Instability index47.62
Isoelectric point4.87
Molecular weight113213.25
Publications
PubMed=29317534

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20195
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     425.72|     145|     234|     373|     551|       2
---------------------------------------------------------------------------
  373-  551 (210.67/237.38)	IS.HALSRLDPNAFPSF.SQMFSmQGntvlsdvrqefLFSCASHKLipessierllgenPMQTLPVGGPYIkdDLV......................SQITSNPERAEQLISDIESTEGNASAIvgAITeVMhNLCNQRETMTLKNIcnsLSRRPQSLDV..ILLFRSPKQVLQPL..C..ALLDSWHWDEDQGESQPVYDEFGSILL
  613-  787 (215.04/156.87)	ISeETMSACSPQEFYMLvSTLFN.QS...........LGACEAGKL.............EFDTLKGGFEFV..DLLepfllpslvfaltwlgnhiwesEQDPTIPLKTLQSLVNPSSISGEAREI..HLT.VL.NITARSLEEQLKDV...RARHPSRMDIkpILDALEPCLSFQRTgsCrrSELESWTTHSPGGLLGSIRSTFQSLVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.58|      27|      48|     911|     938|       4
---------------------------------------------------------------------------
  911-  938 (42.15/38.52)	VNSLMTPPAQVTNLDMSNIIQNMQlGVD
  962-  988 (46.43/36.90)	INQIMDNAAAAVGMDSGQGMAGMA.GME
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.45|      11|     624|      30|      40|       5
---------------------------------------------------------------------------
   30-   40 (20.68/14.27)	LLSQR.FPITEW
   46-   57 (14.78/ 7.97)	LLETRlFTRIKW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20195 with Med5 domain of Kingdom Fungi
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