<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20192

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMSDPAGEIVHITQGYIPLAKVLTRLAQSTHNALQDQIAALAKMPVPTTAMNGNSTIPNSDVEDASSENIAKKTSILNFAMKEHRKWVKALVITEWSRKADMVSQLIDLRFHLQGQEVLFTGALDVMGHVKRDLTFARMPSPDLKTALQVLSTGEAAWMPDLSYIEPPPLTREEEIQWMSDVNTQLSLRLNLEDFDKIPYPFRNYEIDSGRVTFKVSGEFEVDLTIADEDFEKQFWFIDFRFAFRPAASSIPEGLKNYLESHVNDILSKDGLLGCYQFLHELVLTHKLNELKRQANQMSRGSWTGTLKVEPLNRALAIQYWTSRTQPGTPKSWVLVAVTSGKKANGQPDPKLSSHLTAKWYRDNKEVKEEKIAFDTDNLSAETLMKTVIGRHIDFLLGSVHSKLLSFPRFQNRQAAMVLRTSQDDPAASSLAMRVGFKDSATLLIEPTTGVFAVKPHSKFTWSPENQLNNGKNPAEDGAACLENVRCAVMEDELSRRGSTTGWSIKRSPLNKDELRSLTNTREWTKTIWLHRAGWETNWFVMVLLSPSGDVWWLVDVNRNASGQAPRLASKLPLNKGYPRLDDEFWNNLTLFASGMIAQAVDQRELHKQNIKFKPHGANNWSLPQQVRLPTLEIALSGIFPSMVFDNAEKDNPKTAGATESGKLGPIVRSASASGISTKQPWANDIVSVRFKGVQPAEARPTGPESAKTGDDKSEVPFTCVSDAIIKVRRPAKFAMLKSHMVGRDVSWNARTGEFCLRMRSSIGQSMLESLKARVKAVDRFVSFFESMDKAKEWIVAESVSLKEVTFSYGPQAPEASNKAQPSRLWRITLNLSQNDIDLVMGETNPHLPVTNLMQKLVNGANGIGALMNWLPESLPALEAVKKIRETWRDVEARHQGRFRFMMDSVDEMSIQYSLAGTVPGNHLVHREITFLAHIKHRRGEPWWHIMRKPLNGASTPDDEFSKALKPVWEATGEKWTGLVTGAAGRPHDGTASLLLAIDEAIRPLAGSSFQNNSEVVVLE
Length1019
PositionTail
OrganismFusarium culmorum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.08
Grand average of hydropathy-0.372
Instability index36.02
Isoelectric point8.44
Molecular weight114019.67
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20192
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.65|      43|     139|     730|     774|       1
---------------------------------------------------------------------------
  730-  774 (71.42/49.91)	PAKFAMLKSHMVGRDVswNAR.TGEFCLRMRSSIGQSMLESLKARV
  875-  918 (72.23/43.38)	PALEAVKKIRETWRDV..EARhQGRFRFMMDSVDEMSIQYSLAGTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.28|      36|     139|     639|     681|       2
---------------------------------------------------------------------------
  639-  681 (59.45/59.13)	FPSMvfdnaekDNPKTAGATESGKLGPIVRS..ASASGISTK.QP...W
  784-  825 (51.83/35.89)	FESM.......DKAKEWIVAESVSLKEVTFSygPQAPEASNKaQPsrlW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.63|      20|     139|     157|     179|       3
---------------------------------------------------------------------------
  157-  179 (31.59/31.34)	WMPDLSyIEppPLTREEEIQ.WMS
  302-  322 (34.05/19.75)	WTGTLK.VE..PLNRALAIQyWTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.02|      63|     129|     206|     277|       5
---------------------------------------------------------------------------
  206-  277 (92.12/88.15)	IDSGRvtfKVSGEFevDLTIADEDFEKqfWFIDF......RFAFRPAASSIPEGLKNYLESHVNDIL....SKdgLLGCYQF
  337-  409 (97.90/65.14)	VTSGK...KANGQP..DPKLSSHLTAK..WYRDNkevkeeKIAFDTDNLSAETLMKTVIGRHIDFLLgsvhSK..LLSFPRF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20192 with Med14 domain of Kingdom Fungi
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