<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20182

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMTSRTPMGAHPRPPQRSVSSSSLPVQRPPPQRTLSHQQQFVPASPVRKDSSFIDLTADAGDVTPNRYNTTPRRGGSRLRLELSHNASTGPLPTSESPQSLTPSRIPADPFQTMVGSPVPINSANSTSMPMPTRRPVASQLRSAPPITTTTAPALAKKDTRPKPYTVEVPSAAPRYFAANRPETTPRNPVDPFSKGLNSGYADFFPWNGAHYEDEWSSEAITKGTWDKVNLNVPETSSAKLAIFPALKQKTGLNALSTIFMGVLTQRRHRGQINAPSTFKPPPRVTLTDTKREVWLKDLANPVISLRRLSRTIPHGIRGRTLLDQCLNKNVPAERAVWLAKCVGANEIRGLKRKGVNGAFVMGGELKWARDWTVFVEQFVDAVVTGFSEKDWKNRVTYAVRLATNLYSEQLLDRDHYLDWIVSGIENSLQSRIPMWLLIAQIYWKDLLRFRKYGRRLVFALLSHLHVIYNDPDQDLLVQLSSRLSTLLSSLVLSNPESFINPGAWPRYKNTLQAFLRTDHEPTQKSLHIINSRNSRLVVSSTASPPAGRSQLVKLLDAALKESGDDHLAATCWATSENKPLIMKTVVEWATSFHRPGLAKVYAAARLIRQWSQFRVNPTTPILETLDSISIEDKTRKNLIYHLVTELIRTGHFSVSQYMQWTIARGGYHSGAEIDADSGPCSSRLLVELPLHALSEKKRAERGNLLRRAGNYSIVEEEQDIANAIKFVRHTVGLPLPPGDPLSERKPVSLKRLLPRISSSSGALRSSIGAHLRDVLTSQFNHNSQPSLPLTMYNSIRAIMETAEDYSMLSDILGACSKTADYDVLASVADTVHSNLQIFSALGSANELFNVLIERLKSMNEEQGIVPRPLLASLSSLAQRMAGHEVVASHLRQELLLSDRSNAVDACSPVSDIVAAPTQHAENELAEDIEKQLSSGTRLDPPTMNKLFRRIIPALERGWEKMDDTRRVFATLLTRIRVFDAHHFDKLMTDWTSHVRSLPNRSALVSLFPLLVSTGCLTMPILMSTASPPSASFQNSSSDPSGNKFGPATYLQELLQLSIMPLPSGTGLFAEENYRFNTEQKCAKFEQSKGLLNLVRNALLEYSGLRNHANSPEFPLDNPACQESLLETLRTLVLVDSSAVSNALGIKSLPAEAVGLVRKVTTKLLIPGDSGDTQISFDHILQIANELTLPFCQLKLNLDLSLPQPNANEGDQGSSRFEVFAKAMDRAIEAGNIMWTSLLPCLSDDITQHLKSQAQSVFLELIPSSKAPECADTGSRQSLRMAENLLEVVEAIISGQPPPKMAQLSLGMVEKLTDLWEIIAAGPHERPNCYTAVLQHWLPAMLRFVTLHSLSSEPPSAPLPTASATRPPIPPVHDTRARIILVLCGLLLELDTISPAIAGSLPQQVFDIAILLVDALPEDLRANCAKAILLTSGGLPSQGTSSDPRLYYLFSSPPPSLSDNLMLSHREKAANPQSALARGMGAQYGIGPAVQERLTPFVLRRWEVLSEPTPNVGENDTSLSLGLFEAIKLQ
Length1529
PositionKinase
OrganismFusarium culmorum
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium.
Aromaticity0.06
Grand average of hydropathy-0.231
Instability index51.45
Isoelectric point8.86
Molecular weight168483.65
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20182
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     176.61|      39|      97|    1317|    1355|       1
---------------------------------------------------------------------------
 1317- 1355 (72.56/38.62)	IIAAGPHE.RPNCYTAVL..QHWLPAM.....LRFVTLHSLSSEPPS
 1411- 1455 (49.40/23.96)	LVDALPEDlRANCAKAILltSGGLPSQgtssdPRLYYL..FSSPPPS
 1474- 1509 (54.66/27.29)	ALARGMGA.QYGIGPAVQ..ERLTPFV.....LR..RWEVLSEPTP.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     220.83|      56|      97|     806|     873|       2
---------------------------------------------------------------------------
  806-  863 (80.67/59.58)	SMLSDILGACSKTADYDVLASVADTVHSNLQIfsALGSANELFNVLIERLKSMNEEQG
  907-  962 (95.09/70.72)	SPVSDIVAAPTQHAENELAEDIEKQLSSGTRL..DPPTMNKLFRRIIPALERGWEKMD
 1281- 1316 (45.08/25.29)	.............AEN.LLEVVEAII.SGQ....PPPKMAQLSLGMVEKLTDLWE...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.33|      30|      47|     683|     712|       3
---------------------------------------------------------------------------
  683-  712 (51.45/27.94)	RLLVELPL...HALSEKKRAERGNLLRRAGNYS
  728-  760 (46.89/24.80)	RHTVGLPLppgDPLSERKPVSLKRLLPRISSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.45|      12|      15|       6|      19|       4
---------------------------------------------------------------------------
    6-   19 (17.26/14.41)	PMgAHPrPPQRSVS
   24-   35 (25.19/10.80)	PV.QRP.PPQRTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     215.16|      50|      91|     453|     502|       5
---------------------------------------------------------------------------
  453-  502 (80.90/50.97)	GRRLVFALLSHLHVIYNDPDQDLL...VQLSSRLSTLLSSLVLSNPESFINPG
  506-  546 (61.30/36.67)	..RYKNTLQAFLRT.DHEPTQKSL...HIINSR....NSRLVVSSTAS..PPA
  547-  596 (72.96/45.18)	GRS...QLVKLLDAALKESGDDHLaatCWATSENKPLIMKTVVEWATSFHRPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      96.47|      25|      25|     119|     143|       6
---------------------------------------------------------------------------
  119-  143 (44.17/19.51)	PINSANSTSM.PMPTR.RPVASQLRSA
  145-  171 (30.30/11.29)	PITTTTAPALaKKDTRpKPYTVEVPSA
  173-  189 (22.01/ 6.37)	PRYFAANRPE.TTP.R.NPV.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.19|      13|     104|     888|     903|       8
---------------------------------------------------------------------------
  888-  903 (17.73/18.12)	SHLRQellLSDRSNAV
  992- 1004 (22.46/12.77)	SHVRS...LPNRSALV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     128.45|      41|      95|     296|     338|      11
---------------------------------------------------------------------------
  252-  282 (28.79/12.49)	..................LNALS.TIFMGVltqrRHRGQINaPSTFKPPP
  289-  331 (70.43/48.72)	TKREVWLKDL..ANPVisLRRLSRTIPHGI....RGRTLLD.QCLNKNVP
  332-  357 (29.23/13.38)	AERAVWLAKCvgANEI...RGLKR...KGV....NG..............
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20182 with Med12 domain of Kingdom Fungi
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