Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDTYIDGRFERLEKALANLIDSVTKFHPSIHQGDELDAADKELTKGLEEVQTHQNNYLRIQQLRESSAALDTQIRETLSNLATTRKDIVTTHTTTFPAGPSYAIAYEELLNYARRISKTTMPPAGTIKAVPATVAPPTPEGQTPGAQTPGPDSQTASVMTPSAPPSSQVQSPAVMNGTPHVSQDPATQQSAMSANTSLPSEWTQFLNPLTDQIFLPWPNDLQLGAGALAAHQVLLEQGINPKGYDPAEEEERKRLEEEERKKKEEEDRIAQEEREKKLREERERQRIERERQREKDQEAWRRASLVGGPAAPGEQRSPTGPPQQKAQFQFTNLDDLDDDDDDD |
Length | 343 |
Position | Middle |
Organism | Fusarium culmorum |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Nectriaceae> Fusarium. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.969 |
Instability index | 56.06 |
Isoelectric point | 4.82 |
Molecular weight | 38253.67 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP20174 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 41.97| 14| 15| 256| 269| 1 --------------------------------------------------------------------------- 256- 269 (24.21/13.68) EEEERKKKEEED..RI 272- 287 (17.77/ 8.33) EEREKKLREERErqRI --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 92.52| 25| 27| 120| 144| 2 --------------------------------------------------------------------------- 120- 144 (46.46/23.73) TMPPAGTIKAVPATVAPPTPEGQTP 148- 172 (46.06/23.47) TPGPDSQTASVMTPSAPPSSQVQSP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 83.09| 27| 28| 30| 56| 3 --------------------------------------------------------------------------- 30- 56 (45.03/35.50) IHQGDELDAA.DKELTKGLEEVQTHQNN 60- 87 (38.06/28.80) IQQLRESSAAlDTQIRETLSNLATTRKD --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) PPQQKAQFQFTNLDDLDD 2) QEAWRRASLVGGPA | 321 297 | 338 310 |
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