<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20171

Description Uncharacterized protein
SequenceMTSRTPIGVHPRPPQRALSSSTLPSVQRPPPQQRALSQQLFPSSPIRKDPILSDASSDSFDPAQAQSHGPNQGQGQGQAHARLVTTPRRVGSRLRLELSNIDPVAGSAPSASLSASASASVSAASSPQSHTTSRVPSMADAADAGDSSPAPSRASAADVDNDNQPLPMPRRRPPTLQTYPELSRRLAAPSRAAPALKKDGRPKPWTVEVPKGAPRYPSTEKRPNPAGGDPFSRGLFSGHADFFPWHGGNGKHHEDDWSPEAIQKGTWDRGNQNETSSARMTISPAIKQKSGLSALSTIFMGVLNQRRHRGRVTAPSTFKPPPRVTLTDTKREVWMKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKSVPTERAVWLAKCVGANEIRAFKRKGAPGGAFAIAGEFKWIRDWTVFVEQFIEAVTSAFGEPDWKAKVTYAIRLATNLYAEQLLDRDHYLDWITSGLEHSPQSKIPMWILIAQICWADILRSRKYGRRLVYSILGHLHTIHTHPDKDILIQLSSQLSTLLGSLIKNNSDSFIDPGLWQKYKDALEAFLPRDDKAGREAYHHVGARNGQVSITTTASPAAGRPQLIRLLDATLLGQIDRDLPQKCWATGDDKADIVRTTVDWATSIYRPGLARVYIAANLIKVWSTLRINVTATILEHMDTIPAGDGGPKQMVYHLVTELVRTGQFLVSQYLQWLVARGACSHPSEVDSDDAPCTTRLLVHLPIRYLTEDQKDDRANLLRRAANYSAAEEASDISNSLMCVNHTLGLPVQGDAMAGRRPMPLRKLLPRILSSSKALQTAVGLHLRETVLRLVKSVQPISLRMFSAIRTILEATQDFYALCDVLKLCSRTTNIEVLASCVDTVNLHLQVFYAQGGAERLFTIFFERLKAINQEQGLVSRPLLAALCFLSRRMPSRQELSKYLAHELAQSDRNNATDACSPISDNMVNPPSGADGEVSEQIEKLLASGNSIDHPTMNRLFGYIIRRLEAGWAKMDDNRRVHASLLTRLRLFDAQHFDKLMSDWVGRVRLLKSRQRLDAVFPLLIITDALPVSFLVGPASLTQAPPSGDAEAAAATTPNLATPGAVTYLQELLHLILSRLPADSDLNQEEAYRFGIYQRAIQLNHYKGLLALIRNAAVEYADLQPRVGDAKLPLDDGTYRESVLDALRLLVVVHTADVTEAFSSKNIPTAGFRLIHEMISSLLQREGHLGTPFAAAYDEILRLTNELTMPFCQIKLNMDLSISPCRPTESEDGQPQRSPSQFDLFAKAMDRAIEAQNIMWTTMLPCLSEDISRHLQSQARSRFLALVPTSTSLSSSKAPSNLQNAPANSNNLYLAEKLLGVIEAIVVGQPPPNTAQLNSVVADRLSDLVEIVVAAKGHDDKTEGMLVPIFEHWLPMLLRFVLLHSVSVEPLSASVMTTSAQGKLVMPPHHEARAHTVLALCRLFLALEALPSRLVGGGLRQRVFDVTMVLADGLPDDLRLQCAKSILLLPGMMPGLHTSSDSRLHYIFSVPQMSSTDTLMLAHREKTTMPHSTAARGMGAMYGIGPASQERLSPYVLRRWELLSEPTPNVGVNDTSLSLSLFEAIRLH
Length1592
PositionKinase
OrganismTrichoderma longibrachiatum ATCC 18648
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.225
Instability index50.06
Isoelectric point9.10
Molecular weight175225.47
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	ARBA:ARBA00002895
ECO:0000256	ARBA:ARBA00003744

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20171
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     179.61|      58|     204|    1233|    1312|       1
---------------------------------------------------------------------------
  721-  780 (95.66/49.59)	CTTRLLVHL...PIRYL.TEDQKDDRA....NLLRRAANYsaAEEASDI..SNSLMCVNHTLGLPVQGDA
 1236- 1303 (83.95/82.13)	CQIKLNMDLsisPCRPTeSEDGQPQRSpsqfDLFAKAMDR..AIEAQNImwTTMLPCLSEDISRHLQSQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.14|      52|     123|      24|     146|       2
---------------------------------------------------------------------------
   24-   80 (91.98/139.54)	PS................VQRPPPQQRA...LSQQL.............................FPSSPIRKDPilsdASSDSFDPAQAQSHG...PNQGqGQGQAH
  151-  253 (67.16/15.22)	PSrasaadvdndnqplpmPRRRPPTLQTypeLSRRLaapsraapalkkdgrpkpwtvevpkgaprYPSTEKRPNP....AGGDPFSRGLFSGHAdffPWHG.GNGKHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     243.73|      89|     128|     924|    1050|       3
---------------------------------------------------------------------------
  884- 1003 (119.36/105.28)	RLFTI.FFERLKA..INQEQGLVSRPLLAA...LCFLsrrmpsrqeLS.KYLahelaqsdrnnatdaCSPISDNMVnPPSGaDGEVSEQIEKLLASGNSIDHptMNRLFGYIIRRLEagwAKMDDNR
 1014- 1112 (124.38/72.36)	RLFDAqHFDKLMSdwVGRVRLLKSRQRLDAvfpLLII......tdaLPvSFL...............VGPASLTQA.PPSG.DAEAAAATTPNLATPGAVTY..LQELLHLILSRLP...ADSDLNQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.94|      42|     577|     811|     876|       6
---------------------------------------------------------------------------
  340-  382 (71.66/38.68)	NPaISLRRLS..RTIPHGIRGRTLLDQCLNKSVPTERAVWLAKCV
  823-  866 (69.27/60.93)	QP.ISLRMFSaiRTILEATQDFYALCDVLKLCSRTTNIEVLASCV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     192.35|      63|     578|     557|     626|      10
---------------------------------------------------------------------------
  557-  626 (91.41/71.91)	PRDDKAGREAYhhVGARNGQVSITTT.........ASPAAGRpQLIRLLDATLLgQIDRDLPQKCWATGDdkaDIVRTT
 1157- 1228 (100.94/56.57)	PLDDGTYRESV..LDALRLLVVVHTAdvteafsskNIPTAGF.RLIHEMISSLL.QREGHLGTPFAAAYD...EILRLT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20171 with Med12 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FFPWHGGNGKHHEDDWSPEAIQKGTWDRGNQNETSSARMTISPAI
2) MTSRTPIGVHPRPPQRALSSSTLPSVQRPPPQQRALSQQLFPSSPIRKDPILSDASSDSFDPAQAQSHGPNQGQGQGQAHARLVTTPRRVGSRLRLELSNIDPVAGSAPSASLSASASASVSAASSPQSHTTSRVPSMADAADAGDSSPAPSRASAADVDNDNQPLPMPRRRPPTLQTYPELSRRLAAPSRAAPALKKDGRPKPWTVEVPKGAPRYPSTEKRPNPAGGDPFSRGL
242
1
286
235










Molecular Recognition Features






MoRF SequenceStartStop




1) PIRKDPIL
2) RAAPALKKDGRPK
3) RLRLEL
4) YPELSRRLA
45
191
93
179
52
203
98
187