<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20170

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMIMDPRNTAREALRDSVKCWSDFVSKCLTKRLDAGPFEDYVKLIFARHPLTPEVIADFLLQPQASNCVSPDPRIPPYISVLTQLRYIDAVSILRSLYRYSSLHTQTPLQAQGQDHDQDRDQDHQQEEREREKEKEREKDGEEEGKDATAKEHGHEKTLPGDTKHEAQQDTLRPSRTRWKSSSWLEEVMFYHVIRLVVEGTASKDSRTALELIHVTSKWMSLFAAASNSMAAEMLSGTLQDPQVRHDMEVSRAAFVPLLLRLVDNPALVKVISHPSAKAPRKEFSDSLTSFVHVFQPVPPFVEKLEMFRTEVLAPLDPVEKNNQAANAMDELLDSTVGLDNLMIPDMPITNTRAGLYVYLGASLVGRPLIDDHAFFSYLNNRYQGNNQQSAIDLILASFDLLANAVFRNEGPRDAHLLRSFLTNKVPLILGQLCPPGFSTPSAEFCITQALSQVDTSVFPTASLMFDESRNNNPYTESVREEFCSACALHGLIEREHVERILGESSMSYEPSQEKYFKEKLVQSCLSDPDKIQALVRDMDKMDGNVGAVCQALVELLRQLCNSKDTMSLKILCSQLVQKPQSLDVLLLFEKLPTILDPICQLLDGWRYDEDQGEYQPVYEEFGAILLLVLAFAYRYSLYPADIGILATDSSVAKIIGRAHISRGLDRLSEQEHGHLGGWIHGLFDSDAGGLGDDLMSSCPPAEFYLLIATLFENIVIAYTQGSLTDDALKSGVEYLVDTFLLPSLIPAIRFLSDYLWVEQREQKSVIKILQLILLPTSISGEASTMLASVKGIVAKPLEHSLRAYQRQDPKNQDIEPLLRALKDSLPHSRRTGAAEHQELEMWTASSSSGLAGAAKHLIQNLVQWGMHPQMTAMPTSYTHRQIIATLKIVGASRLLRVMLEEIRQQTLAGSGSIAYDVVTALVCAPNVSNELPLTSGLLDETGSLPPPLQRRLTLREVLKMEAENYRRLHKKDPELAEITVRLYRRVEAQLVLPPPPTMLQAADMQLDLAGDATGLGGPMAAAGGVQGDGTMAIDSAGNLDMSIGGVSADMGLGASSNNGGLDASAEADLFGGLDTDMDVFDGWSGMDLGGP
Length1091
PositionTail
OrganismTrichoderma longibrachiatum ATCC 18648
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.07
Grand average of hydropathy-0.202
Instability index43.87
Isoelectric point5.04
Molecular weight120680.05
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364142

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20170
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.46|      20|      20|    1023|    1042|       1
---------------------------------------------------------------------------
 1023- 1042 (36.16/24.41)	GGVQGD.GTMAIDSAGNLDMS
 1044- 1064 (29.98/18.82)	GGVSADmGLGASSNNGGLDAS
 1071- 1088 (28.32/17.32)	GGLDTD.MDV.FDGWSGMDL.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.10|      15|      20|     283|     302|       2
---------------------------------------------------------------------------
  287-  302 (24.41/26.13)	LTSF.VHVFQPVPPfVE
  304-  319 (22.68/ 7.22)	LEMFrTEVLAPLDP.VE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.00|      11|      20|     832|     842|       3
---------------------------------------------------------------------------
  832-  842 (23.05/15.76)	GAAEH..QELEMW
  852-  864 (17.95/10.62)	GAAKHliQNLVQW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      28.84|      10|      19|     950|     967|       4
---------------------------------------------------------------------------
  950-  967 (11.27/32.47)	RRLTLRevlkmeaeNYRR
  976-  985 (17.57/13.66)	AEITVR........LYRR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.33|      16|      19|     429|     444|       5
---------------------------------------------------------------------------
  429-  444 (31.35/16.01)	LGQLCPPGFSTPSAEF
  450-  465 (27.98/13.59)	LSQVDTSVFPTASLMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.94|      18|     167|     411|     428|       7
---------------------------------------------------------------------------
  387-  408 (18.42/ 7.91)	QQSAidLILASFdlLANAVFRN
  411-  428 (31.52/18.19)	PRDA..HLLRSF..LTNKVPLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.56|      48|     361|     331|     378|       8
---------------------------------------------------------------------------
  331-  378 (87.76/48.27)	LLDSTV.GL.DNLM..IPDMPITNTRAGLY.....VYLGASLVG................RPLIDDHAFFS.YL
  682-  755 (53.80/26.97)	LFDSDAgGLgDDLMssCPPAEFYLLIATLFeniviAYTQGSLTDdalksgveylvdtfllPSLIPAIRFLSdYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.20|      20|     361|     545|     582|       9
---------------------------------------------------------------------------
  545-  564 (33.07/44.72)	VGAVCQALVELLRQLCNSKD
  584-  603 (33.12/ 9.98)	VLLLFEKLPTILDPICQLLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     151.32|      51|     675|     199|     264|      12
---------------------------------------------------------------------------
  199-  264 (65.93/86.72)	GtASKDSRTALELIhvtsKWMSLfaAASNSMAAEMLSGTLQDPQVRHDMevsraafvPLLLRLVDN
  890-  940 (85.39/62.63)	G.ASRLLRVMLEEI....RQQTL..AGSGSIAYDVVTALVCAPNVSNEL........PLTSGLLDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     159.43|      50|     535|      92|     160|      13
---------------------------------------------------------------------------
   92-  160 (74.33/81.07)	ILRSLYRYSSLHTQTPLQAQGQDHDQDRDQDHQQEEREREKEkerekdgeeegkdataKEHGHektLPG
  628-  677 (85.10/53.90)	VLAFAYRYSLYPADIGILATDSSVAKIIGRAHISRGLDRLSE................QEHGH...LGG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20170 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) TQTPLQAQGQDHDQDRDQDHQQEEREREKEKEREKDGEEEGKDATAKEHGHEKTLPGDTKHEAQQDTLRPSR
104
175










Molecular Recognition Features






MoRF SequenceStartStop




NANANA