<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20168

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTGEYETNTLLVNNVSSIAYRLYEPGPNLSQNFASTALDVENSLRERGYVVLYDATKRGLWHFQFLPKDASLDDLGDSLELPPDVTGQGLAVKEHGVIEPPIIQKPRSQAPQSSITPTGPLSTSSPLEQAHRPALSSPLQTTAPASQEQDLKVDAKLKATIAQRTLYEKFITSVLSTLSTTFCRRMGAIPLNYRTVLLSPTAYDAQPHAVAVARPQILGTFRVNLTTTGAMMISLALTKCRGILSLDDAVPSGLAPPGYSVLAAPFGIMTAAQSSVSGGDGSTSLAQTPMTQFFNFRGGVDGQESVWKQACLRFLNFRGIAATTLEGCLWVNLLVPKPKNPDSRGDQRLASTNSSFTLPWPRRLCFRKKNVDISSTSRVVDAVLSGHEESHDPLGNARGWYASVTEREEKAKRAMERAANILKEQNQQAESKTPRLSGLSPVALQRPNTATAGIMYPTPPDGVHQPNGVTPSLDGTLSSPGNPLSAPVVTEADAIVQNEPPNGDSLDQPLEFAESKRQRGDSNLLGDDDQIFGGDVGGDIFDDNDITEADFNFFDERPGDIATDMPMADMPGSELALPPPPQTVEGAVILGDTAPHPPVSMPAPLPHHPPAPFSASTAAQAATPAFAPIPPLPPPPHATLPPPPPPASQDRAVFAKPELKHARSQNEDQGRRNRGDIRVTPAKRESSPFDPYAVFKRVRASLKMPNHDSQGASQPTSRKAKIFESLDFDPALPLINKKYEQGGFYDPSALSKVEKMEKPNSDHRAVPETDYLKRHGKVNRRARERPMTRGAMNKPYSAFELQGSTGSPMKLDGSISEGEDSSLESDQDDSSYASDESGSPHKASIRLINGDDDILSQITSLRDGDIEEPDHQLAMELPRLSKSDTSGPPLSSLFSDPEPLTLDMALSDDDMIQIAQIVTEQAATGGLDIFRASEFEPPTLSASQKRQELSNYGRDAFHTLEEVVAQFFGDTMPMRLKGLLDIQDLPLLSQFQPRQMPGREGNSEAMKPGNLYQIPSPHLEVQRADTKLSVLPSAVSFWESLGLSPSSGSKNINAICVFPGWPGMGDNVQTFLDRVKSVYEFLKLGTFEIMPLGADMDPGLLPYEVDRITTSPDATVTGHGSAMIESLEALRGLFTNLSVTETNFVVYFVYSPDNPGTIIESCLAFQRFFETYQKILATRKEPPQNELVLQLVSADMLSSPTALVVTPTSELIRLCIETYDRCTLFGGSMPAPAIRLEQLLPRIIDFKLTTNPSASLIRENSCIHVAYAQSVDERWVTAAWTDDRGNQQATAAYCLARKGKSPSRNMNDVAHEIWETTLELISAWKVLWRVIITKCGPMPQHEMDFWVDLARTEINAKVTVALLTVDTNPSLQLLPPVVRLPPPTAALHTPVSTPQPNVLSPEQIATPATPAREANMTAATPSGDGGAPNTSTADADSDAILVDVTDQTWGAIAGHRLSNSTSILEVQPALISGYLIKRTGIRVEDAPVAMEVNLVYTEAMPRVHEPLFREMLGYFRGLGTLARARGVVDREADVRPWHVAAAEKAARALYLLM
Length1554
PositionKinase
OrganismTrichoderma longibrachiatum ATCC 18648
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.337
Instability index46.32
Isoelectric point5.14
Molecular weight168890.72
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20168
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.99|      18|      18|     280|     297|       1
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  280-  297 (34.17/19.75)	G.DGSTSLAQTPMTQFFNF
  300-  318 (30.82/17.11)	GvDGQESVWKQACLRFLNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     224.63|      53|      54|     531|     583|       2
---------------------------------------------------------------------------
   55-   85 (43.40/13.39)	.................DAT.KRGLWHFQFLPKDASLD...............DL.GDSLELPPD
  529-  581 (97.25/38.41)	DDQIFGGDVGGDIFDDNDIT.EADFNFFDERPGDIATDM...........PMADMPGSELALPPP
  582-  646 (83.98/32.24)	PQTVEGAVILGDTAPHPPVSmPAPLPHHPPAPFSASTAAqaatpafapipPLPPPPHATLPPPPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      80.65|      28|      33|     445|     475|       4
---------------------------------------------------------------------------
  445-  466 (21.69/14.81)	...........LQRP.NTATAGImypTPPDGVHQ
  467-  498 (34.41/15.12)	PNGVTPSLDgtLSSPgNPLSAPV..vTEADAIVQ
 1417- 1434 (24.54/ 7.48)	MTAATPSGD..GGAP.NTSTA.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.27|      15|      15|     722|     736|       6
---------------------------------------------------------------------------
  722-  736 (26.57/14.35)	KIFESLDF.DP.ALPLI
  738-  754 (17.70/ 6.67)	KKYEQGGFyDPsALSKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.45|      29|      33|     797|     829|       7
---------------------------------------------------------------------------
  797-  829 (45.65/34.19)	YSAFElqgsTGSPMKLDGSISEGED...SSLESDQD
  833-  864 (45.80/25.22)	YASDE....SGSPHKASIRLINGDDdilSQITSLRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.34|      11|      24|     874|     885|      10
---------------------------------------------------------------------------
  874-  885 (13.95/11.14)	LAMELPrLSKSD
  901-  911 (18.39/ 9.41)	LTLDMA.LSDDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     187.94|      76|    1272|      86|     222|      11
---------------------------------------------------------------------------
   91-  151 (33.50/60.28)	.........................................LAVKEHGVIE..PPIIQKPrsqaPqssitPTGplstsspleqahRPALSSPLQTTAPASQEQD
  175-  214 (32.06/24.77)	VLSTLSTTFCRRMGAIPLNYRtVLLSPTAYDAQphaVAVA................................................................
 1327- 1414 (122.37/63.61)	VLWRVIITKCGPMPQHEMDFW.VDLARTEINAK...VTVAlLTVDTNPSLQllPPVVRLP....P.....PTA...alhtpvstpQPNVLSPEQIATPATPARE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.13|      19|      33|     331|     349|      12
---------------------------------------------------------------------------
  331-  349 (33.90/19.64)	WVN.LLVPKPKNPDSRGDQR
  361-  379 (32.30/18.35)	WPR.RLCFRKKNVDISSTSR
  380-  399 (24.94/12.38)	VVDaVLSGHEESHDPLGNAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.94|      32|      33|     647|     679|      15
---------------------------------------------------------------------------
  647-  679 (50.44/32.17)	PASQDRAVFaKPE..LKHARSQNEDQGRRNRGDIR
  682-  715 (51.50/28.77)	PAKRESSPF.DPYavFKRVRASLKMPNHDSQGASQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20168 with Med13 domain of Kingdom Fungi
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