<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20162

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMMSFHPQTPQSPSQFSPATSSDPSLGSSGSVVAAGSGTTTLPTPAHSVNGSSSQIEHMMLDDSPHKRKRPLEDVGDDREPKKAHVEDGKLALEDLHLDVGPKYLLLQSPHPESLPRTSEDLYEMFDLTGLAAEVAREKPNGEKNALRKTYKGHIKRLGVTGHFDVQKKKEDSPSDFLAMLQVPDHEWNVHQVKGRALMDGLSEMTRSSLSRALTMAKGPIAKSVWDTSVLGDIGSNGDSSKAPSAKPTAPNTPLISMPGAAMNRPKAQLLPGQNPARPQRSIKKRSYGDSSFEGYGEGFPDDDTGLETGYSTGEGEGGQKRRKKSSGTTPPYPSAMRQSSYGPGMVGV
Length348
PositionHead
OrganismTrichoderma longibrachiatum ATCC 18648
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.05
Grand average of hydropathy-0.771
Instability index53.80
Isoelectric point7.20
Molecular weight37330.31
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364151

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20162
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.00|      16|      52|     272|     288|       1
---------------------------------------------------------------------------
  272-  288 (26.02/16.36)	GQNPARPQrSIKKRSYG
  327-  342 (31.97/16.13)	GTTPPYPS.AMRQSSYG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.93|      16|      23|      62|      84|       2
---------------------------------------------------------------------------
   62-   81 (24.52/16.52)	DSphkrKRPLEDVGDDREPK
   87-  102 (28.41/13.48)	DG....KLALEDLHLDVGPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.65|      21|      22|     157|     177|       4
---------------------------------------------------------------------------
  157-  177 (36.84/24.88)	LGVTGH.FDVQKKKEDSPSDFL
  180-  201 (34.82/23.12)	LQVPDHeWNVHQVKGRALMDGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.64|      12|      25|      17|      31|       5
---------------------------------------------------------------------------
   17-   31 (15.88/13.06)	PATSSDpslGSSGSV
   44-   55 (21.76/ 9.57)	PAHSVN...GSSSQI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20162 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GDIGSNGDSSKAPSAKPTAPNTPLISMPGAAMNRPKAQLLPGQNPARPQRSIKKRSYGDSSFEGYGEGFPDDDTGLETGYSTGEGEGGQKRRKKSSGTTPPYPSAMRQSSYGPGMVGV
2) MMSFHPQTPQSPSQFSPATSSDPSLGSSGSVVAAGSGTTTLPTPAHSVNGSSSQIEHMMLDDSPHKRKRPLEDVGDDREPKKAHVEDGKLAL
231
1
348
92










Molecular Recognition Features






MoRF SequenceStartStop




1) PYPSAMR
2) QKRRKKSS
331
319
337
326