<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20154

Description Uncharacterized protein
SequenceMTSRTPIGVHPRPPQRALSSSTLPPVQRPPPQQRALSQQLFPSSPIRKDSILSDASSDSFDPVQAQSHGANQAQAQGRLVATPRRVGSRLRLELSNIDPVVGSAASASLSASASASVSAASSPQSHATSRVPSMADAADVGDSSPAPSRASAADIDNDNQPLPMPKRRPPTSQTYPELSRRLAAPSRAAPALKKDGRPRPWTVEVPKGAPRYPSSEKRPNPTGGDPFSRGLFSGHADFFPWHGGNGKHHEDDWSPEAIQKGTWDRGNQNETSSARMTISPAIKQKSGLSALSTIFMGVLNQRRHRGHVTAPSTFKPPPRVTLTDTKREVWMKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKSVPTERAVWLAKCVGANEIRAFKRKGAPGGAFAIAGEFKWIRDWTVFVEQFIESVTSAFGEPDWKAKVTYAIRLATNLYAEQLLDRDHYLDWITSGLEHSPQSKIPMWILIAQICWADILRSRKYGRRLVYSILGHLHTIHVHPDKDILIQLSSQLSTLLASLIRNNPDSFIDPGLWPKYKDALEAFLPRDDKAGREAYHHVSVRNGQVSITSTASPAAGRPQLVRLLDATLLSQIDRDLPQKCWATGDDKVDIVRTTVDWATSFYRPGLARVYIAANLIKVWSTLRINVTATILEHMDTIPAGDGGRKQMVYHLVTELVRTGQFLVSQYLQWLVARGACSHPSEVDSDDAPCTTRLLIHLPIHYLTEDQKDDRANLLRRAANYSTAEEASDISNSLMCVNHTLGLPVEGDAMAGRRPIPLRKLLPRIISSSKALQTAVGLHLRETVLRLVKSVQPVSLRMFSAIRTILEATQDFYALCDVLKLCSRTTNIEVLASCVDTVNLHLQVFYAQGGAERLFTIFFERLKAINQEQGLVSRPLLAALCFLSRRMPSRQELSKYLAHELTQSDRNNATDACSPISDNMVNPPSGADGEVSEQIEKLLASGNSIDHPTMNRLFGYIIRRLEAGWAKMDDNRRVHASLLTRLRLFDAQHFDKLMSDWVGRVRLLKSRQRLDAVFPLLIITDALPVSFLELLHLVLSRLPADSDLSQEEAYRFGIYQRAIQLNHYKGLLSLIRHAAVEYADLRARVGNTKLPLDDDTYRESVLDALRLLVVVHTPDVTEAFSPKNIPPAGFRLVHEMISSLFQQEGHPPGAPLAASYDEILRLTNELTMPFCQIKLNMDLSISPPRPTEGEDGQQQPSPSPFDLFAKAMDRAIEAQNIMWTTMLPCLSEDISRHLQSQARSRFLDLVPTSSKEPSNLQNAAANSNNLYLAEKLLGVIEAIVVGQPPPNTAQLNSVVADRLSNLVEIVVAPKDHEDKTEGMLVPIIEHWLPMLLKFVLLHSVSLEPLSASVMTTSAQGKLVLPPHHEARAHTVLTLCRLFLALEALPSQLVGGSLLQQVFDVTTVLADGLPDDLRLHCAKSILLLPGMMPSLHTSSDARLHYILSVPQMASTDALMLAHREKTTTPHSTAARGMGAMYGIGPASQERLSPYVLRRWELLSEPTPNVGVNDTSLSLSLFEAIRIH
Length1549
PositionKinase
OrganismTrichoderma citrinoviride
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.226
Instability index50.91
Isoelectric point8.89
Molecular weight171276.01
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20154
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     133.82|      32|     128|       2|      42|       1
---------------------------------------------------------------------------
    2-   33 (63.22/24.73)	TSRTP.......IGVHPRPPQRALSSS.......TLP.PVQRPPPQQ
  128-  173 (41.45/12.14)	TSRVPsmadaadVGDSSPAPSRA.SAAdidndnqPLPmPKRRPPTSQ
 1133- 1154 (29.15/ 7.34)	..RLL.......VVVHTPDVTEAFS.............PKNIPP...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.98|      38|     204|     619|     704|       2
---------------------------------------------------------------------------
  318-  355 (65.60/23.07)	PRVTLTDTKREVWMKDLANPAISLRRLSRTIPHGIRGR
  635-  672 (64.38/99.40)	ARVYIAANLIKVWSTLRINVTATILEHMDTIPAGDGGR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.54|      40|     204|     180|     220|       3
---------------------------------------------------------------------------
  180-  220 (68.39/47.21)	RRLAAPSrAAPALKKDGR.PRPWTVEVPKGAPRYPSSEKRPN
  387-  427 (66.15/40.91)	KRKGAPG.GAFAIAGEFKwIRDWTVFVEQFIESVTSAFGEPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.72|      14|      91|     527|     540|       4
---------------------------------------------------------------------------
  527-  540 (27.36/18.54)	LIRNNPD...SFIDPGL
  618-  634 (21.36/12.65)	IVRTTVDwatSFYRPGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.92|      34|      91|     797|     850|       5
---------------------------------------------------------------------------
  797-  831 (50.16/23.90)	KALQTA.VGLHLRETVLRLVKSVQ...PVSLRMFSAiRT
 1353- 1375 (30.19/ 8.20)	..........HWLPMLLKFV.LLH...SVSLEPLSA..S
 1409- 1446 (44.58/42.89)	EALPSQlVGGSLLQQVFDVTTVLAdglPDDLRLHCA.KS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.04|      27|      91|    1005|    1039|       7
---------------------------------------------------------------------------
  880-  906 (43.64/21.92)	RLF.TIFFERLKA..INQEQGLVSRPLLAA
 1010- 1039 (36.40/41.13)	RLFdAQHFDKLMSdwVGRVRLLKSRQRLDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     244.79|      73|     539|     909|     989|       8
---------------------------------------------------------------------------
  909-  989 (119.81/103.36)	FLSRRMPSRQELSKYLAHELTQSDRNNATDACS.PISDNMVNPPSGAdgevseqiEKLLASGNSIDHPTMNRLFGYIIRRLE
 1449- 1522 (124.98/90.51)	LLPGMMPSLHTSSDARLHYILSVPQMASTDALMlAHREKTTTPHSTA........ARGMGAMYGIGPASQERLSPYVLRRWE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.31|      19|      91|     486|     515|       9
---------------------------------------------------------------------------
  490-  508 (35.71/39.11)	GRRLVYSILGHLHTIHVHP
 1156- 1174 (35.60/11.68)	GFRLVHEMISSLFQQEGHP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20154 with Med12 domain of Kingdom Fungi
Unable to open file!