<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20152

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTGEYETNTLLINNVSSIAYRLYEPVPSLSQNFASTALDIENSLREKGHVVLYDATKRGLWHFQFLPKDARLDDLGDGLELPPDVTGQGLAVKEHGVIEPPIIQKPRSQAPQSSITPTSLLSTSSILEQAHRPALSSPLQTTAPALQDQDPKAETKPKATTAQRTLYEKFIASVLSTLSTTFCRRTGAIPLNYRTVLLSPTTYNALPHAVAVGRPQILGTFRVYLTTTGAMMIGLALTKCRGILSLDDAVPSGLAPPGYSVLAAPFGIMTAAQSFLPGGDGSMSLAQTPMTQFFNFRGGVDGQESVWKQACLRFLNFRGIAASTLSGCLWVNLSVPKPKNPDSRGDHRFSSAHSSFTLPWPRRLCFRKKNVDVSSTSRVVDTVLSGHEESHDPLGNTKGWYTSLTEREERAKRAMERAANILKEQNQNTESKTPRPSGLSPAALQRPNTATAGIMYPTPPDGVHQLNGVTPSIDGTLSSPGNPLSAPVAAETDTIVQGEPPGGDSLDQPLEFAESKRQRSDSNLLGDTAPLAPVPMPASLPHHPPVPLPSTTAAQAATSALAPIPSLPPPPHTALPPPPPPPSQDRVVFAKPELKHARSQNEDQARRNRGDIRVTPAKRESSPFDPHAVFKRVKASLKIQKHDAKGSSQPTGRKAKIFESLDFDPALPLINKKYEQGGFFDPSALSKVEKMEKPNLDLRAVPETDYLKRHGKLNRKQRERPGTRSAMSKPYSALELQGSTGSPMKLDGSISEGEESSVESDQDDSSYTSDEPGSPHKASIRLINGDDDILSQITSLRDGDIEEPDHQLAMELPRLSKSDMSGAPLSLLFSDPEPLMLDMALNDDDMIQIAQIVTEQAATGGLDIFRASDFEPPTLSASQKRQELSTYGRDAFHTLEEVVGQFFGDAMPMRLKGLLDLQDMPLLSQFQPRQIPGREGNPEAMRPSNLYQIPSPHLEVQRADTKLSVLPSAVSFWESLGLSPSSGSKNINAICVFPGWPGMRDNVQTFLDRIKSVYEFLKLGSFDVMPLGADMEPGLLPYEVDRITTSPDATVTGHGSAMIESLETLRGLFTNLSITETNFVIYFVYSPDNPGTIIESCTAFQRFFETYQKILATRKEPPQNELVLQLVSADLLSSPTALVVTPTSDLVRLCIETYDRCTLFGGPMPAPAIRLEQLLPRIIDFKLTTNPSASLIRENSCIHVAYAQSVDERWITAAWTDDRGNQQATASYCLARKGKPPSRNMNDIAHEIWETTLELISAWKVLWRVIITKCGPMPQHEMDFWVDLARTEINAKVTVALLTVDTNPSLQLLPPVVRLPPPSAALHTPVSTPQANVLSPEQINTPATPAANVTAATPSGDGSASNANTAEADSDAILVDVTDQTWGAIAGHRLSNSTSILEVQPALISGYLIKRTGIRVEDAPVAMEVNLVYTEAMPRVHEPLFREMLGYFRGLGTLARARGVVDREADVRPWHVAAAEKAARALYLLM
Length1487
PositionKinase
OrganismTrichoderma citrinoviride
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.323
Instability index46.36
Isoelectric point5.74
Molecular weight161991.79
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20152
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.93|      18|      18|     282|     299|       1
---------------------------------------------------------------------------
  282-  299 (33.96/19.44)	GSMSLAQTPMTQFFNFRG
  303-  320 (32.97/18.67)	GQESVWKQACLRFLNFRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.41|      31|      31|     521|     551|       2
---------------------------------------------------------------------------
  475-  515 (30.90/ 7.93)	.DGTLSSPGNPLsAPVaaetdtivqgepPGGDSLDQ........PLEFAE
  521-  551 (60.30/22.03)	SDSNLLGDTAPL.APV............PMPASLPHHP......PVPLPS
  557-  584 (40.21/12.39)	AA......TSAL.API............P...SLPPPPhtalppPPPPPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.23|      24|      44|    1087|    1110|       3
---------------------------------------------------------------------------
 1047- 1068 (34.55/19.86)	SPD.....ATVTGHGSA.MIES.LETLRG
 1087- 1110 (43.80/27.39)	SPD...NPGTIIESCTA.FQRF.FETYQK
 1129- 1157 (22.89/10.36)	SADllsSPTALVVTPTSdLVRLcIETYDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.06|      32|     114|    1158|    1193|       4
---------------------------------------------------------------------------
 1158- 1193 (54.54/43.06)	CtlfgGPMPAPAIRLEQLLPRI.IDFKLT.......TNPSASLI
 1271- 1310 (51.53/30.67)	C....GPMPQHEMDFWVDLARTeINAKVTvalltvdTNPSLQLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.57|      18|      18|     219|     236|       7
---------------------------------------------------------------------------
  219-  236 (30.41/19.85)	LGTFRVYLTTTGAMMIGL
  238-  255 (30.16/19.62)	LTKCRGILSLDDAVPSGL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      88.78|      28|     612|      97|     150|       8
---------------------------------------------------------------------------
   97-  127 (41.51/14.58)	GVIEPPI......IQKPRSqapQSSITP.TSLLSTSSI
  439-  449 ( 8.64/10.45)	G.LSPAA......LQRPN....................
  679-  713 (38.63/ 7.14)	GFFDPSAlskvekMEKPNL...DLRAVPeTDYLKRHGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.13|      21|      30|     771|     797|       9
---------------------------------------------------------------------------
  742-  762 (34.40/15.27)	GSPMKLDGSISEGEE...SSVESD
  774-  797 (30.73/30.07)	GSPHKASIRLINGDDdilSQITSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.84|      17|      18|     128|     144|      10
---------------------------------------------------------------------------
  128-  144 (28.92/17.27)	LEQAHRPALSSPLQTTA
  147-  163 (28.91/17.26)	LQDQDPKAETKPKATTA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.74|      18|     104|     914|     933|      11
---------------------------------------------------------------------------
  914-  933 (29.09/22.41)	GLLDLqdMPLLSQFQPRQIP
 1021- 1038 (34.65/19.94)	GSFDV..MPLGADMEPGLLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.80|      24|     893|     450|     473|      20
---------------------------------------------------------------------------
  450-  473 (45.27/21.72)	TATAGIMYP....TPPDGVHQLNGVTPS
 1329- 1356 (36.53/16.13)	TPQANVLSPeqinTPATPAANVTAATPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20152 with Med13 domain of Kingdom Fungi
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