Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDTYIDSRFERLEKALATLIDSVTKYHPSPIQAEELKNADNELCKGLEQVEIHQKNHLKIQQLRQMSNALDAQIRETLTSLATTRKDLVTTQVTTYPSEPNYPFLYEELLGFARRISKTSMPPAAILNAMAGAPANQESQTPVPDAGPQASQAAMTPSAQTPSNPMQSPAPTNGVAEQQQTQASAHTSLPDNMNQFLNPLSGQLFFPWPLEDKIRSGALASNQILLEQGIDPRGYNPVAEEERKRREEEERKEREEREKQERAEREREAERQRQERQRAMEKQQAEWRRASTAAGVSGDAGVSGPPSAKAEKKQFQFTNLDDLDDDDDED |
Length | 330 |
Position | Middle |
Organism | Trichoderma citrinoviride |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma. |
Aromaticity | 0.05 |
Grand average of hydropathy | -0.991 |
Instability index | 52.71 |
Isoelectric point | 4.94 |
Molecular weight | 37085.55 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP20147 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 48.63| 15| 19| 240| 258| 1 --------------------------------------------------------------------------- 244- 258 (24.12/13.97) KRREEEERKEREERE 260- 274 (24.51/ 6.37) QERAEREREAERQRQ --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 86.10| 26| 43| 113| 139| 3 --------------------------------------------------------------------------- 113- 139 (39.82/26.04) ARRISKTSMPPAAiLNAMAGAPANQES 159- 184 (46.28/26.34) AQTPSNPMQSPAP.TNGVAEQQQTQAS --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 28.01| 10| 19| 201| 214| 4 --------------------------------------------------------------------------- 201- 214 (11.99/15.19) SGQLFFpwplEDKI 221- 230 (16.03/ 6.20) SNQILL....EQGI --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) PPSAKAEKKQFQFTNLDDLDDDDDED 2) QAEWRRASTAAGV 3) YPFLY | 305 284 102 | 330 296 106 |
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