<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20137

Description Uncharacterized protein
SequenceMTSRTPIGVHPRPPQRTLSSTTLPPVQRPPPQRALSQQLFPSSPVRKDSALSDASSDSFDPVQAQGQGQGQSANLAQGHGRLVTTPRRVGSRLRLELSNIDAPGSVASASMSASASASVSAASSPQSHTTSRGPSMADAVDVDGSSPAPSRASAADFDNDNHPLPMPRRRPPTSQTYPELSRRLAAPPRATPALKKDGRPRPWTVEVPKNAPRYPSADKKPNPAGGDPFSRGLFSGHADFFPWHGGNGKHHEDDWSPEAIQKGTWDRGNQNETSTARMTISPAIKQKTGLSALSTIFMGVLNQRRHRGHVTAPSTFKPPPRVTLTDTKREVWMKDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKSVPTERAVWLAKCVGANEIRAFKRKGAPGGAFAIAGEFKWIRDWTVFVEQFVESVASAFGEPDWKAKLTYAIRLATNLYAEQLLDRDHYLDWITSGLEHSPQSKIPMWILIAQICWADILRSRKYGRRLVYSLLAHLNTIHIHPDKDILMQLSSQLSSLLSSLLRNNPDSFIDPALWPKYREALDAFLPRDDKVGREAYHYINIRNGQLSFTSTASPLAGRPQLVRLLDATLLSQIDRDLPQKCWATGDDKVDIVRTTVDWATSFYRPGLARVYIAANLIRFWSTLRVNVTGAILEHMDTIPAGDGGRKQTVYQLVTELVRTGQFSVPQYLKWLMARGACSHPSEVDSDDAPCTTRLLVHLPLRYLTEEQKDDRANLLRRAANYSTAEEASDIGNALMCVNHTLGLPVQDDAMAGRNPIPLRKLLPRITSSSKALQTTVGLHLRETVLRLVKAVQPVSLRLFSAIRTILEGTQDFYALCDVLKLCSRTTNIEVLASCVDTVNLNLQVFYAQGGAERLFNIFFERLKAINQEQGLVSRPLLASLCFLSRRMPSRQEISKYLAHELAQSDRNNATDACSPISDNMVNPPSGADGEVSEQIEKLLASGNSIDHPTMNRLFGYIIRRLEAGWAKMDDNRRIHASLLTRLRLFDSQHFDKLMSDWVGRVRLLKSRKPLDAVFPLLIITDALPVSFLVGPASLTRAAAPGEADAAAPPDLATPGSVTYLQELLHLVISKLPADTDLSQEEAYRFGIYQRAIQFNHYKGLLSLIRHAVVEYADLRARDGNANLLLDDGTYRERVLDVLRLLIVVHTADVTEVFSAKTIPPAGFRLVHEIIGNLFQQEGDQGASSAAPYDQILRLANELTMPFCQIKLNMDLSIPAPRQTDGEDGRQQHPSQFDLFAKAMDRAIEAQNIMWTTMLPCLSEDISRHLQSQARSRFLDLVPTSSSSSKDPSILHDTLANSNNLYLAEKLLGVIEAIVVGQQPPNTAQLTSVLADRLSDLVEIVVAPKDQEDKMKGLLIPIIEHWLPMLLKFVLLHSVSLEPLSASVMTTTAQGKLVLPPHHEARAHTVLTLCRLFLALEALPSQIVGPSLLQQVFDVTTVLADGLPDDLRLHCAKSILLVPGMMPNLHSSSDARLFYIFSVPQLTATDGLMLAHREKTTMPHSTAARGMGAMYGIGPTTQERLSPFVLRRWELLSEPTPNVGVNDTSLSLGLFEAIRIH
Length1585
PositionKinase
OrganismTrichoderma harzianum CBS 226.95
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.227
Instability index47.63
Isoelectric point8.88
Molecular weight175188.32
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20137
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     270.86|     108|     142|       8|     148|       1
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    6-  137 (154.02/118.01)	PIGV...........HPRP.PQRTlssttlPPVQRPPPQraLSQQLfpSSPVRKDSAL.SD..........................ASSDSFdpvqAQGQGQGQsANLAQGHG.............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................rLVTTP.........RRVGSrlRLELSNIDApgsvasASMSASASASVSAASSPQSHTTSRGPSMA
  147-  245 (65.14/34.74)	PAPSrasaadfdndnHPLPmPRRR......PPTSQTYPE..LSRRL..AAPPRATPALkKDgrprpwtvevpknaprypsadkkpnpAGGDPF....SRGLFSGH.ADFFPWHG...............................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  900-  956 (51.71/14.96)	..................................................................................................................gngkhheddwspeaiqkgtwdrgnqnetstarmtispaikqktglsalstifmgvlnqrrhrghvtapstfkppprvtltdtkrevwmkdlanpaislrrlsrtiphgirgrtlldqclnksvpteravwlakcvganeirafkrkgapggafaiagefkwirdwtvfveqfvesvasafgepdwkakltyairlatnlyaeqlldrdhyldwitsglehspqskipmwiliaqicwadilrsrkygrrlvysllahlntihihpdkdilmqlssqlssllssllrnnpdsfidpalwpkyrealdaflprddkvgreayhyinirngqlsftstasplagrpqlvrlldatllsqidrdlpqkcwatgddkvdivrttvdwatsfyrpglarvyiaanlirfwstlrvnvtgailehmdtipagdggrkqtvyqlvtelvrtgqfsvpqylkwlmargacshpsevdsddapcttrllvhlplrylteeqkddranllrraanystaeeasdignalmcvnhtlglpvqddamagrnpiplrkllpritssskalqttvglhlretvlrlvkavqpvslrlfsairtilegtqdfyalcdvlklcsrttnievlascvdtvnlnlqvfyaqggaerlfnifferlkainqeqgLVSRPllaslcflsRRMPS..RQEISKYLA......HELAQSDRNNATDACSPISDNMVNPPSGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     367.06|     129|     144|     986|    1122|       2
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  435-  477 (29.02/ 9.13)	TYAIRLATNLYAE.QLLDRDHY....LDWItsGLEHSPQSKIPM....WILI...........................................................................................................................
  998- 1143 (192.12/132.62)	DDNRRIHASLLTRlRLFDSQHFdkLMSDWV..GRVRLLKSRKPLDaVFPLLIITDALPVS..F...LVGPAS..........LTRAAAPGEADAAAPPD....LATPGSVTYLQELLHLVISkLPA....D.TDLSQEEAYRFGIYQRAIqfnhykgllsliRHAVVE...YADL
 1144- 1282 (145.91/83.55)	.RARDGNANL..............LLDDGT..YRERV......LD.VLRLLIVVHTADVTevFsakTIPPAGfrlvheiignLFQQEGDQGASSAAPYDqilrLANELTMPFCQIKLNMDLS.IPAprqtDgEDGRQQHPSQFDLFAKAM...........dRAIEAQnimWTTM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.37|      32|     126|     573|     629|       3
---------------------------------------------------------------------------
  573-  605 (47.24/18.14)	GQLSFTSTASPlAGRPQLVRLLDATLLSQIDRD
  704-  735 (56.13/12.47)	GACSHPSEVDS.DDAPCTTRLLVHLPLRYLTEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     194.05|      61|     481|     337|     400|       4
---------------------------------------------------------------------------
  337-  400 (104.46/75.90)	ANPAISLRRLS..RTIPHGIRGRTLLDQCLNKSVPTERAVWLAKCVGA.N.EIRAFKrkgAPGGA...FAI
  819-  886 (89.59/57.20)	AVQPVSLRLFSaiRTILEGTQDFYALCDVLKLCSRTTNIEVLASCVDTvNlNLQVFY...AQGGAerlFNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.53|      22|     204|     201|     222|       5
---------------------------------------------------------------------------
  201-  222 (42.65/23.19)	RPWTVEVPKNAPRYPSADKKPN
  408-  429 (39.88/21.25)	RDWTVFVEQFVESVASAFGEPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.44|      28|     696|     759|     800|       9
---------------------------------------------------------------------------
  771-  800 (45.07/49.94)	GLPvqDD..AMAGRNPIPLRKLLPRITSSSKA
 1470- 1499 (47.37/21.05)	GLP..DDlrLHCAKSILLVPGMMPNLHSSSDA
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20137 with Med12 domain of Kingdom Fungi
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