<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20132

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTGEYETNTLLINNVSSIAYRLYEPSSNLSQNFASVALEIENSLREKGHIVLYDATKKALWHFQFLPKDENSDDLGDSLELPPDVTGHGLALREHGVIEPPIIQKPRSQGLQSSGTPTSLLSTASALEQAHRPTLSSPLQTTAPITQDPDPKAEKSKTTSTAQRALYEKFIASVLLTISTTFCRRVGAVPLNYRTVILSPTAYDAQPHGVAIGRPQILGTFRAYLTTTGALMISLALTKCRGILSLDDTVPSSLAPSGYSVLAAPFGIMTATQNFVPGDGGLTSLAQTPMTQFFNFRGGLDGQESLWKQACLRFLNFRGIAASTLGGCLWVNLLVPKPKNPDTRGDQRSSSASSSFTLPWPRRLCFRKKNVDASSTSRVVDTVLSGHEESHDPLGNAKGWHASITEREEKAKRALERAANLPKDPQPQNTESKTTPKPSGLSPVALQRPNTATAGIMYPTPPDGVHQPNGVTPSIDGTLSSPGNPLSVPVIAEADAAVQNEPTGGDSVDQSPEFSDSKRHRSDSNVLGDGETVFGGEIGGDMFDDNDITEADFNFFDEKPDDMDADLPMADISSSEMALPPPPEAVEETVIPVETTPLPLAPTPTSLPLHPPATPSAPTPAQAATPAPAPAPIPSLPPPTSTPLLPPPLPPPQSERVVFAKPELKHARSQNEDPARRSRGEIRVTPAKRESSPFDPHAVFKRVKASLKMPKYDSTTSSQPTLRKAKIFESLDFDPALPMINKKYEQGGLFDLSALSKVEKMERPSIDLRAVPETDYLKRHGKLSKRQRDRPITRSTMAKQYSALEPQMSTTSPMKLDGSISGEDSSAESDQDDSSYTSDEPGSPHKASIRILNADDDILSQITSLRDCDIEEPDHQLAMELPRLSKSDMTGVPLSALFSDPEPLLLDMALNDDDLIQIAQIVTEQAATGGLDIFRASDFEAPTLSASQKRQELLTHSRDAFHTLEDIIAQFFGDTMPMRLKGLLDIQDIPLLSQFQPRQIPGREGNPEAMRPSNLYQIPSPHLEVQRADTKLSVLPSAVSFWESLGLSPSSGSKNINAICVYPGWPGMGDNVQTFLDRIKSVYEFLKLGTFEVMPLGADMEAGLLPYEIDRITTSPDATVTGHGSAMIESMEVLRGIFTNLATTETNFVIYFVYSPDNPGTIIESCTAFQRFFETYQKILATRKEPPQNELVLQLVSADLLSSPSALVVTPTSDLVRLCIETYDRCTLFGGPMPAPAIRLEQLLPRIIDFKLTTNPSASLIRENSCIHVAYAQSVDERWITAAWTDDRGNQQATASYCMGRKGKQPSRNMNEIANEIWETTLELISAWKVLWRVIITKCGPMPQHEMDFWVDLARTEINAKVTVALLTVDTNPSLQLLPPVVKLAPPSAALHTPASTPLPSAFSPEPPTPATPAREGMAVATPSGDGGASNAGAADADLDAILTDVTDQTWGAIAGHRLSNSTSILEVHPALISGYLIKRTGIKVEDAPIVMEVNLVYTEAMPRVHEPLFREMLGYFRGLGTLARARGVVDREADVRPWHVAAAEKAARALYLLM
Length1556
PositionKinase
OrganismTrichoderma harzianum CBS 226.95
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.309
Instability index48.57
Isoelectric point5.14
Molecular weight169093.42
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20132
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.48|      14|      20|     612|     631|       1
---------------------------------------------------------------------------
  612-  629 (19.87/10.36)	PPaTPSAPTpaqAATPAP
 1398- 1411 (26.61/ 9.06)	TP.LPSAFS...PEPPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      91.23|      18|      20|     282|     299|       2
---------------------------------------------------------------------------
  259-  278 (23.05/11.89)	GYSVLA.APfgiMTATQNFVP
  282-  299 (35.63/22.55)	GLTSLAQTP...MTQFFNFRG
  303-  320 (32.55/19.94)	GQESLWKQA...CLRFLNFRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     184.62|      39|      55|     631|     669|       3
---------------------------------------------------------------------------
  469-  522 (37.68/13.77)	PNGVtPSID..GTLSSPGNPLSVPvIAEADAAVQNEPTGgdsvdqspefsdsKRHR
  565-  592 (30.01/ 9.24)	DADL.PMAD..ISSSEMALPPP.P.EAVEETVI.......................
  631-  669 (70.98/33.43)	PAPI.PSLP..PPTSTPLLPPPLP.PPQSERVVFAKPEL.............KHAR
  687-  727 (45.94/18.64)	PAKR.ESSPfdPHAVFKRVKASLK.MPKYDSTTSSQPTL.............RKAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     155.46|      43|      47|     877|     921|       4
---------------------------------------------------------------------------
  839-  865 (26.49/ 9.52)	...........SDEPGSPHKAsiriLNAD...............DDILSQITS
  877-  921 (70.94/45.68)	QLAMELPRlsKSDMTGVPLSA....LFSDPEPLLL....DMALNDDDLIQIAQ
  929-  971 (58.04/31.50)	TGGLDIFR..ASDFEAPTLSA......SQKRQELLthsrDAFHTLEDI..IAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     243.30|     116|     257|      61|     211|       6
---------------------------------------------------------------------------
   61-  124 (60.25/41.41)	.................................................................................................................................................................................................................LWHFQFLPKDENSDDLGD........SLELP.PdvtgHGLALREHGVIEPP...IIQKPRSqGLQSSGTPtslLST
  125-  211 (56.29/69.70)	ASALEQAHRPtlSSPLQTTAPITQDPDPKAEKSKTTSTAqralyekfiasvlltisttfcRRVGAVPL...NYRTV.ILSPTAydaqPHGV..................................................................................................................................................................................................
  330-  397 (56.89/20.26)	...........................................................................................aigrpqilgtfrayltttgalmislaltkcrgilslddtvpsslapsgysvlaapfgimtatqnfvpgdggltslaqtpmtqffnfrggldgqeslwkqaclrflnfrgiaastlggcLWVNLLVPKPKNPDTRGDqrsssassSFTLPwP....RRLCFRKKNVDASStsrVVDTVLS.GHEESHDP...LGN
  403-  466 (69.86/33.13)	ASITEREEKA..KRALERAANLPKDPQPQNTESKTTPKP.....................SGLSPVALqrpNTATAgIMYPTP....PDGV..................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.36|      15|      20|       6|      20|       7
---------------------------------------------------------------------------
    6-   20 (25.05/13.89)	YETNTLLINNVSSIA
   24-   38 (26.31/14.91)	YEPSSNLSQNFASVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.58|      20|      20|     524|     543|       8
---------------------------------------------------------------------------
  524-  543 (35.60/22.27)	DSNVLGDGETVFGGEIGGDM
  545-  564 (36.98/23.43)	DDNDITEADFNFFDEKPDDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.96|      21|     257|     972|     992|       9
---------------------------------------------------------------------------
  972-  992 (41.07/23.34)	FFGDTMP...MRLKGLLD.IQDIPL
 1229- 1253 (30.90/15.71)	LFGGPMPapaIRLEQLLPrIIDFKL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20132 with Med13 domain of Kingdom Fungi
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