<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20127
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MYELFLTALVEDSDINTALAVLSGFCSMQPWESVSRVIYFQGPPRPSGITNQRSFEKPIRKEAALLWKELHQNLSRQSFVLQARYEIYKDRDLGPSAEPVDLDTVSGILRWTDFPDPPRNQPILTQRKKVELWEQRKLLSVLRENNHQYKTETVEEMYRFFRDDVEFCLTRHYFVGPLEDYVPLAAKSAPPTEPKPTLPAWDSLTRVDSQNRWILQVKAHVVQDNKPDEIKKAQDQLLKFRTDLEGVFEFKVIDRKVHDTRVVMQQQGVQVLPQKVLLGKS |
Length | 281 |
Position | Head |
Organism | Trichoderma harzianum CBS 226.95 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.542 |
Instability index | 42.91 |
Isoelectric point | 6.98 |
Molecular weight | 32767.07 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP20127
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 256.65| 59| 73| 32| 90| 1
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32- 90 (100.38/47.94) ESVSRVIY...FQGPPRPSGITNQRS....FEKPIRKEAAL.LWKELHQNLSRQSFVLQARYEIYKD
103- 163 (77.76/35.92) DTVSGILRwtdFPDPPRNQPILTQRKkvelWEQ..RKLLSV.LRENNHQ...YKTETVEEMYRFFRD
169- 224 (78.51/36.32) ..LTR.HY...FVGPLEDYVPLAAKS.....APPTEPKPTLpAWDSLTRVDSQNRWILQVKAHVVQD
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