<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20119

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNDLPDEIIHITQGFIPISLLLTRLAQSTHNMIQDKIAELAKMPISTAATNGSANYTQSAPDDTSMENLKKKGVLLNFIQDMHSKWVKALVITEWSRKASSVSKLIDLKFHIDQQRLLYDAALDSIINVKRDLTYARMPSPDLKTALQILATGKAPWMPDLQYIELPPLTLEEQLRGIGDLDTLLSLRLNLDDFDKIPYQFQNYTIGSGRVTFKVAGEFEVDLTIADEDFEKQFWFIDFRFAFRPATLSLPDTLRTFLENCVNEALAKDGLAGCYQFLHEFVLTAKINELKRQALQLNRTSWSGTLAVEPLNRALAIQYWTSRSTATGVKNWIIVAVSSGRKPGGRPDPKATSSLVVKWYRDNKEVKDVEIKVDVENLSAESLLNDIVGRHIEFILSSIHSRLLATPRFKNRDTGVMLNISRVDPVASCLALQVGYGGTVSLLVEPISGAFAMKPHSKFSMQPELQLNNSKNPLDDGVNFLEHLRCAIIEDELGRMGTARGWSVRKAPVNVDELRSITKMRKWSRTLWIQHGGWGSAWFVVVILSLDGDEWWLLETDPTNSLPNSNGASKFSTRLPLNKGAPQVSGIFWDNLNTFAAGIIAQSVDMRELRRLKIKSQSSGSADLSLPQQVRIPSIEVALSTIFPSMMQETAEDMSSQGHGGVVEPNEDLQILALIRPTSGSTSSTKQPWAEDMMAIRFKGVHAVASHREIDEGYTTSHDLVCTSEAVIRVRRPAKFLALKGMVDRDVSYDPKRGEFVLQIPRPVTQPIFDILKSRVKAIDRFVNFLEAMEKAKGSIIGESITLKAVVFCYSAPPSTQPKDESAALISSPERWRVKMDLSNEDIDIHIEKGNPHLRVIDLARNLASTEGGIGSLMAWLPVSLPALKAIDQLDAEWDELSKKGQGRLNFSMKSLTWMNLKYNIFGVSSTGEKTKKTICLDVRIRLRRGQVWWHAWRSDPDAAADDEISKALKTVWDGKGSNWLGLATGAAAEANDGVMDMLLAIDKAIRGAITTSPQRET
Length1018
PositionTail
OrganismTrichoderma asperellum CBS 433.97
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.07
Grand average of hydropathy-0.207
Instability index38.88
Isoelectric point6.82
Molecular weight113448.75
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20119
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     150.25|      41|     108|     465|     505|       1
---------------------------------------------------------------------------
  465-  503 (63.47/42.55)	....LQLNNSKNPLDDGVNFLEHLRC.A...IIE.DELGR......................MGTARGWS
  504-  524 (22.62/10.20)	VR........................kA...PVNvDELRS......................ITKMRKWS
  779-  833 (20.83/ 8.79)	.............IDRFVNFLEAMEK.AkgsIIG.ESITLkavvfcysappstqpkdesaalISSPERWR
  834-  876 (43.33/26.60)	VKmdLSNEDIDIHIEKG.N..PHLRV.I...DLA.RNLAS..................teggIGSLMAW.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.06|      32|     302|     422|     463|       2
---------------------------------------------------------------------------
  422-  455 (52.72/46.83)	RVDPVASCLALQVGYGGTVSLlvEPISGAFAMK.P
  729-  761 (53.34/25.45)	RVRRPAKFLALKGMVDRDVSY..DPKRGEFVLQiP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.55|      17|      42|     616|     633|       3
---------------------------------------------------------------------------
  616-  633 (25.82/20.56)	SQSSG.....SADLSLPQQVRiP
  656-  677 (24.73/14.34)	SQGHGgvvepNEDLQILALIR.P
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     122.55|      38|     302|     575|     615|       4
---------------------------------------------------------------------------
  575-  615 (56.36/46.30)	LPLNKGAPQVSGiFWDNLNTFAAGIIaqSVDMRELRRLKIK
  881-  918 (66.19/43.01)	LPALKAIDQLDA.EWDELSKKGQGRL..NFSMKSLTWMNLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.15|      13|      38|     640|     654|       8
---------------------------------------------------------------------------
  640-  654 (20.87/17.27)	STifPSMMQETAEDM
  681-  693 (26.28/14.52)	ST..SSTKQPWAEDM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20119 with Med14 domain of Kingdom Fungi
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