<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20114

Description Uncharacterized protein
SequenceMTSRTPIGVHPRPPQRTISSSTLPPAQRPPPQRALSQQLFPSSPVRKDSALSDASSDSIDHAQAQMHGQGTNQAQNHGRLVTTPRRAGSRLRLELSNIDQAMLSATASATASAPVSAASSPQSHTTSRVPSMADAGDVGDSSPTPTRASAADLDHDNHPLPMPKRRLPASQTYSKLSKRLEPPPRPTPTFKKDGRPKPWTVEVPKDAPRYPPAEKRPGATGGDPFSRGLYSGYADFFPWHGTNNIKHHEDDWSYEAIQKGTWDRGSQNETGTARMTISPAIKQKTGLGALSTIFMGILNQRRHRGHVTAPSTFKPPPRVTLTDTKREVWMRDLANPAISLRRLSRTIPHGIRGRTLLDQCLNKSVPTERAVWLAKCVGANEIRAFKRKGAPGGGAFAIAGEFKWVRDWTVFVEQFIESVTFSFGEPDWKAKVTYAIRLATSFYAEQLLDRDHYLDWITSGLEHSSQSKLPMWILIAQICWADILRSRKYGRRLVYALLDHLNTIYIHPDKDILIQLSSQLSTLLASLVRDKSDSFIDPSLWPKYRDALEAFLPRDDKAGRDAYHHINARNSQVAITSNTSPLAGRPQLVRLLDATLLSQIGRDLPQKCWATGDDKTDIVKTTVDWATSFYRPGLARVYIAANLIKVWASLRIDVTGAILEHMDTIPAEDEGRKQMTYHLVAELVRTGQFSVTQYIKWLMARGGCSHPSEVDSDEAPCTTRLLVHLPVHYLTEDQKDDRSSLLRRAASYSVVEEANDIHNALMCVSHTLGLPLQDDEMSGRKPIPLRKLLPMIINSSRALRCAVGVHLRESVMRLNKSVQAMSQRLFSAIRTILEATQDFYALCEILKFCSRTTNIEVLASCVDTLNLNLQVFYAQGTAERLFTVFFERLKAINQEQGLVSRPLLASLCSLSRRMPSRQDLSKYLAHELTQSDRNNATDACSPISDNNMVNPLSGADGEVSEQIEKLLASGNSIDHPTMNRLFAYIIRRLELGWTKMDDNRRIHASLLTRLRLFDAQHFDKLMSDWVGRVRLMKKRERLHAVFPLLIITDALPISFLFGPTSLIQAPAPQGDADSAAAAAAPLLNLISPGAATFLQELLHLILSKLPDDTDLSQEEVYRFGIYQQSIHFSHHKGLLSLIRHAIIEYAELRAGDGNAKLPLDDATYRSNLLDALQLLVVLHTADVTEAFSVKSIPPGGFRLVHDIISNLFKQSGTEDGSSLATPYDEILRQTNELTMPFCQIKLNMDLSVSPPRQTESEDAPQSVSQYDLFAQAMDRAIGAQNVMWTTMLPCLSKDISRHLQSQARQRFLALVPASSQLKDPLGNLQGALSSNNNLYLAEKLLGVIEAIVVGQQPPATAQLTMALANKLSDLVDLVVAPRAAEDKKEGVLTSVIEHWIPMLLRFVLLHSVSQEPLSASVMTTSVQGKLLMPPHHEARAHTVLTLCRLLLGLEALPSQVAGGGLLQQVFDVAAVLADGLPDDLRLHCAKSVLVVPGMMPSLHTSSDSRLYYIFSIPPPTAMDGMMLAHREKAAVPHSSASRGMGAMYGIRPLPHERLSPYVIRRWEMLSEPTPNVGVNDTSLNLSLFEAIRIH
Length1590
PositionKinase
OrganismTrichoderma asperellum CBS 433.97
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.239
Instability index48.87
Isoelectric point8.79
Molecular weight176200.67
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20114
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.79|      60|     317|    1133|    1201|       1
---------------------------------------------------------------------------
 1133- 1201 (84.27/88.20)	GLLslirHAIIEYAELRAgDGnakLPlDDAT..YRSNLLDALQLLVVLHTADVTEAFSVKSIPP....GGFRLVH
 1460- 1525 (98.53/71.24)	GLL....QQVFDVAAVLA.DG...LP.DDLRlhCAKSVLVVPGMMPSLHTSSDSRLYYIFSIPPptamDGMMLAH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.11|      28|     130|     180|     220|       2
---------------------------------------------------------------------------
  180-  207 (55.64/19.98)	LEPP..PRPTPT.................FKKDGRPKPWTVEVPKDA
  313-  337 (44.50/13.55)	FKPP..PRVTLT....................DTKREVWMRDLANPA
  356-  391 ( 3.96/ 8.61)	LLDQclNKSVPTeravwlakcvganeiraFKRKGAP...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.42|      10|      95|     763|     773|       3
---------------------------------------------------------------------------
  763-  773 (15.67/12.53)	CVShTLGLPLQ
  861-  870 (19.75/10.11)	CVD.TLNLNLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.82|      22|     134|     930|     955|       4
---------------------------------------------------------------------------
  930-  955 (32.20/28.72)	QSDRNNATDACSPISdnNMVNPlsGA
 1069- 1090 (37.62/20.41)	QGDADSAAAAAAPLL..NLISP..GA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     153.22|      40|     134|     469|     520|       5
---------------------------------------------------------------------------
  469-  515 (65.52/58.56)	LPmwiliaQICWA......DILRSRKYGRRLVYALLDHLNTIYIHPDKDiLIQ
  604-  645 (57.96/32.90)	LP......QKCWAtgddktDIVKTTVDWATSFYR..PGLARVYIAAN...LIK
  647-  669 (29.74/11.45)	...........WA......S.LRIDVTG.....AILEHMDTI...PAED....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     204.00|      61|     192|      24|      84|       6
---------------------------------------------------------------------------
   24-   84 (106.81/68.34)	PPAQRPPPQ...RALSQQLFPS....SPVRKDSALSDASSD.SIDHAQAQMHGQGTNQAQNHGRLVTTP
  211-  279 (97.19/61.40)	PPAEKRPGAtggDPFSRGLYSGyadfFPWHGTNNIKHHEDDwSYEAIQKGTWDRGSQNETGTARMTISP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.23|      14|      57|    1349|    1367|       8
---------------------------------------------------------------------------
 1312- 1328 (20.08/ 8.22)	PASSQLKDPLGNlqgAL
 1354- 1367 (24.15/ 8.29)	PATAQLTMALAN...KL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.25|      35|     570|     979|    1015|      12
---------------------------------------------------------------------------
  979- 1015 (53.26/46.02)	NRLFAYIIRRLELgWTKMDDNRRIHASLLtRLRLFDA
 1552- 1586 (62.98/43.56)	ERLSPYVIRRWEM.LSEPTPNVGVNDTSL.NLSLFEA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20114 with Med12 domain of Kingdom Fungi
Unable to open file!