<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20113

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMETGEYETNTLSINSVSSITYRLYEPSPNLSQNFASVALEIENSLRDRGYIVLYDAARRGLWHFLFLTKDEEENLDKVGDSLRLPFDVLEQGLVVKEEGIIEPPIMPKPRSQALQSGNTPTSLLSTNSTLEQAHRPALSSPLQTTTPSSQDHELKAESRTKTTAQSLLYEKLITAVSLTISTAFCRRTGAIPLNYRTILMSPTAYSAQPHGIAIGRPQILGTFRVYLTTTGALVVGISLTKCKGILSLDDTAASSLAPSGYSVLAAPFGIMTATQNFVPGDGGMSSLAQTPMTHFFSFRNGLDGQESLWKQACQRFLDFRGIAASTLGGCLWVNLLVPKSKSVDSKGDHRSSGAHSSFTLPWPRRLCFRKKNVDASSTSRVVDTVLSGHEESHDPLGNAKGWHSSITEREERIKRVMERTATMPKDSHPQPADSKTPKLSGLSPVALQRPNTATAGIMYPTPPDGIQQPNGVTPSMDGTFSSPGNPLSAQIMPEADVTIQNEPAGGDGLDQSPNVAEPKRRRSDNNLLGDTDNMLGGDVGGDMFDDNDITEADFNFFDEKPGDLDVDMAMSDLPSSEMAPSQAAEEPIRPVETMQQPLAPTPMSLPPAPSLPPSTPTPVPAVSPTSAPAPALPAATSLPPPPQPPPPQKETVVFAKPELKHARSQNEDAARRNRDIRVTPAKRESSPFDPHAVFKRVKASLKIPKYDSSISSQHPWRKAKVFESLDFDPAIPMISKKYEQGGFFDLSGLSKVERMEKANGDVRAVPETDYLKRHGKLNRKPRDRSTARHAGGKQYFALEPQILTTSPMKLDGSISDREDGNIESDQDDSSYTSDEPGSPHKASIRLIHGDDDILSQITSLRDCDIEEPDHQLAMELPRLSKSDISGVPLSQLFLDPEPLLLDMGLTDEDVIQIAQIVTEQAATGSLDIFNASDFEPATLSASEKRSDLSIHARDAFYTLEGIIMHFFEDAMPVRLKGLLDIQDLPILSQFIPRHITGREGNSEAMRPSNLYQIPSPHLEVQRADTKLSVLPSAVPFWESLGLSPSSGSKNINAICVFPGWSGMGDNVKAFLDRVKSVYELLKLGTFEVMPLGEDVEAGLLPYEVDRITTSPDATVTRHGSAMVECMEALRGVFNSLTITETNFVIYFVYSPENPGTIIESCTAFQRFYESYQKILASRKEPPQNELVLQLVSTDLLSSPSALVITQTSDLVRLCIETYDRCTLFGGPMPAPAIRLEQLLPRIIDFKLTTNPSASLIRENSCIHVAYSQSVDERWVTAAWTDDRGNQQATAAYCMGRKGKPPSRNMTEIANEIWETTLELISSWNVLWRVIITKCGPMPQHEVDFWVDLARTEIHAKVTLVLLTVDSSPSLQLLPPAIKLPAPTAALHTPVSTPQPSMQSPEPVATPATPAANATAATPSNDGAAAGAGDADSDDILVDATDQTWGAIASHRLSNSTSILEVQLSLMSGYLIKRTGLRLEDPPIVMEVNLIYTEATPRVHEPLLREMLGYFRGLGTLARARGVVDKEGDVRPWHVAAAEKAVRALYLLM
Length1548
PositionKinase
OrganismTrichoderma asperellum CBS 433.97
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.318
Instability index53.74
Isoelectric point5.22
Molecular weight169017.30
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20113
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     187.64|      32|      32|     429|     460|       1
---------------------------------------------------------------------------
  429-  460 (54.57/22.21)	P....QP......A.DSKTPKL..SGLSPV....ALQRP.NTATAGIMYP
  463-  493 (37.14/12.64)	PdgiqQP........NGVTPSM..DG........TFSSPgNPLSAQIM.P
  574-  607 (38.53/13.40)	......P......S.SEMAPSQ..AAEEPIrpveTMQQP.LAPTPMSLPP
  608-  633 (27.44/ 7.31)	..................APSLppSTPTPV....PAVSP.TSAPAPAL.P
 1380- 1411 (29.97/ 8.70)	P....APtaalhtPvSTPQPSM..QSPEPV....A..TP.ATPAA.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.30|      27|      29|     318|     344|       2
---------------------------------------------------------------------------
  298-  314 (19.74/ 7.30)	.FRnGLDGQ...ESLW.......KQACQ
  318-  344 (46.49/27.70)	DFR.GIAASTLGGCLWVNLLVPKSKSVD
  348-  374 (49.07/29.67)	DHR.SSGAHSSFTLPWPRRLCFRKKNVD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.33|      21|      31|     687|     707|       3
---------------------------------------------------------------------------
  687-  707 (38.32/28.34)	PFDPHAVFKRVKASLKIP....KYD
  715-  739 (34.01/24.14)	PWRKAKVFESLDFDPAIPmiskKYE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.92|      54|     765|      68|     124|       4
---------------------------------------------------------------------------
   68-  124 (85.26/58.42)	TKDEEENLDKVgdSLRLPF...DVLEQGLVVKEEGIIEPP...IMPKPR.SQALQSGnTPTSLL
  832-  892 (81.66/45.98)	TSDEPGSPHKA..SIRLIHgddDILSQITSLRDCDIEEPDhqlAMELPRlSKSDISG.VPLSQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.60|      20|     765|     742|     763|       5
---------------------------------------------------------------------------
  742-  763 (28.50/30.43)	GFFDLSGlsKVERMEKANGDVR
  769-  788 (34.10/27.85)	DYLKRHG..KLNRKPRDRSTAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.25|      17|      18|     132|     148|       6
---------------------------------------------------------------------------
  132-  148 (30.12/18.00)	QAHRPALSSPLQTTTPS
  150-  166 (28.13/16.28)	QDHELKAESRTKTTAQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.84|      20|      20|     524|     543|       7
---------------------------------------------------------------------------
  524-  543 (38.61/22.29)	DNNLLGDTD.NMLG...GDVGGDM
  545-  568 (27.23/13.70)	DDNDITEADfNFFDekpGDLDVDM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     288.65|      89|     380|    1041|    1131|       8
---------------------------------------------------------------------------
 1041- 1131 (148.04/94.78)	GLSPSSGSKNINAICVFPGWSGMGDNVKAFLDRVKSVYEL.LKLGT.FEVMPLGEDVEAGLLPYEVDRITTspDATVTRHGSAMVECMEALRG
 1422- 1512 (140.61/84.01)	GAAAGAGDADSDDILVDATDQTWGAIASHRLSNSTSILEVqLSLMSgYLIKRTGLRLEDPPIVMEVNLIYT..EATPRVHEPLLREMLGYFRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.98|      15|      18|     179|     193|      11
---------------------------------------------------------------------------
  179-  193 (26.94/17.87)	TI...STAFCRRTGAIPL
  197-  214 (22.04/13.10)	TIlmsPTAYSAQPHGIAI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.92|      12|      32|      14|      25|      12
---------------------------------------------------------------------------
   14-   25 (21.15/14.69)	NSVSSITY.RLYE
   43-   55 (17.77/11.05)	NSLRDRGYiVLYD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20113 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MEKANGDVRAVPETDYLKRHGKLNRKPRDRSTARHAG
2) PMKLDGSISDREDGNIESDQDDSSYTSDEPGSPHKASIRL
3) SRVVDTVLSGHEESHDPLGNAKGWHSSITEREERIKRVMERTATMPKDSHPQPADSKTPKLSGLSPVALQRPNTATAGIMYPTPPDGIQQPNGVTPSMDGTFSSPGNPLSAQIMPEADVTIQNEPAGGDGLDQSPNVAEPKRRRSDNNLLGDTDNMLGGDVGGDMFDDNDITEADFNFFDEKPGDLDVDMAMSDLPSSEMAPSQAAEEPIRPVETMQQPLAPTPMSLPPAPSLPPSTPTPVPAVSPTSAPAPALPAATSLPPPPQPPPPQKETVVFAKPELKHARSQNEDAARRNRDIRVTPAKRESSPFDPHAVF
4) TAALHTPVSTPQPSMQSPEPVATPATPAANATAATPSNDGAAAGAGDADS
755
807
379
1383
791
846
694
1432










Molecular Recognition Features






MoRF SequenceStartStop




1) ITEADFNFFDEK
2) PHAVFKRVKASLKIPKYDS
3) VVFAKPEL
549
690
652
560
708
659