<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20110

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSSEGGPPLSLRPFPVADQKPKNLAEFIARVNAQPGGFRSITEDKLREELRNSEDPEAATDQDEEMSEAAGEADIAEKDPNVARMEVLKNIDIAGNAALLTLDSMSLLLSKQNPTQAGLTLSQQLRDMVGIGTLGADKLNDSNATPTKTKDQEATAMGWTLMEINKTRDSAEEAASFLEKEINSESKYWEDIVGVKKAGWSISRVPQERHTLGVRFGFSEAAAEFKNNGLAPMWRGHDGSADLDFGRLGGVSEALVVTYEKDGKVIGRSTTRPSSDDESLEARVLEARNTIFSQELWHELTKESRSLAAYDVKPEGRKLACQIDERTKITLELLPLESCPSPEQDMPENGLAEKISMALHILLSYAHRYNELMRIRPIPPHISRSSRQQSYALLRPVLARTMYLKNVEESMQYIGLLVRTLQKAGIQSSFILRTTQTNASDPNSRGPNQLSTSHTLVRNLLQTQDFTIELTILPDISLTIRGRSFSFPVTATYYYILLPPSSPLPAMCPPWSEGYPSVQALGDYLRTAIVCILTNHFVKMLSSPSSTSGDGSALVESAQGADKKNFDIHFALELGDDVEELTLSVNNAAQSEEETKIWKWSVNGPSETTSAEQVVKTLIEEQAPI
Length625
PositionHead
OrganismTrichoderma asperellum CBS 433.97
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.06
Grand average of hydropathy-0.414
Instability index57.14
Isoelectric point4.99
Molecular weight68915.81
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20110
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     374.29|     119|     163|     258|     383|       1
---------------------------------------------------------------------------
  258-  383 (187.73/150.26)	TYEKDG...KVIGRSTTRPSSDDESLEARVLEARNTIFSQELW.HELTKESRSLAAYDVKPEGRKLACQIDErTKITLeLLPLES.....CPSPEQDMPE.NGLAEKISMALHILLSyahryNELMRIRPIPPHIS
  420-  548 (186.55/127.99)	TLQKAGiqsSFILRTTQTNASDPNSRGPNQLSTSHTLVRNLLQtQDFTIELTILPDISLTIRGRSFSFPVTA.TYYYI.LLPPSSplpamCPPWSEGYPSvQALGDYLRTAIVCILT.....NHFVKMLSSPSSTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.72|      15|      16|     186|     201|       2
---------------------------------------------------------------------------
  186-  201 (24.61/20.35)	SKYWED..IVGVkKAGWS
  203-  219 (22.11/12.85)	SRVPQErhTLGV.RFGFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.01|      15|      15|     151|     165|       3
---------------------------------------------------------------------------
  151-  165 (27.35/14.70)	DQEATAMGWTLMEIN
  169-  183 (23.66/11.92)	DSAEEAASFLEKEIN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.02|      15|      15|      62|      76|       4
---------------------------------------------------------------------------
   62-   76 (24.49/17.93)	QDEEMS..EAAGEADIA
   78-   94 (19.54/12.78)	KDPNVArmEVLKNIDIA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20110 with Med17 domain of Kingdom Fungi
Unable to open file!