<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20107

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMHGPAVKKGHLYQYESSFVHASGPSHPHSSKSALFCVTVSGMLKMFWSQNNNRMEETTMELESVNSLDELVTHAALASDRRHLLVAVATSSKQLRLLKIEIQWGGPGSQPDKNPLPQNARLSPSLVEKHLAATTWLQTGSRDASNDISMAELSHLHVLPSIMDNTGKSIVPPTIVAIRTRSPTPGSYQVAQTVIDRWEAVSEPRQNLHPAFEQLGNRKNSDATEQTAPTRLRKLEPIVLNKMVINFQSIQFGKVLVLTMADGTVEYRDRYTFEEIYATEDTDKVMNLRQVGWTFGGEGPCQQVAFSPTQCSMIQMSEDGKIKWCKLQYPLGDIGNSNQDAHYAASVAGLAVATSSAVWYQANYDDMLAIVAPYTSKKRFIQDWINEMIKVLKIQVDYSEELHHDSLMRNLPLQNILSIMNSLGFKGEMHARSLQGKFAMVYLNARNVVVLITLASNMPATAREKMSPLDEPEVVEALAGCTKWSLDLLSWLVDCLFALMNDSEFMARLEPKRFGELAPYLHKRNDISLHLLLSSSSRSFLLAICRRIAHLEQLSIKANEFYRRQPQMGVDQSGAPKPLNPQLQQAYQKMQQITSSCLIKAGEFEKLLNILGADVRQAYQTFLPTFVKNQTGAPQGKQIDLAVKSAQIQIELSMLLAASPPAAPFLVVVKKLFTKDLPAFKALTDPSKLFFANYDLLGVQDDKSQLPRKIYIDIFRKAEMKLGAQQWRRCTRCASVMEDVFGTRPGYTFVLGQQRRCACGGVWALLPKGKLLL
Length772
PositionTail
OrganismTrichoderma asperellum CBS 433.97
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma.
Aromaticity0.08
Grand average of hydropathy-0.208
Instability index49.79
Isoelectric point8.89
Molecular weight86350.65
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20107
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.09|      22|      25|     712|     735|       1
---------------------------------------------------------------------------
  712-  735 (32.68/31.88)	DIF..RKAEMKLGAQQwRRCTrCASV
  738-  761 (39.41/25.51)	DVFgtRPGYTFVLGQQ.RRCA.CGGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.29|      12|      31|     576|     587|       2
---------------------------------------------------------------------------
  576-  587 (23.83/13.39)	KPLN...PQLQQAYQ
  605-  619 (16.46/ 7.30)	KLLNilgADVRQAYQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.18|      25|      40|     463|     488|       3
---------------------------------------------------------------------------
  463-  488 (41.05/31.39)	EKMSPLdEPEVVEALAGC....TKWSLDLL
  503-  531 (40.13/25.44)	EFMARL.EPKRFGELAPYlhkrNDISLHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.76|      34|      36|     294|     328|       4
---------------------------------------------------------------------------
  294-  328 (60.10/41.18)	FGGEGPCQQVAFSPTQCSMIQMSEDGKIkWCKLQY
  330-  363 (56.67/34.35)	LGDIGNSNQDAHYAASVAGLAVATSSAV.WYQANY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.92|      10|      24|     397|     406|       5
---------------------------------------------------------------------------
  397-  406 (18.52/13.67)	YSEELHHDSL
  424-  433 (18.40/13.54)	FKGEMHARSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.38|      19|      30|     103|     122|       6
---------------------------------------------------------------------------
  103-  122 (33.40/22.07)	WGGPGSQPDKNPLPQnARLS
  135-  153 (33.98/17.94)	WLQTGSRDASNDISM.AELS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20107 with Med16 domain of Kingdom Fungi
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