Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MDTYIDNRFERLEKALANLIDSVTKYHPSTVQAEELKTADDELCKGLEEVQTHQNNHLKIQQLRQLSTSLDSQIRETLTSLATTRKDIVTTQVTVYPSEPNYPIVYEELLSYARRISKTSMPPSAILNALASTQESQTPLPDSQTQAGMTPSAQTPNPTQSPAPVNGVLPSGLPDLSSTQQTQTSQLTSLPENMSQFLNPLSGQLFFPWPLEDKIRSGALASNQILLEQGIDPKGYDPVAEEERKAKEEEERKEKEEKEKQERAERERQRREELERLRKEDLLRREKEQAAFRRASTAAGISGDAAVNAPPSARPEKKQFQFTNLDDLDDDDDED |
Length | 335 |
Position | Middle |
Organism | Trichoderma asperellum CBS 433.97 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Hypocreales> Hypocreaceae> Trichoderma. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.933 |
Instability index | 55.40 |
Isoelectric point | 4.80 |
Molecular weight | 37764.34 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP20106 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 49.45| 15| 15| 243| 257| 1 --------------------------------------------------------------------------- 243- 257 (24.08/10.98) ERKAKEEEERKEKEE 259- 273 (25.37/11.88) EKQERAERERQRREE --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 44.01| 15| 16| 137| 152| 2 --------------------------------------------------------------------------- 119- 146 (17.09/10.40) TSMPPSailnalastqesQTPLPdSQTQ 147- 162 (26.92/13.20) AGMTPS...........aQTPNP.TQSP --------------------------------------------------------------------------- --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 39.66| 15| 15| 173| 187| 3 --------------------------------------------------------------------------- 176- 192 (19.84/ 8.72) LSSTQQTQTSQL...tsLPE 194- 213 (19.82/ 8.71) MSQFLNPLSGQLffpwpLED --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) AFRRASTA 2) PPSARPEKKQFQFTNLDDLDDDDDED | 291 310 | 298 335 |
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