<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20089

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMPSDLPQTPQSPSYDSTYFPSKLAASPRTGSSLPTPAHSINGSMSSTTPDVVAEAAHVEDPSNKRKRDIEDGGDRDQKKVHLEDSRLRIEDLHLDVGEKYLLCRTPHPPFPIPLKEDLFQRYGLTDLAETVARSNPDGSKKTVRKTYKGHIKRVLKLSGNFDSVKRGAEEPNSLVSMMCQPDEVWNAQYAQASKEIETGIPQPVLANLGKAVTMARGVIPKDMWNSSVLGELVPPSAPAQPAKGVQNGVKTQQPPQAAGVRTVKPEVPRPKRNIKKRTYGDASFEGYGEGFVDDDAQETGYSTGDGDERTGRKRPKKTIQSNSFQGPVARQNSYGPGMVGV
Length341
PositionHead
OrganismAmorphotheca resinae ATCC 22711
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Myxotrichaceae> Amorphotheca.
Aromaticity0.06
Grand average of hydropathy-0.806
Instability index52.18
Isoelectric point8.96
Molecular weight37174.26
Publications
PubMed=29315638

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20089
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     198.54|      47|     131|      26|      72|       1
---------------------------------------------------------------------------
   26-   72 (78.28/37.50)	SPRTGSSLP.....TPAHSINGSMSSTTPDVVAEAAHVEDPSNKRKRDIEDG
  163-  199 (60.64/27.69)	SVKRGAEEP........NSLVSMMCQ..PDEVWNAQYA.....QASKEIETG
  226-  275 (59.62/27.12)	SSVLGELVPpsapaQPAKGVQNGVKTQQPPQAAGVRTVKPEVPRPKRNIK..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.53|      34|     162|     119|     152|       2
---------------------------------------------------------------------------
  119-  152 (60.41/30.37)	FQRYG...LTDLAETVARSNPDGSKKTVRKTYKGHIK
  284-  320 (57.12/28.40)	FEGYGegfVDDDAQETGYSTGDGDERTGRKRPKKTIQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20089 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FEGYGEGFVDDDAQETGYSTGDGDERTGRKRPKKTIQSNSFQGPVARQNSYGPGMVGV
2) MPSDLPQTPQSPSYDSTYFPSKLAASPRTGSSLPTPAHSINGSMSSTTPDVVAEAAHVEDPSNKRKRDIEDGGDRDQKKVHLEDSRLR
3) NSSVLGELVPPSAPAQPAKGVQNGVKTQQPPQAAGVRTVKPEVPRPKRNIKKRTYG
284
1
225
341
88
280










Molecular Recognition Features






MoRF SequenceStartStop




1) PKKTIQ
2) SYDSTYFPSKLAA
315
13
320
25