<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20085

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMEPGEYQTNVLSSNSYGSIQYEYLEPLNISPAETWKHLQTLEATWRRDGLLVLCDPIRDGIWVFQNGTNHAPSSQESGVAETSNVVDVRGTDLVLRDRGTYEPASLAKGKILSATGLSVSSSPSSLENAARNVQSFNSRAVQANSSHNIMNEPLTPSPGLKPTTGVGESLPSLKDIHECFISAVLGSVVYFLCRDHGFVPLNSRTLILETPKLSFSHCSGSDISTGANVITLATLDISLTSLGTLVVKAYSDTAPGLQRLVNISSSAHPSPEIPSGTALWLAPGGNAAKFYGVQDEQKLPGNLPISQIQANYVGRRQHGFNGATIQSWQSKCLEWLAAKGLNSAALEDGGWVFVQVLTGNSPYLNPDSEGNPMLEGLTIIPWPALLCFQMSSTGNRESQSIAAKITERDPLSFAEEWFMSNDNRASITAKRQKERQLAEARSKEQADVDARNLHSITQSPTTLRRGSNAGAMYPTPPDAVHHPVGATPSFDGGVSTPGNQTQLFNQDVDAPTHDTISADIWGSSGKKERMTRNFHENDNDNDVLFRDSGDLFGDITDADFNFFDEPNVIMQDDQETGSPGDPVLSTQETSNALEMPRLDPTNEISLEVFRPSGDSNNASDPEQRPTELSKPDPSDLENAIVEKAPETVEDAPQPTSSPPFNKEAVFRRLFQASPLEKRSDQPRKLSSFTKIEFESSLTSVDEKYGTHGRFRFSDEGKGLQRVGSPTLPKTEYLSRRRKPTKKEPDFSGLARIFQRKESEIVDPVVDDDQSMLYPMDIDHASIVSEQDDTSHTTDDLSQALKPGVKRKWAMDDEGGDDMSSSFGALALEYAQSAGTPLSITGSQLPLLEGDPADWSLTTYFTSPEPDVQPIALTDLECIATAQILADQAVSGTIKLPGSRSGGNDVHSNSHKVSNTRELMHSLTRAARSCFKNITNCTMRSYLEIQGIPALSQGLRLPPRPVPNPRGGISDPTRAHNPFPINPPQLEVRRADSKLSVLPSAVSFWENLSLSPSSGSKDVNAVCVYPNLDGIAGNASIFLDQMRSAYESARLGGHDRVVCKELASGLVPFNVDLSQQTSKMHHLAALKETTARLSKILASLTVGEKNFVVYFIYPINNPSLLVHICSAFQHLFNLYRKALSDRKINAANELVLQLVPLDFIASPTSIVVPSPSEYARLAMEVYDRCIDFSSFSSTPAILLEQPLPKNIDFKLNANPSASLLQENSCLHIAYAQSIDDRWITAAWTDNRGTQQMTASYCLGRKNEPISMPFSGVANEIWETTLDIISSKKIHWRVMITRVGVMDRSEIEFWTGLASTESDAQINLTLITVQTDPSLRLLPAPVTLSPISNAAPAVVTPVSTPQASQASIVSPEAVSTPARDPANAATPVEPPVEPDSDARLIDYTDQSWGAVLAHRLNNSNSLLELNPALISGYLLKRGGINSDDPPIILEVNIVHSEVVGNPRTFHENLLREVLGYFRNLGTLARVRGVVDPVKDIRPWHVAAVEKAAKALYMLM
Length1513
PositionKinase
OrganismAmorphotheca resinae ATCC 22711
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Myxotrichaceae> Amorphotheca.
Aromaticity0.07
Grand average of hydropathy-0.343
Instability index47.24
Isoelectric point5.15
Molecular weight164987.03
Publications
PubMed=29315638

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20085
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     242.64|      63|     126|     999|    1063|       1
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  862-  904 (45.21/18.17)	..............SPEPDVQP.....IAL.TDLECIA.TAQILADQAVSGtikLPGSRSGG..ND.........
  999- 1063 (107.84/58.11)	SAVSFWENLSLSPSSGSKDVNA.....VCVYPNLDGIAGNASIFLDQMRSA...YESARLGG..HDRvvCKELAS
 1125- 1189 (89.59/43.49)	SAFQHLFNLYRKALSDRK.INAanelvLQLVP.LDFIASPTSIVVP...SP...SEYARLAMevYDR..CIDFSS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     319.78|      98|     124|      90|     198|       2
---------------------------------------------------------------------------
   90-  167 (101.03/65.34)	....................................................GTDLvlrDRGTyEPASLAKGKI...............LSATGLSVSSSPSSLENAA...RNVQSFNSRAVQANSSHNI.MNEPLT..PSPGLKPTTGVG
  168-  292 (125.35/86.44)	ESLPSlkdihECFISAVLGSvvYFLCRDHGFvplnsrtliletpklsfshcsGSDI...STGA.NVITLATLDI..............sLTSLGTLVVKAYS...DTA...PGLQRLVNISSSAHPSPEIpSGTALW..LAPGGNAAKFYG
  297-  385 (93.40/51.34)	QKLPG.....NLPISQIQAN..YVGRRQHGF...........................................ngatiqswqskclewLAAKGL....NSAALEDGGwvfVQVLTGNSPYLNPDSEGNP.MLEGLTiiPWPAL.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.92|      11|      25|     392|     404|       3
---------------------------------------------------------------------------
  392-  404 (15.09/14.36)	STGNResQSIAAK
  420-  430 (19.83/11.20)	SNDNR..ASITAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.78|      29|     546|     905|     933|       4
---------------------------------------------------------------------------
  523-  555 (35.25/25.04)	..SSGKKERMTRNFHENdndndvLFRDSGDLFGDI
  905-  933 (49.35/38.73)	VHSNSHKVSNTRELMHS......LTRAARSCFKNI
 1452- 1478 (47.18/36.63)	VHSEV..VGNPRTFHEN......LLREVLGYFRNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      94.05|      27|      27|     631|     657|       5
---------------------------------------------------------------------------
  620-  645 (25.26/ 8.77)	....DPEQrPTelSKPDPSDLENA...IV...EKAP
  646-  674 (40.42/18.12)	ETVEDAPQ.PT..SSP.PFNKEAVfrrLF...QASP
  676-  703 (28.37/10.69)	EKRSDQPR.KL..SSFTKIEFESS...LTsvdEK..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.71|      14|      15|    1356|    1369|       6
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 1356- 1369 (24.27/13.50)	VSTPQASQASIVSP
 1372- 1385 (25.44/14.55)	VSTPARDPANAATP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.55|      11|     131|     978|     988|       7
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  978-  988 (22.41/13.48)	FPINPPQLEVR
 1112- 1122 (22.13/13.20)	YPINNPSLLVH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.93|      25|     122|     467|     491|       8
---------------------------------------------------------------------------
  467-  491 (46.76/28.10)	SNAGAMYPTPPDAVHHPVGATPSFD
  495-  519 (41.17/23.74)	STPGNQTQLFNQDVDAPTHDTISAD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.07|      23|     149|     556|     582|       9
---------------------------------------------------------------------------
  556-  582 (38.29/32.29)	TDADFNFFDEPNVImqddQETGSPGDP
  706-  728 (41.78/24.39)	THGRFRFSDEGKGL....QRVGSPTLP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20085 with Med13 domain of Kingdom Fungi
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