<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20083

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMDNGDRPGSHTNHNRDQRLNGVNGGSYTAEKGQDKGKGRAELQQRMTPISPTPRNGANGAFAEALEGEVFTNPPDLQERINQLPPEIAHITHGYMSLSTLLQRLAVKTHEDLKAKILELSQMPVPSSAANGNASHVTSVDDNSADNVAKKLLLLNFAQNTHADWVKALVITNWSRRSEDVSKTIDLKLYLDDKKLLYETAIHELAQLKRTLPYSRLPNPDLKTALQVLSTGKAPWMPELGYIPPPPLTPADVLETLEKLNTLLSIRMNLHEYDNTPLQFKDYTIGSGRVTFRVAGEFELDLTIADEDPDKQFWFIDFRFLFSPTLPELTPYLRYHIESRVNAVLLTDGLPGCYKLLHEMVLTHKISECRRQASDLARGKWIEGLKVEPLNRALSIQYWLDRYGKKGPKSWIILGVHSGRRKDGRYDPKATSRLFIRWFRDGKEVKDADIPFDTVNISAEALLKTVIAKHINHILQSTYEKLQPRTLFSTGEMALTLSTSSDEPSESELKIQFAGQQYLSVMIEPITGKFILGPASLLSVRTEFALNSKSMDPANEAHGYIEMLRCEMAADEIITHGLSVGWIRIRKPDLKPEELKPVFPKDTLQVAWFRRTGWSKEWFVAVSLGMSGERWWLIETAVAPTLANTGRPNAPPPELKLVNYLEIPIKATSPIPTYKFLSTLSIFAAALISHYANLKALHARRANHVLRSSKISSPIQLPSIYVKLSEILPSKNKSKRTGQPWARNVVKLTFQGLESLPPMVLQALSSPNQQGLPPDATVSSGVQPPKKAVQEETAMIVTEARMMVPVPASLSILKERVDRDIAFHAESGTFAFRLRSRIGEAVIPALVERATRIERLVEFVEVLHKHEKTLTCESVSLGEIVFSYGSSLTPASAEASETGGLVQYRAVVDFGAAVNIMTLSLEQGNPHLRIADLLAKVLNGNEGLDGVAHLLPLTLPALRALDSLEAAWTPLSDNGEALVLVRAIEWYIIRYNFLSASPDSSSPPKPREVIFEIKLQQRKGEPWWFVRRTDARDREGDDIDGLLKPIWNSSGEGWKGMRVNAVAQPKGVEELLQKIDEVLRGMVSEQNLTQTQQAEAAPAPAQVPQVQAPQMAPVAPMTPMQIKAPQRPPFHTSNQQRPQHTQNQSQMQGRGNQVKPEVVEID
Length1166
PositionTail
OrganismAmorphotheca resinae ATCC 22711
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Myxotrichaceae> Amorphotheca.
Aromaticity0.07
Grand average of hydropathy-0.320
Instability index43.56
Isoelectric point8.03
Molecular weight129957.39
Publications
PubMed=29315638

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP20083
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     363.33|     108|     115|     492|     604|       1
---------------------------------------------------------------------------
  475-  528 (62.80/31.35)	.....................................................INHILQSTY............EKL.QPR.TL...FSTGEMALTL...STSSDEP.SESELKIQFAGQQYLSVMIE
  529-  639 (171.80/114.96)	PI...TGKFILGPASL.LSVRTEFALNSKSMDPaneAHGYIEMLRCEMAAdeIITHGLSVGWIRIRKPD..LKPEEL.KPV.FP...KDTLQVAWFR...RTGWSKE.WFVAVSLGMSGERWW..LIE
  644-  764 (128.73/75.15)	PTlanTGRPNAPPPELkLVNYLEIPIKATSPIP...TYKFLSTLSIFAAA..LISHYANLKALHARRANhvLRSSKIsSPIqLPsiyVKLSEI.LPSknkSKRTGQPwARNVVKLTFQGLESLPPMV.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.38|      31|      32|      25|      56|       2
---------------------------------------------------------------------------
   25-   56 (50.94/35.85)	NGVNGGSYTAEKGqDKGKGRAELQQRMTPISP
   60-   90 (55.44/34.55)	NGANGAFAEALEG.EVFTNPPDLQERINQLPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.99|      20|     115|     215|     244|       4
---------------------------------------------------------------------------
  215-  235 (30.46/28.58)	TLPYSRLPNPDLKTaLQVLST
  247-  266 (35.53/10.79)	IPPPPLTPADVLET.LEKLNT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.98|      38|     394|     412|     455|       5
---------------------------------------------------------------------------
  412-  455 (54.73/60.25)	PKSWIILGVHSGRrkDGRYdpKATSRLFIrwFRDGKEVKDADIP
  811-  848 (65.26/45.70)	PASLSILKERVDR..DIAF..HAESGTFA..FRLRSRIGEAVIP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.00|      19|     585|     274|     323|       6
---------------------------------------------------------------------------
  302-  323 (31.90/71.27)	FELDLTIADEDPdkqFWFI...DFR
 1015- 1036 (33.10/ 6.60)	FEIKLQQRKGEP...WWFVrrtDAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.57|      32|      32|     119|     150|       7
---------------------------------------------------------------------------
  119-  150 (52.40/30.43)	AKILELSQMPVPSSAANGNASHVTSVDDNSAD
  153-  184 (54.17/31.67)	AKKLLLLNFAQNTHADWVKALVITNWSRRSED
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.29|      28|     715|     344|     372|      10
---------------------------------------------------------------------------
  344-  372 (44.64/34.93)	RVNAVLLTDGLPGCYKLLHEmVLTHKISE
 1062- 1089 (46.65/31.08)	RVNAVAQPKGVEELLQKIDE.VLRGMVSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.50|      15|      15|     861|     875|      13
---------------------------------------------------------------------------
  861-  875 (24.44/16.23)	VEFVEVLHKHEKTLT
  879-  893 (24.06/15.87)	VSLGEIVFSYGSSLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.81|      10|      15|     948|     957|      14
---------------------------------------------------------------------------
  948-  957 (18.18/10.13)	LDGV.AHLLPL
  965-  975 (14.63/ 6.64)	LDSLeAAWTPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20083 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVIMDNGDRPGSHTNHNRDQRLNGVNGGSYTAEKGQDKGKGRAELQQRMTPISPTPRNGANGAFAEALEGEVFTNPPDLQERINQLPP
2) MVSEQNLTQTQQAEAAPAPAQVPQVQAPQMAPVAPMTPMQIKAPQRPPFHTSNQQRPQHTQNQSQMQGRGNQVKPEVVEID
1
1086
90
1166










Molecular Recognition Features






MoRF SequenceStartStop




NANANA