<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20082

Description Uncharacterized protein
SequenceMTARPDLGPRQPQRSSSASIAQRPPQPGRALSQQFAPSSSARRVEQAVVDLTFDAADAALGRPAIAPKNGGSPLKVDMTKDAKASTAVDPLKPAAEATPSWRPSLPPRGRPLLHFDLPSTNSPNSRAAEDGAQPGVTIKPMPLPVRPGRNAPSSFDKARIASRTPPKKDARPKPYTLEVPTAAPHYPPNGHADFFPWTGKHPEDRFTEATIRQGFFDKAQMTQNETGSAKASILPPLKHKSGLQTLSSLFTSVLAQRRAHGQITSSSTFKPPPRVTVTDTKREMWLKDLANPAISLRRLSRSIPHGIRGKVLLDQSLSKNIPLERAVWLAKCVGANELRSFRRKGANGLPMGGEGKWIRDFTVCVEQFVESAVGSCGEKDFRSRVNYVIRLSAHFHAEHLLDRDHYLDWLVSSLENSQQAKLPMWLLITQIYWKDILHYRKFGRRLSTALLNHWAATMVHPDRDILVPLSDRLELALKELMESHPESFVSSIGWTKHRTLIQTSLAPDDARFAALFASIDRRNSRLAAPTAKKEPSPRKCLIQLLDTTLEKPFTSELLEQCWQVDDDKDILVQAVLEWATSFYRPGTAKIYVAVRLLRHWTRSGVDVTQGILSFLDSKACERGRNKPALYHLVCELARSEHFSTPMYLQWVIARGGLYDAADVARGGPCATRLLAELPVHNFTESMDTLRRTLLSRADFSVDDEEEQIRAYMAFLAKCLPGMQANVDLESDPDVAIADDKIGFSPELSRGSKSEVGLWLRQKVRLQMLQPTIPPLDDWDDSPMKGGTSAITLSDFNIVRQSLEHMEDFSILADVLKMVSSSNDAEVLASCADTINLHLDSFAAIGALKSLFEILTGRLRSLTEDDSFPRVLLVSLSELAARIPEQNDVARQLAQELSRSDRKTAADACSPVSDHMAGVTQSAESDFTDEMEKVLGSGNNMDQATLERLFQRIAIRLEGSWEKSQEQYRSCGLLFTRLRTFDAQRFDVLMAAWVNRVLQMESRPSMIQVFGPLISFGCLALQDVVSNCVSVIENEMALHNSIPSKVAEEVLALLIAPSSIPETMSDEEAYRLRVKQANMQRDHSLDILSVIRRSFLDALDSNQVQPGAAPAQVETLLGRIYGFLQRLVLVDTDSIIQRLIVPLLSSASMGAAATVSAIVDGLLTDGKRNADTPIPIDVVVSLADCLTLPFCQVKLASIFIQDKSSPTTVDESDSECLQAFDNAIGSAVTAGNTAWAYLIPSLDISIVRHLRKRAETEFISICPSLKTASTEDIPTMRSRIQQANNLLYIVDATTSSLSVPTSATSLAPEIVTVLNNMWLLLCGTQIQVPEMKELMITEWLPLLLSFTTIHTSAFEETKAGHEDRSKALLALAAIMLELQALDNSTGIINTTTQDTFDIALHLVDALPDDMRQQCIRSLRDTISNRQVSYLFSIPTDPSGWLVLSQKERIGGSGGAEGRGIDIEKEKLAPFPLRRWEMLGEPTPNVGENDTSLSLTLFDARRY
Length1501
PositionKinase
OrganismAmorphotheca resinae ATCC 22711
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Leotiomycetes incertae sedis> Myxotrichaceae> Amorphotheca.
Aromaticity0.06
Grand average of hydropathy-0.210
Instability index45.99
Isoelectric point6.14
Molecular weight165964.60
Publications
PubMed=29315638

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. Component of the srb8-11 complex. The srb8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The srb8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20082
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.81|      16|      18|     861|     876|       1
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  861-  876 (25.66/14.68)	LTEDDSFPRVLLVSLS
  882-  897 (26.16/15.11)	IPEQNDVARQLAQELS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.04|      58|     117|     798|     859|       2
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  798-  859 (84.38/83.84)	VRQSLEhmEDFSilADVLKMVSSSN..DAEVLASCADTINLHLD.SFAAIGALKSLFEILTGRLR
  918-  978 (89.66/72.66)	VTQSAE..SDFT..DEMEKVLGSGNnmDQATLERLFQRIAIRLEgSWEKSQEQYRSCGLLFTRLR
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.43|      23|      24|      50|      73|       3
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   50-   73 (35.81/23.63)	DLTFDAADAALGRPaIAPKNGGSP
   77-   99 (38.62/21.48)	DMTKDAKASTAVDP.LKPAAEATP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     360.47|     102|     891|     410|     511|       4
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  197-  315 (103.63/65.55)	W..TGKHPE.......................DRFTEATIRQGFFDKaQMTQNETGSAKASIlPPLKHKSGL............QT............lSSL...ftsvlaqrrahgqiTSSSTFKPPPRVTVTDTkreMWLKDLA.......................NPAISlRR..LSRSiphgirgkvLLDQ
  328-  453 (127.17/82.39)	WLAKCVGANelrsfrrkganglpmggegkwiRDFTVCV.............EQFVESAVGSC.GEKDFRSRVnyvirlsahfhaEHLLDRDHylDWLV.SSL.................ENSQQAKLPMWLLITQI...YWKDILH.......................YRKFG.RR..LSTA.........LLNH
  454-  599 (129.67/84.18)	WAATMVHPD......................RDILVPLSDRLELALK.ELMESHPESFVSSI.GWTKHRTLI............QTSLAPDD..ARFA.ALFasidrrnsrlaaptakkEPSPRKCL.IQLLDTTLekpFTSELLEqcwqvdddkdilvqavlewatsfYRPGT.AKiyVAVR.........LLRH
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     109.39|      20|     118|      24|      43|       5
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    6-   24 (28.46/12.70)	DLGPRQ.PQRSS...SASIAQRP
   25-   44 (30.60/14.28)	PQPGRALSQQFA...PSSSARRV
  128-  147 (26.45/11.22)	AEDGAQPGVTIK...PMPLPVRP
  165-  187 (23.89/ 9.33)	PPKKDARPKPYTlevPTAAPHYP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.94|      11|      20|    1231|    1241|       7
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 1231- 1241 (20.74/12.23)	NTAWAYLIPSL
 1254- 1264 (20.20/11.70)	ETEFISICPSL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     343.10|     112|     159|    1107|    1224|       8
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 1107- 1224 (167.56/143.31)	AAPAQVETLLGRIYGFLQRLVLVDTDSiiQRLIVPllSSASMGAAATVSAIVD.GLLTDGKRnADTPIPIDVVVSLADCLTLPFCQVKlASIF......IQDKSSPTTVDESDSECLQAFDNAIG
 1267- 1385 (175.54/127.60)	ASTEDIPTMRSRIQQANNLLYIVDATT..SSLSVP..TSATSLAPEIVTVLNNmWLLLCGTQ.IQVPEMKELMITEWLPLLLSFTTIH.TSAFeetkagHEDRSKALLALAAIMLELQALDNSTG
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20082 with Med12 domain of Kingdom Fungi
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