<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20080

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMDKYIDERFERLERALANLTDSIANYTPQPAAAHELMAADRALADGLQQLQIHQNNYALIVRLRAESDALDAQIRDTLNLLWTTRRDMSSVNITTFPELQHHDVNWEELLSYARRISKTTLPAPSILSAAAAAANGTATGINGEDGGMSTGDAAGTPNTATAAPTPAPGVGTPAAVNGMVKSPAPSAQIAVPLQQVVPSGTALPDDWNRFLDPLTDMTFQPWPTEDKIRSGALAALEELAMQGIDPRGFDPAEEEARRQREEEERRVQEEREAREREDNLRKMREDQARIARERQRERERAQEEALRRGSMGGPTTAAEGLSPTTAQPARKQFQFMGDMDDDDDD
Length345
PositionMiddle
OrganismConiella lustricola
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Schizoparmaceae> Coniella.
Aromaticity0.04
Grand average of hydropathy-0.732
Instability index58.28
Isoelectric point4.72
Molecular weight38024.64
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20080
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.26|      24|      30|     147|     173|       1
---------------------------------------------------------------------------
  147-  173 (41.35/28.00)	GMSTGDAagtPNTATAAPTP..AP.GVGTP
  178-  204 (32.91/15.29)	GMVKSPA...PSAQIAVPLQqvVPsGTALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.89|      18|      31|     253|     270|       2
---------------------------------------------------------------------------
  253-  270 (29.23/13.68)	EEEARRQREEEERRVQEE
  277-  294 (27.66/12.60)	EDNLRKMREDQARIARER
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.75|      11|      22|      41|      52|       3
---------------------------------------------------------------------------
   41-   52 (15.02/11.29)	RALADGLQQlQI
   64-   74 (18.73/ 9.46)	RAESDALDA.QI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      27.14|       8|      30|     211|     221|       4
---------------------------------------------------------------------------
  211-  221 (11.57/12.49)	LDPltdMTFQP
  244-  251 (15.58/ 7.22)	IDP...RGFDP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20080 with Med4 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ANGTATGINGEDGGMSTGDAAGTPNTATAAPTPAPGVGTPAAVNGMVKSPAPSAQIAVPLQQVVPSGTALPDDWNRFLDPLTDMTFQPWPTEDKIRSGALAALEELAMQGIDPRGFDPAEEEARRQREEEERRVQEEREAREREDNLRKMREDQARIARERQRERERAQEEALRRGSMGGPTTAAEGLSPTTAQPARKQFQFMGDMDDDDDD
134
345










Molecular Recognition Features






MoRF SequenceStartStop




1) EALRRG
2) TTAAEGLSPTTAQPARKQFQFMGDMDDDDD
304
315
309
344