<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20074

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMEIGTTQNGTVVRNNHDRNLKIANGANGAVMKRDPSPNKAKQAAISSTPITNGSLNAQQQLQAGSNATDTTMTSSNPPEIAHITANFIPLPFILQRLAQKSHNDLQTKIEELARMPPLQTSINGNTANVQEDSSEENQNKKANLLGFLNELHTKWTKTLVMSEWSRKSGQVSKLIDLHSHILEQLRKYDMILDRIGHIKRNLYGARLPDPDIKTALQVLSTGRADWMPDFTFIPPPALKADEIQNWVAELNTLLAFRLNLHDYNKRPYAFRNFSIADGRATFKVDGEFEVDLTIADDDPESQWWFINFRFNFSPTPPELNDKVWHFVESSVNDALARDGLKGCYDFLHGYVLTYKIRELQRQAVLLSKQHWIDNLKVEPLNRALCIQYWAQRYPGTGPNPDTNAGPKSWIIVGVNSGKTPQAGAIPTLHPTSYINIRWFRDGKEVTDDDVLFDTDSISAESLLKQIICKHIKHILTSLCNKLMSKPRYSSRQANISMKLHKTEPSQSYLKVQLTHSETLAIQLNTVTGNFYFEPAKAVTSKREAQLNARARDAVEDGFNQIESIRWQCLMWELARLGRPMGWTMCKRPVQPDEAKKLHSSREPYQSLWLKRENWGPAWYIVVCLSLAGDAWWLVELTEDSPQQAKAGSASVVNRPPNQLANVRAGNVPQQPTARIKSQHGLPIKSLNPELSTEFFSLLNNNANLTICAIRDWIQKPGSSSKPACGFIQAGNSSSLQNKLLPQMFFKASAVMQSLSSTGHNQIASKSNLSWAGEHFALKYRDEISGPNGQIQILHEVTVAVKDKSMFSLIKQEHVDRDVRYDAKAGHFIMQIRRTLRESCLPLIATRIKAINRLVEFVTAISGCAGGVESESVTLCQFVFTYGDNHERPEASGKRWKVTLDLADQQQLKISLEPDNPHIRVIEMLNKVVNSARGMKELPRVLQLTLPLHRALDATVAAWHTVFLNNQGTLRMVLHRIDWLVLQFDLPPPANTKTTTANSKSAERSLRLSINTKVRCEEQWWEVQRVSNPGAALDEFDHALRPIFTSRMAPGGWHGLETSAIVKIDGVGIEALLRAISLAIVSLAMGTSGPALQGGAAGGGAGGGMSRGAAIVLD
Length1113
PositionTail
OrganismConiella lustricola
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Schizoparmaceae> Coniella.
Aromaticity0.07
Grand average of hydropathy-0.361
Instability index41.37
Isoelectric point9.05
Molecular weight124204.15
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20074
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     237.00|      78|      96|     418|     510|       1
---------------------------------------------------------------------------
  418-  510 (111.31/113.32)	KTpQAGAIPTLHPTSYinirwFRDGKEVTD..............DDVLFDTDSISAESLLKQIIcKHIKHILTSLCNKLMskpryssrQANISMKLHKT.EPSQS.YLK
  517-  610 (125.68/84.17)	ET.LAIQLNTVTGNFY.....FEPAKAVTSkreaqlnarardavEDGFNQIESIRWQCLMWELA.RLGRPMGWTMCKRPV........QPDEAKKLHSSrEPYQSlWLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.38|      16|      96|      24|      43|       2
---------------------------------------------------------------------------
    8-   23 (27.96/23.50)	NGTVVRNNHDRN.LKIA
   27-   43 (24.42/15.60)	NGAVMKRDPSPNkAKQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     350.76|     125|     605|     197|     375|       4
---------------------------------------------------------------------------
  197-  348 (194.96/180.01)	HIKRNL.YGARLPdpdiKTALQVLSTGRADWMPDFT...........FIPPPALKADEIQnwvAELNTLLAFRLNLHDYNKRPYAfrnfsiadgratfkvDGE.FEVDLTIADddpESQWWFINFRFNFSPTPPELndKVWHFVESSVNDALARDGLKGCYDF...LH
  813-  948 (186.49/113.49)	HVDRDVrYDAKAG....HFIMQIRRTLRESCLPLIAtrikainrlveFVTAISGCAGGVE...SESVTLCQFVFTYGDNHERPEA...............SGKrWKVTLDLAD...QQQ.....LKISLEPDNPHI..RVIEMLNKVVNSARGMKELPRVLQLtlpLH
 1016- 1026 (-30.69/15.50)	....................................................................................................................EEQWWEVQ.RVS........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.24|      30|     608|      56|      89|       6
---------------------------------------------------------------------------
   56-   89 (47.32/37.45)	NAQQQLQAGSnatdTTMTSSNPPEIAHITANFIP
  639-  668 (51.92/31.37)	DSPQQAKAGS....ASVVNRPPNQLANVRAGNVP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      93.83|      21|     320|     381|     408|       7
---------------------------------------------------------------------------
  381-  401 (43.13/19.20)	NRALC.IQYW......AQRYPGTGPNPD
  703-  723 (30.76/10.19)	NLTICaIRDW......IQK.PGSSSKPA
  736-  760 (19.93/12.58)	QNKLL.PQMFfkasavMQSLSSTGHN..
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20074 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLQTKIEELARMPPLQTSINGNTANVQEDSSEENQNKKAN
2) MEIGTTQNGTVVRNNHDRNLKIANGANGAVMKRDPSPNKAKQAAISSTPITNGSLNAQQQLQAGSNATDTTMTSSNPPEIA
104
1
143
81










Molecular Recognition Features






MoRF SequenceStartStop




NANANA