<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20073
Description |
Mediator of RNA polymerase II transcription subunit 18 |
Sequence | MYELFMTAFVREADVNTLLAILSGYAWDSPRHRVHRVLHFAGASPNQPRGITKRSHIQEVPAEPDVFSLGLPNSTEVSQQQTTIADWKQLSDILSKQSYHVTTRYLVHKDGHFGKSEPLPDNYFNTNPGALFWSDMPDPATVSGQQTLVLQRQKIELHDQLNLSTVLTENSFVYKAEHVEEAYDIYHRDDPVEFHLVRCYRAPAQAAGAGRSHGPAATLPALESLEHATPGKWMLTAVAYVTEDMTPDKIQAARDALFKVREDMGPCGIVFKEIDRRHFDTQIAAARKPMSQALGKTQSLVGPAGGAR |
Length | 308 |
Position | Head |
Organism | Coniella lustricola |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes>
Sordariomycetidae> Diaporthales> Schizoparmaceae> Coniella.
|
Aromaticity | 0.08 |
Grand average of hydropathy | -0.419 |
Instability index | 43.26 |
Isoelectric point | 6.26 |
Molecular weight | 34344.33 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364150
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP20073
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 123.05| 35| 70| 13| 48| 1
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13- 48 (61.36/49.63) ADVNTLLAILSGYAWD.SPRHRVHRVLHFaGASPNQP
85- 120 (61.69/44.92) ADWKQLSDILSKQSYHvTTRYLVHKDGHF.GKSEPLP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 67.66| 20| 35| 249| 268| 3
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249- 268 (38.11/25.67) KIQAAR....DALFKVREDMGPCG
282- 305 (29.55/18.49) QIAAARkpmsQALGKTQSLVGPAG
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