<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20071

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDPGEYMTNTLLINNVSTVTFKIYEPTPSSSSPYASAALDVEHRLRNEGHLVYSDPLRRAIWSFSLGKPNDPSRGQSTGLQPGSGFDPSSHNLTLVEEGTLESISLFKNRIATPNVANTPSTSSPSGSGLDVGLRPPITPGGAVASMTLATESDLKLNMGASMDLKSYGAIPPKDVHEYFVASVLATLSQRFCARSGAIPLDARTLLLPSERPSADFEVTTSSNVSVFACFRVHLTTTGSLLIGICLTSVGGIWAGNDGLSAALPLNGNTVMAAPMGLLGTYQTLSDTDQYSIDGSTVQSPDTQITRYRSDQDARLTSLRSTYCNLLEMRGISTLSLAKSTWLSIQLLRRKSNEARTDGKKAPVVTNAQTHILWPAVLCYRKRMRSPVLIRDNSEVGHASLGDGFDALKDAQNWFQGSAEREDLFAKRKKERETASKSKEPGDMDSRLLQSGFSPAAPRRPSTTGAFGGVMYPTPPDGIQNAIGITPSIDGATSSPGNAMPSTVMVDIDTPLPASRGSTDAFNDGWDGPEVKREQSFNQENWDLNNDVFVENDITDADFNFFDDENPAELDNNIRDLPDLDNAVPGNEHSQAPDSVALQQQQQQQQQQQQQQQQQQQQHQQKQQQHHQTAVSNPVKPESCLVPPVFTKPELKHARSILERHRDPVKAGSNGIKRQSSPFDPSTVYKRLKLSLKVGASRDQNSARPGSAFDKLHFDSSFTAVNKKYEHNGRFDFIPEQSPTDTPRGENSPPTTGYLRRHGKSRSVPKELPNSLGAQVAGMAGSADQAMPNMDVPNADESTSDADDISLVSDQDDLSDFSDEPSSPIKLNAQRRRLIDDNESLAPSTRDFEVAEEHLAHALDLHKLQINDGAEVTLAQYFADPEPLPPRALLSDDEYIMVAQVLTEQAVSGTLDFSILEPMQDGLEPSRPRREILHHTRNLLQTLQELLPPCLQTATRCTLRQLVDVQDVPLLSTPSRIQPRPPGGPDQRPSLVQIVAPHLELRRYETKLSVLPSAVNFWESLGLGPSQGPKDVLSVCVFPNLEGMGDNADLFLNRLGNAYEALKLGGFERMPSSPTIVNGLVPFEVDRATNTPTLSQGSRSGQPLVDDMAKLAVAIFNTTTVPKNFVIFFVYTPNNPSTIVEACLAFQRMFELYKRAMTERKKPAQNELVLQLIPISLVATSTSMVVLSPTDSIRLSLEVYDRCTLFEGPMPSPAIVLEQQLVTQGINFQLRNQPSANVLQENSVMHIAYAQSVDERWISAAWTDNRGSKQMTASYCLGRKGKQLTRSFSDVAHEIWTTTYDLTSIWKVHWRIIITKVGAMDQQEINDWIALAQTEAKAAFTLVILTVDTDPSLQLIPDIPKPSVAGQTAFYSTPASTPQPSVMSPDAAGNPSTPKGGLTANSTSTPGADNNATEVDADASLVDITDITWGAVLSHRLNTSNSLTDPSPALISGYLIKRGGSRVDDNPAVMEVNVVHCEGNPRVLEMLLREMLSVFRGLGTIARARSVTEQEGDVRPWHVAAVEKAVRTLYQLM
Length1533
PositionKinase
OrganismConiella lustricola
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Schizoparmaceae> Coniella.
Aromaticity0.06
Grand average of hydropathy-0.402
Instability index47.71
Isoelectric point5.27
Molecular weight167478.02
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20071
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     104.39|      23|      87|     476|     498|       2
---------------------------------------------------------------------------
  476-  498 (44.53/19.91)	PDGIQNAIGITPSIDGATSSPGN
  567-  587 (37.08/15.56)	PAELDNNIRDLPDLDNAV..PGN
 1394- 1407 (22.78/ 7.20)	PKG.....GLTAN...STSTPG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      67.62|      13|      15|      71|      83|       3
---------------------------------------------------------------------------
   55-   67 (22.36/10.92)	DPLRRAIWSFSLG
   71-   83 (23.78/12.10)	DPSRGQSTGLQPG
   87-   99 (21.48/10.19)	DPSSHNLTLVEEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.16|      23|      35|     630|     663|       4
---------------------------------------------------------------------------
  630-  652 (41.61/49.01)	AVSNPVKPESCLVPPVFTKPELK
  667-  689 (40.55/20.65)	AGSNGIKRQSSPFDPSTVYKRLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.68|      17|      17|     940|     956|       5
---------------------------------------------------------------------------
  916-  937 (23.15/11.88)	LEPMQDGLEPSrprreILHHTR
  940-  956 (30.53/18.40)	LQTLQELLPPC.....LQTATR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.18|      16|      17|    1064|    1079|       6
---------------------------------------------------------------------------
 1064- 1079 (30.62/17.77)	LGGFE..RMPSSPTIVNG
 1080- 1097 (24.56/12.64)	LVPFEvdRATNTPTLSQG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.26|      38|      89|      13|      54|       7
---------------------------------------------------------------------------
   13-   54 (58.22/38.96)	INNVSTVTFKI....yepTPSSSSPYASaALDVEHRLR.NEGHLVYS
  101-  146 (57.03/27.41)	LESISLFKNRIatpnvanTPSTSSPSGS.GLDVGLRPPiTPGGAVAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     115.08|      29|      95|     865|     894|       8
---------------------------------------------------------------------------
  773-  797 (34.14/17.89)	....GAQVAGM......AGSAD.QAMPNMDVPNADE
  798-  832 (36.70/19.89)	STSDADDISLVsdqddlSDFSD.EPSSPIKLNAQRR
  865-  894 (44.23/31.26)	QINDGAEVTLA......QYFADpEPLPPRALLSDDE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.56|      38|      39|     983|    1021|      10
---------------------------------------------------------------------------
  974-  990 (21.58/ 6.08)	.....................PSRIQ.PRPPG.GPDQRPS
  991- 1030 (59.63/34.27)	LVQIVAPHLELRRYETKLsVLPSAVNFWESLGlGPSQGPK
 1033- 1062 (43.35/20.13)	LSVCVFPNLEGMGDNADL.FLNRLGNAYEAL.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.87|      29|     621|     693|     736|      11
---------------------------------------------------------------------------
  693-  724 (39.68/47.66)	KVGASRDQNSArPGSAFDKLHFDSsfTAVNKK
  739-  767 (53.19/22.99)	PTDTPRGENSP.PTTGYLRRHGKS..RSVPKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.32|      13|      70|    1347|    1359|      15
---------------------------------------------------------------------------
 1347- 1359 (24.52/15.44)	VDTDPSLQLIPDI
 1415- 1427 (21.79/12.80)	VDADASLVDITDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.30|      16|      17|    1445|    1460|      20
---------------------------------------------------------------------------
 1445- 1460 (28.07/19.51)	DPSPALISGYLIKRGG
 1464- 1479 (29.23/20.68)	DDNPAVMEVNVVHCEG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20071 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DITDADFNFFDDENPAELDNNIRDLPDLDNAVPGNEHSQAPDSVALQQQQQQQQQQQQQQQQQQQQHQQKQQQHHQTAVSNPVKPESCLVPPVFT
2) EHNGRFDFIPEQSPTDTPRGENSPPTTGYLRRHGKSRSVPKELPNSLGAQVAGMAGSADQAMPNMDVPNADESTSDADDISLVSDQDDLSDFSDEPSSPIKLNAQRRRLIDDNESLAPSTRDFE
3) ELKHARSILERHRDPVKAGSNGIKRQSSPFDPSTVYKRLKLSLKVGASRDQNSARPGSAFDKLH
4) FAKRKKERETASKSKEPGDMDSRLLQSGFSPAAPRRPSTTGAFGGVMYPTPPDGIQNAIGITPSIDGATSSPGNAMPSTVMVDIDTPLPASRGSTDAFNDGWDGPEVKREQSFNQENWDLNNDVFV
5) QTAFYSTPASTPQPSVMSPDAAGNPSTPKGGLTANSTSTPGADNNATEVD
553
726
650
425
1367
647
849
713
550
1416










Molecular Recognition Features






MoRF SequenceStartStop




1) FFDDE
2) TVYKRLKLSLKV
561
683
565
694