<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20065

Description Uncharacterized protein
SequenceMSSRPSIGVPQRQPPSRSLSGSASLSQRPAHQRALSSQYLQPSSPVRNNNNNNNNTSTSTATLSGSGSGTTSTTSTTSTTSNNNSGGGGNVLDYPSSDPSAASQAGNAAQAQFGTPRRGGSRLRLELANDGITHSGFVESPTNSGAFDPPKPFTPSRILPSAMASEAPDITEMSGSPRASRGGQAADNNHSNNNTTTNILADHNPPLPMPKRRCRFALPDKRKFRAAAAAALPPKRDTRPKPYSIEVPTAAPRWALLHGGSKDSQSRTSSSTSAPPMGFADFNPWTGDGPEDHFTQSFIQNGHFDKNPVGQAETGSGKIALFPSLKHKTGLYALSTVFTGLLGARRHNGQITTSSTFKPPPRVTVTDTKREAWLKDLANPASSHRRLSRTVPHGIRGKGLLEQCLNKNMPADRAVWLAKCVGANEIRAFKRKGVNGAVVMGGEAKWIRDWTVFVEQFVDGVVASFGDPDWKRKVNYAIRLASHLYAEHLLDRDHYMDWLVLSIENCPSAKLPMYLLIIQIYWKDLLRLRKYGRRLVAALLGQYTTIYNHPDRDILAPLSKSLLHLIRTLITSTTVNFLSPTTWPKHKEALAAALQPDDESAQAAYRTINARNEQLLSSARAPSAARAILLKQLDGALQAPFSEDLPVKCWNLTKDKQAFVRITLEWCTSSYRPGQAKVYIAHRLLTDWAALGLHTTKAVLDFMVSDPLRQMDRKSALYHLVSELFHSGHFQPLAYIQWLIARGGLYDTTAVDQDGPATTRLLVELPVYALADSLRTMRANMLGRAGYSVDDEAINAKTAINAVKNSLGIHWTNAPQTTSAIPIDKICKRINKSSRALKSEIGQCLRQLFVLEIVQAQSANKQDLQFPTSTFLSLRLILEAAEDFKTLGELLKTVSGFGDADILSSCADTLNLHLPTFGALGIAKDVFDSLVQRLGNLTQTQGIVFVRPLLASMAMLAPRIPGQETLVNHLNEAIRNDRNSAVDASSPVSDNMAARMQDEEGELLDEFEKRLANKTSMDRTTMNSFLNKIIPKIQACWAEADERLRAYSSLLARLRHFDTQHFDSFMTKWVLGIRNPQSRPPLTQIFPLMIISGCLHFSVILTTTGDAVSGPGRPNLAAKPGARPSTYIQEVLELLTAPPLPGKDLLTAEELYRFRIMQNQAPKTHFRELVVLIRNALIEFCAGKNQRDAALVPLSNPKAMDRLKNLLRILVLTDQQNVPKLLNVKALDATVAKMLDNITTQLLLPEEQPDMEFTFEQVLGMTNELTLPLCQLKLSQCMSTMEASGANPQDRLQTQLEVYSKALDKAIDTRNISWTGILPWLPAEIMQHLLALAQTRLFNLLPSIKNPVPAEGSFAAAETLLAVIETISRGRQTQLASAVVDRLADVWELLASPSSTPESNITDTAKVHVLLNWLPLMLSFLALHGHVQETPSKSNGEIRGRALLILTGLLQELEVLSSSLTTNSDSHSNSGVPSGHIPQLAQRTFDLALLFVDTLPDEGRLQCIRHLREALLDQRLRYIFSYAPQPHDNLVLVHKDGSSSKLGAGTTTAAGSAQGQGQPQQQQQRPRGTGFLGVGSLGQHVYGVPIPAGAGGVPGERMSAFTFRRWEILNEPTPTTGDNVTSLDLRLFEAIKLQ
Length1634
PositionKinase
OrganismConiella lustricola
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Diaporthales> Schizoparmaceae> Coniella.
Aromaticity0.06
Grand average of hydropathy-0.270
Instability index43.55
Isoelectric point9.25
Molecular weight178994.93
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20065
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     299.96|      57|      82|     149|     205|       1
---------------------------------------------------------------------------
   10-   59 (59.79/25.59)	.......PQRQPPSRSLSgSASLSQRPAHQRAL.SSQYLQPSSP......VRNN.NNNN.NNT..STS.......
   61-   94 (24.53/ 6.21)	.............................ATLS.GSGSGTTSTT......STTS.TTSN.NNSggGGNVL.DY..
   95-  146 (39.48/14.43)	............PSS.DP.SA.ASQAGNAAQAQfGTPR..RGGSrlrlelANDGiTHSGfVES..PTNSGA....
  149-  205 (105.45/50.69)	P......PKPFTPSRILP.SAMASEAPDITEMS.GSPRASRGGQ......AADN.NHSN.NNT..TTNILADHNP
  233-  284 (70.72/31.60)	PpkrdtrPKPYSIE..VP.TA....APRWALLH.GG...SKDSQ......S..R.TSSS.TSA..PPMGFADFNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     315.89|      81|      86|    1129|    1209|       2
---------------------------------------------------------------------------
 1129- 1209 (130.91/83.36)	QEVLELLTAPPLPG...KDLLTAEELYRFR...IM...QNQAP.KTHFR.ELVVLIRNAL.IE.FCAGKNQRDAALVPLSNPKAMDRLKNLLRI
 1216- 1298 (108.70/67.81)	QNVPKLLNVKAL......DATVAKMLDNITtqlLL...PEEQP.DMEFTfEQVLGMTNELtLP.LCQLKLSQCMSTMEASGANPQDRLQTQLEV
 1310- 1383 (76.27/45.10)	RNISWTGILPWLPAeimQHLLALAQTRLFN...LLpsiKNPVPaEGSFA.AAETLL..AV.IEtISRGRQTQLASAV.......VDRL......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     155.73|      53|     285|     651|     717|       3
---------------------------------------------------------------------------
  651-  708 (80.81/69.58)	NLTKDKQ.AFVRITL.EWCTSSYR.PGQaKVYIAHrlLTDwaALGLHTTKAV.LDFMVSDPL
  936-  992 (74.92/40.34)	NLTQTQGiVFVRPLLaSMAMLAPRiPGQ.ETLVNH..LNE..AIRNDRNSAVdASSPVSDNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.59|      26|      81|     389|     417|       4
---------------------------------------------------------------------------
  389-  417 (44.78/35.24)	RTVPHGIRGKGLL..EQCLNKNMPADravWL
  472-  499 (43.80/26.63)	RKVNYAIRLASHLyaEHLLDRDHYMD...WL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.72|      51|     191|     592|     643|       5
---------------------------------------------------------------------------
  592-  643 (79.87/51.20)	AALQPDDEsAQAAYRTINARNEQL.LSSARAPSAARAI....LLKQLDGALQAPFSE
  785-  840 (76.85/45.03)	AGYSVDDE.AINAKTAINAVKNSLgIHWTNAPQTTSAIpidkICKRINKSSRALKSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     189.69|      60|     530|     521|     584|       6
---------------------------------------------------------------------------
  521-  584 (96.20/71.78)	YWKDLLRLRKYGRRLVAALLGQYTTIYNHPDRDilAPLSK........SLLHLirTLITSTTVNFLS..........PTTWP
 1047- 1124 (93.49/58.31)	YSSLLARLRHFDTQHFDSFMTKWVLGIRNPQSR..PPLTQifplmiisGCLHF..SVILTTTGDAVSgpgrpnlaakPGARP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20065 with Med12 domain of Kingdom Fungi
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