<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP20061

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFIKTCNTNAQAIGDFEAVAYHAFTVARNPSATSSKRNEWSPTEDIRAVEAELRQAHHLVVQDVSRSWLWLFQASTADKVGQKPGDLPMLEGYRFQREQYGVMKASELARPPPLRPTNPTAPPPVSVSSPSTSGSMKGLQGGGSRPNSGASLSHSGSDHQQQPHDSCAIYELFTSSVVALISYYLVRDHQAVALNYRTFVSKPIASQDPDQSSLKPSEDPYWLTDVHVYLTSSGTLVASISSLQRPEIGSLADLATDDEQRQTIGTCIRVAPNGLLAKVVSFDEPIDAATEDASQRLQRKRPKISPVEQGIGRWKAAVKRWLSWKGYHVADLDKRASWVKIRIAHSKQPVASSPALPPQSREVLWPRAFCYFYEDSAPGRTDLPFPSRPAVSQEEGVLRWFQSAETPGYKNPIDAAQQWFLGKSERDKVVEAKKRAKKIEEEAARPKEENAHLYPSSPLNSRTGAYGDLQAVSGVYPTPPDGIAPGTMLSSSDTPSVTGAPTNVILVPGGSNPGINLLGPQDAMMTDGAVNHPTSPDLPLQFDQFNSGGGNDDLFEDMDGDGFDGNGVTDADFNYFDEPDGDDVHMLDAPTLQDGKATPAKKAAKEKEAHAQAEPKIKEEISDPLAALEHALDTASRHPEHGSQEAKSVLQEDPLLPDAHIKKPSTPPQIQRAVAPSSMTQTKEPTPPLSPHIIQKMLMPSPKDKALVVTPQRPSSSPHRDSVFDPLSFNRKMSASDAKYQDGRFSFYHTKPQHKAADVKEGWRRPTSLRDLPLLTKLRYAIGVAATKGIPEVASLQRADSDFSDVSSETSSSDDEDEDVEADDLLSLGPEPLSASVISTAKRKLPTEGNATPMSTTSIAESYGGDMLDFAGLHIDESSLASFEPTPYDWSLALVPPPSELSTPTTRYNVASFSPTVPSMPSTPTSQPDMDLPDEKPLSTKDSIAVAEVVTSQITSTTLDLLHEDKPVEAKRQDGRLSSELRFHSVIKEIFPKASDCNVSTLAAIPDIYPDIQQQTKGQQRPPPRKVNEGSSTLGHHMYQINTPHVRVRRADILWDLLPPALAFWEPLGLAPCSPAKNVVSFCIYPHSDSLRPCVENFLVNIQIAYDNCKLGSHARVETIQEYEGGLVPFKVSAPTSTRAAFKSLRDTCIQFGKVLGSKYAQMRSKDELKIDAFVIYMVDVGSTPSTLWELCSAFWACFQAYGQGPPARPDQPSKPDLVLQIVPVKYIASFEVPVIQDSTTYSNLAREVYDRCPPSAPSEDKTPLSIYTAPSFQLEEAVPRQIPFKLTSEPPQDLLRENSYMHLAYATSLDGLWITAAWTDSCGKSQYVASYNLGTRIFGEIAKEIWQTTVEIMQARRVTWRVCVAKAGVMEREELETWVYLISCPTSLNLFVTVLTVDTHPHLKFVPTIPNPTTNPTTTSSTNHVSANTPGSTPQAGVSPDPHSLTPAATPSAEPAADPLSDPDARFMDATDETWGIILAHRLHNSNSTNEFRPCIISGLLVKRGDPHPESTTSSTLQPLPDPERGPIVVGINIVWIGAVGSTRAATSPFPPSASSAEGVSPGPGQQGGPPAERSTSSLIWTPTVQARTTAENLLKEILGQYRALGLLGKLKGIRGTRGGGVPWHVAVAKRGVEGLGRCLG
Length1643
PositionKinase
OrganismCorynespora cassiicola Philippines
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Dothideomycetes> Pleosporomycetidae> Pleosporales> Corynesporascaceae> Corynespora.
Aromaticity0.07
Grand average of hydropathy-0.433
Instability index49.85
Isoelectric point5.58
Molecular weight178738.65
Publications
PubMed=29551995

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP20061
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     468.27|     127|     129|    1055|    1183|       1
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 1055- 1128 (98.05/66.96)	..................................................................LWDLLPpALAFW...EPLGLAPCS....PAKNVVSFC....IYPH..SDSLRPCVENFLVNIQIAYDNC..KLGSHARVETIQEYEGGL
 1130- 1252 (159.86/108.84)	PFKVSAPTSTRAAFKSLRDTCIQFGKVLGS....KYAQMRSKDELKIDAF..VIYMVDV.GstpstLWELCS...AFWacfQAYGQGPPArpdqPSKPDLVLQ....IVP......VK.YIASF..EVPVIQDST..TYSNLAR....EVYD...
 1253- 1381 (156.16/101.52)	RCPPSAPSEDKTPLSIYTAPSFQLEEAVPRqipfKLTSEPPQDLLRENSYmhLAYATSLdG.....LW.....ITAAW...TD....SCG....KSQYVASYNlgtrIFGEiaKEIWQTTVE.IMQARRVTWRVCvaKAGVMER....EELETWV
 1567- 1623 (54.20/29.33)	....................................................................................GQQGGP....PAERSTSSL....IWTP..TVQARTTAENLLKEILGQYRA....LGLLGKLKGIRGTRGGG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.75|      18|      18|     544|     561|       2
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  544-  561 (34.76/20.72)	DQFNSGGGND...DLFEDMDG
  562-  582 (27.99/15.10)	DGFDGNGVTDadfNYFDEPDG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     332.80|     100|     291|      12|     120|       3
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   12-  120 (156.99/115.61)	QAIGDFEAVAYHAFTVARNPSATSSKRNEWSpteDIRAVEAELRQAHHLVVQDVSRSWLW..LFQASTADKVgqkPG..DLPMLEGYRFQREQyGVMKASELARPPPLRptNP
  310-  413 (175.81/103.37)	QGIGRWKAAVKRWLSWKGYHVADLDKRASWV...KIRIAHSKQPVASSPALPPQSREVLWprAFCYFYEDSA...PGrtDLPFPSRPAVSQEE.GVLRWFQSAETPGYK..NP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.84|      16|      19|     889|     906|       4
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  889-  906 (27.26/20.07)	YDwsLALVPP..PSELSTPT
  909-  926 (26.58/11.99)	YN..VASFSPtvPSMPSTPT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.95|      20|      22|     658|     678|       5
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  658-  677 (37.20/13.19)	PDAHIKKPSTPPQIQRAVAP
  712-  727 (28.06/ 6.49)	P....QRPSSSPHRDSVFDP
 1442- 1461 (34.68/11.57)	PDPHSLTPAATPSAEPAADP
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.39|      15|     231|     521|     541|       6
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  478-  492 (28.93/ 9.46)	PT.........PPDGIA..P.GTMLSS
  502-  528 (12.46/ 7.77)	PTnvilvpggsNPGINLlgPqDAMMTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      95.76|      22|     231|     738|     759|       7
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  609-  624 (24.87/12.30)	EAHAQ.........AEPKIKE...EISD
  738-  759 (42.28/26.38)	DAKYQDGRFS...FYHTKPQH...KAAD
  970-  997 (28.61/15.33)	EAKRQDGRLSselRFHSVIKEifpKASD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.14|      13|      15|     246|     258|       8
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  246-  258 (21.54/10.89)	RPEIGSLADLATD
  262-  274 (23.60/12.58)	RQTIGTCIRVAPN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.32|      19|     126|    1423|    1441|       9
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 1423- 1441 (34.80/18.33)	STNHVSANTPGSTPQA.GVS
 1544- 1563 (29.52/14.22)	STRAATSPFPPSASSAeGVS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.11|      16|     253|     583|     600|      11
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  583-  600 (26.46/24.03)	DDvhMLDAPTLQ.DG......KATP
  866-  888 (20.65/10.26)	GD..MLDFAGLHiDEsslasfEPTP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP20061 with Med13 domain of Kingdom Fungi
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